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CAMP cathelicidin antimicrobial peptide [ Homo sapiens (human) ]

Gene ID: 820, updated on 23-Mar-2024

Summary

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Official Symbol
CAMPprovided by HGNC
Official Full Name
cathelicidin antimicrobial peptideprovided by HGNC
Primary source
HGNC:HGNC:1472
See related
Ensembl:ENSG00000164047 MIM:600474; AllianceGenome:HGNC:1472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LL37; CAP18; CRAMP; HSD26; CAP-18; FALL39; FALL-39
Summary
This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. The protein plays an important role in innate immunity defense against viruses. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2021]
Annotation information
Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression
Restricted expression toward bone marrow (RPKM 591.5) See more
Orthologs
mouse all
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Genomic context

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See CAMP in Genome Data Viewer
Location:
3p21.31
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (48223495..48225485)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (48251295..48253285)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48264985..48266975)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene cell division cycle 25A Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:48228992-48229620 Neighboring gene NADH:ubiquinone oxidoreductase subunit B1 pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:48237715-48238244 Neighboring gene microRNA 4443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19823 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19824 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19825 Neighboring gene Sharpr-MPRA regulatory region 12857 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:48270677-48271176 Neighboring gene Sharpr-MPRA regulatory region 8193 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:48282361-48283278 Neighboring gene zinc finger protein 589 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:48297790-48298360 Neighboring gene mitochondrial ribosomal protein S18A pseudogene 1 Neighboring gene FCF1 pseudogene 2 Neighboring gene NME/NM23 nucleoside diphosphate kinase 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Impaired tolerance to the autoantigen LL-37 in acute coronary syndrome. Chernomordik F, et al. Front Immunol, 2023. PMID 37051254, Free PMC Article
  2. Cathelicidin LL-37 promotes EMT, migration and metastasis of hepatocellular carcinoma cells in vitro and mouse model. Zhang H, et al. Cell Adh Migr, 2023 Dec. PMID 36656313, Free PMC Article
  3. The Antimicrobial Peptide Cathelicidin Exerts Immunomodulatory Effects via Scavenger Receptors. Amagai R, et al. Int J Mol Sci, 2023 Jan 3. PMID 36614313, Free PMC Article
  4. Human cathelicidin LL-37 exerts amelioration effects against EHEC O157:H7 infection regarding inflammation, enteric dysbacteriosis, and impairment of gut barrier function. Fang X, et al. Peptides, 2023 Jan. PMID 36370932
  5. In silico assessment of missense point mutations on human cathelicidin LL-37. Porto WF, et al. J Mol Graph Model, 2023 Jan. PMID 36335830

See all (356) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cathelicidin Antimicrobial Peptide Levels in Atherosclerosis and Myocardial Infarction in Mice and Human.
    Title: Cathelicidin Antimicrobial Peptide Levels in Atherosclerosis and Myocardial Infarction in Mice and Human.
  2. Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis.
    Title: Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis.
  3. LL-37 improves sepsis-induced acute lung injury by suppressing pyroptosis in alveolar epithelial cells.
    Title: LL-37 improves sepsis-induced acute lung injury by suppressing pyroptosis in alveolar epithelial cells.
  4. Characterization of circulating extracellular traps and immune responses to citrullinated LL37 in psoriasis.
    Title: Characterization of circulating extracellular traps and immune responses to citrullinated LL37 in psoriasis.
  5. Cathelicidin Antimicrobial Peptide Acts as a Tumor Suppressor in Hepatocellular Carcinoma.
    Title: Cathelicidin Antimicrobial Peptide Acts as a Tumor Suppressor in Hepatocellular Carcinoma.
  6. Cathelicidin (LL-37) causes expression of inflammatory factors in coronary artery endothelial cells of Kawasaki disease by activating TLR4-NF-kappaB-NLRP3 signaling.
    Title: Cathelicidin (LL-37) causes expression of inflammatory factors in coronary artery endothelial cells of Kawasaki disease by activating TLR4-NF-κB-NLRP3 signaling.
  7. Epithelial-Immune Cell Crosstalk Determines the Activation of Immune Cells In Vitro by the Human Cathelicidin LL-37 at Low Physiological Concentrations.
    Title: Epithelial-Immune Cell Crosstalk Determines the Activation of Immune Cells In Vitro by the Human Cathelicidin LL-37 at Low Physiological Concentrations.
  8. The Antimicrobial Peptide LL-37 as a Predictor Biomarker for Periodontitis with the Presence and Absence of Smoking: A Case-Control Study.
    Title: The Antimicrobial Peptide LL-37 as a Predictor Biomarker for Periodontitis with the Presence and Absence of Smoking: A Case-Control Study.
  9. Insight into the Mechanism of Interactions between the LL-37 Peptide and Model Membranes of Legionella gormanii Bacteria.
    Title: Insight into the Mechanism of Interactions between the LL-37 Peptide and Model Membranes of Legionella gormanii Bacteria.
  10. Impaired tolerance to the autoantigen LL-37 in acute coronary syndrome.
    Title: Impaired tolerance to the autoantigen LL-37 in acute coronary syndrome.
Submit: New GeneRIF Correction See all GeneRIFs (320)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of cathelicidin antimicrobial peptide (CAMP) in peptide-treated PBMCs PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables lipopolysaccharide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in amyloid fibril formation EXP
Inferred from Experiment
more info
 PubMed 
involved_in amyloid fibril formation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antibacterial humoral response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to interleukin-1 IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to interleukin-6 IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to lipopolysaccharide IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to peptidoglycan IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to tumor necrosis factor IEA
Inferred from Electronic Annotation
more info
  
involved_in cytolysis EXP
Inferred from Experiment
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in defense response to Gram-positive bacterium IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response in mucosa IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within killing by host of symbiont cells IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in killing by host of symbiont cells IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in neutrophil activation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
located_in specific granule IDA
Inferred from Direct Assay
more info
 PubMed 
located_in specific granule lumen TAS
Traceable Author Statement
more info
  
located_in tertiary granule lumen TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
cathelicidin antimicrobial peptide
Names
18 kDa cationic antimicrobial protein
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_004345.5 → NP_004336.4  cathelicidin antimicrobial peptide preproprotein

    Status: VALIDATED

    Source sequence(s)
    X89658
    Consensus CDS
    CCDS2762.3
    UniProtKB/Swiss-Prot
    P49913, Q71SN9
    UniProtKB/TrEMBL
    A0A384NPR0, J3KNB4
    Related
    ENSP00000498425.1, ENST00000652295.2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    48223495..48225485
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    48251295..48253285
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P49913.1 GenPept UniProtKB/Swiss-Prot:P49913

Gene LinkOut

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