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FCRL5 Fc receptor like 5 [ Homo sapiens (human) ]

Gene ID: 83416, updated on 11-Apr-2024

Summary

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Official Symbol
FCRL5provided by HGNC
Official Full Name
Fc receptor like 5provided by HGNC
Primary source
HGNC:HGNC:18508
See related
Ensembl:ENSG00000143297 MIM:605877; AllianceGenome:HGNC:18508
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820
Summary
This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]
Expression
Biased expression in lymph node (RPKM 14.3), spleen (RPKM 11.3) and 8 other tissues See more
Orthologs
all
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Genomic context

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See FCRL5 in Genome Data Viewer
Location:
1q23.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (157513377..157552515, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (156650413..156689576, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (157483167..157522305, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371456 Neighboring gene CRISPRi-validated cis-regulatory element chr1.9249 Neighboring gene SLAM family member 5 Neighboring gene long intergenic non-protein coding RNA 2772 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157279563-157280762 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1446 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1888 Neighboring gene NANOG hESC enhancer GRCh37_chr1:157391313-157391814 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1889 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1890 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:157489840-157491039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1891 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1892 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:157556896-157558095 Neighboring gene Fc receptor like 4 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:157593763-157594962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1447 Neighboring gene uncharacterized LOC105371457

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China. Liu HW, et al. Med Sci Monit, 2020 Sep 6. PMID 32892204, Free PMC Article
  2. Human Fc receptor-like 5 distinguishes IgG2 disulfide isoforms and deamidated charge variants. Alabi O, et al. Mol Immunol, 2017 Dec. PMID 29101848
  3. Fc Receptor-like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue-like Memory B Cells. Li H, et al. J Immunol, 2016 May 15. PMID 27076679
  4. B cell receptor induced Fc receptor-like 5 expression is mediated by multiple signaling pathways converging on NF-κB and NFAT. Damdinsuren B, et al. Mol Immunol, 2016 May. PMID 27065451
  5. FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure. Sullivan RT, et al. PLoS Pathog, 2015 May. PMID 25993340, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease.
    Title: SARS-CoV-2 spike-specific memory B cells express higher levels of T-bet and FcRL5 after non-severe COVID-19 as compared to severe disease.
  2. Fc receptor-like 4 and 5 define human atypical memory B cells.
    Title: Fc receptor-like 4 and 5 define human atypical memory B cells.
  3. The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China.
    Title: The rs6427384 and rs6692977 Single Nucleotide Polymorphisms of the Fc Receptor-Like 5 (FCRL5) Gene and the Risk of Ankylosing Spondylitis: A Case Control Study in a Single Center in China.
  4. FCRL5 has dual signaling capacity, while CD21 co-engagement serves as molecular switch, converting FCRL5 from a negative to a positive co-receptor; in tissues, B cells that co-express FCRL5 and CD21 could robustly respond to IgG immune complexes loaded with C3 fragments
    Title: CD21 and FCRL5 form a receptor complex with robust B-cell activating capacity.
  5. This study identified novel Single nucleotide polymorphism in FCRL3 and FCRL5 significantly associated with the risk for asthma with comorbid allergic rhinitis in the Chinese population
    Title: Genetic risk of FCRL3 and FCRL5 polymorphisms in children with asthma and allergic rhinitis in a Chinese Han population.
  6. based on FCRL5 binding, we can discern distinct changes in the IgG2 molecule, including the disulfide isoform structure and charge variants related to deamidation. Since both IgG2 deamidation and conversion of disulfide isoforms occur in vivo, these findings elucidate the biological FCRL5 ligand.
    Title: Human Fc receptor-like 5 distinguishes IgG2 disulfide isoforms and deamidated charge variants.
  7. we found that FCRL5 expression is induced specifically upon BCR stimulation and dissected the molecular mechanism
    Title: B cell receptor induced Fc receptor-like 5 expression is mediated by multiple signaling pathways converging on NF-κB and NFAT.
  8. this study revealed that the FCRL5+ tissue-like memory subset responds poorly to multiple stimuli compared with the FCRL5- subset, as reflected by reduced calcium mobilization and blunted cell proliferation
    Title: Fc Receptor-like 5 Expression Distinguishes Two Distinct Subsets of Human Circulating Tissue-like Memory B Cells.
  9. Data suggest that expression of FCRL5 (but not FCRL4) on surface of atypical (perhaps dysfunctional) memory B-Lymphocytes is up-regulated by exposure to Plasmodium falciparum antigens in subjects in Uganda where malaria is endemic.
    Title: FCRL5 Delineates Functionally Impaired Memory B Cells Associated with Plasmodium falciparum Exposure.
  10. FCRL5 is a new type of receptor that recognizes intact IgG, possibly enabling B cells to sense Ig quality. Recognition of undamaged IgG molecules by FCRL5 could allow B cells to engage recently produced Abs.
    Title: Human Fc receptor-like 5 binds intact IgG via mechanisms distinct from those of Fc receptors.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00333, FLJ00397, MGC119590, MGC119592, MGC119593, DKFZp667F216, DKFZp667E2019

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane signaling receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Fc receptor-like protein 5
Names
fc receptor homolog 5
fcR-like protein 5
immune receptor translocation-associated protein 2
immunoglobulin superfamily receptor translocation associated 2 (IRTA2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027723.1 RefSeqGene

    Range
    5006..44144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195388.2 → NP_001182317.1  Fc receptor-like protein 5 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the 3' coding region, resulting in frame-shift, as compared to variant 1. The resulting isoform (2) has a different and longer C-terminus, as compared to isoform 1.
    Source sequence(s)
    AF369794, AL353899, BC101067, BC101068
    UniProtKB/Swiss-Prot
    Q96RD9
    Conserved Domains (4) summary
    cd05752
    Location:23 → 100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:577 → 652
    IG_like; Immunoglobulin like
    pfam13895
    Location:105 → 185
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:565 → 638
    Ig_3; Immunoglobulin domain

  2. NM_031281.3 → NP_112571.2  Fc receptor-like protein 5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_112571.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the dominant isoform (1).
    Source sequence(s)
    AF369794, AL353899, BC101067, BE676280
    Consensus CDS
    CCDS1165.1
    UniProtKB/Swiss-Prot
    A0N0M2, B7WNT9, B7WP94, Q495Q2, Q495Q4, Q5VYK9, Q6UY46, Q96RD9
    Related
    ENSP00000354691.3, ENST00000361835.8
    Conserved Domains (4) summary
    cd05752
    Location:23 → 100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:577 → 652
    IG_like; Immunoglobulin like
    pfam13895
    Location:105 → 185
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:565 → 638
    Ig_3; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    157513377..157552515 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510030.3 → XP_011508332.1  Fc receptor-like protein 5 isoform X1

    Conserved Domains (3) summary
    smart00410
    Location:492 → 567
    IG_like; Immunoglobulin like
    pfam13895
    Location:20 → 100
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:480 → 553
    Ig_3; Immunoglobulin domain

  2. XM_011510032.3 → XP_011508334.1  Fc receptor-like protein 5 isoform X3

    Conserved Domains (4) summary
    cd05752
    Location:23 → 100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:484 → 559
    IG_like; Immunoglobulin like
    pfam13895
    Location:105 → 185
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:472 → 545
    Ig_3; Immunoglobulin domain

  3. XM_011510031.3 → XP_011508333.1  Fc receptor-like protein 5 isoform X2

    Conserved Domains (4) summary
    cd05752
    Location:23 → 100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:577 → 652
    IG_like; Immunoglobulin like
    pfam13895
    Location:105 → 185
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:565 → 638
    Ig_3; Immunoglobulin domain

  4. XM_011510033.3 → XP_011508335.1  Fc receptor-like protein 5 isoform X4

    Related
    ENSP00000357173.3, ENST00000368190.7
    Conserved Domains (4) summary
    cd05752
    Location:23 → 100
    Ig1_FcgammaR_like; Frst immunoglobulin (Ig)-like domain of Fcgamma-receptors (FcgammaRs) and similar proteins
    smart00410
    Location:577 → 652
    IG_like; Immunoglobulin like
    pfam13895
    Location:105 → 185
    Ig_2; Immunoglobulin domain
    pfam13927
    Location:565 → 638
    Ig_3; Immunoglobulin domain

  5. XM_047431422.1 → XP_047287378.1  Fc receptor-like protein 5 isoform X5

    Related
    ENSP00000357172.3, ENST00000368189.3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    156650413..156689576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338960.1 → XP_054194935.1  Fc receptor-like protein 5 isoform X1

  2. XM_054338962.1 → XP_054194937.1  Fc receptor-like protein 5 isoform X3

  3. XM_054338961.1 → XP_054194936.1  Fc receptor-like protein 5 isoform X2

  4. XM_054338963.1 → XP_054194938.1  Fc receptor-like protein 5 isoform X4

  5. XM_054338964.1 → XP_054194939.1  Fc receptor-like protein 5 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96RD9.3 GenPept UniProtKB/Swiss-Prot:Q96RD9

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