KIF18A kinesin family member 18A [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF18Aprovided by HGNC
Official Full Name: kinesin family member 18Aprovided by HGNC
Primary source: HGNC:HGNC:29441
See related: Ensembl:ENSG00000121621 MIM:611271; AllianceGenome:HGNC:29441
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PPP1R99; MS-KIF18A
Summary: KIF18A is a member of the kinesin superfamily of microtubule-associated molecular motors (see MIM 148760) that use hydrolysis of ATP to produce force and movement along microtubules (Luboshits and Benayahu, 2005 [PubMed 15878648]).[supplied by OMIM, Aug 2008]
Expression: Biased expression in testis (RPKM 7.1), bone marrow (RPKM 2.7) and 11 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p14.1

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (28020619..28108156, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (28161289..28248842, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (28042166..28129703, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Title: KIF18A inactivates hepatic stellate cells and alleviates liver fibrosis through the TTC3/Akt/mTOR pathway.
Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis.
Title: Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis.
Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
Title: Length-dependent poleward flux of sister kinetochore fibers promotes chromosome alignment.
Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
Title: Selective and ATP-competitive kinesin KIF18A inhibitor suppresses the replication of influenza A virus.
KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.
Title: KIF18A knockdown reduces proliferation, migration, invasion and enhances radiosensitivity of esophageal cancer.
Kinesin KIF18A is a novel PUM-regulated target promoting mitotic progression and survival of a human male germ cell line.
Title: Kinesin KIF18A is a novel PUM-regulated target promoting mitotic progression and survival of a human male germ cell line.
Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
Title: Chromosomally unstable tumor cells specifically require KIF18A for proliferation.
this study showed that KIF18A is overexpressed in patients with LUAD, further confirming that a high KIF18A expression level is correlated with higher pathologic tumor status stage, poorer tumor differentiation, lymph node metastasis, and tumor stage.
Title: High kinesin family member 18A expression correlates with poor prognosis in primary lung adenocarcinoma.
phylogenetic analysis revealed that the KIF18A gene family is remarkably conserved across vertebrates.
Title: Kinesin family member KIF18A is a critical cellular factor that regulates the differentiation and activation of dendritic cells.
The involvement of KIF18A in the progression and metastasis of lung adenocarcinoma.KIF18A is highly expressed in lung adenocarcinoma tissues.
Title: Kinesin Family Member 18A (KIF18A) Contributes to the Proliferation, Migration, and Invasion of Lung Adenocarcinoma Cells In Vitro and In Vivo.

Submit: New GeneRIF Correction See all GeneRIFs (38)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G02275 (e-PCR)
- UniSTS:10827

G63410 (e-PCR)
- UniSTS:140374

SHGC-145194 (e-PCR)
- UniSTS:174437

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables actin binding	IPI Inferred from Physical Interaction more info	PubMed
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule plus-end binding	IDA Inferred from Direct Assay more info	PubMed
enables plus-end-directed microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables plus-end-directed microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin-dependent ATPase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to estradiol stimulus	IEA Inferred from Electronic Annotation more info
involved_in male meiotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in microtubule depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in microtubule depolymerization	IDA Inferred from Direct Assay more info	PubMed
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic metaphase chromosome alignment	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic sister chromatid segregation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulation of microtubule cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in seminiferous tubule development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in caveola	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in microtubule cytoskeleton	IDA Inferred from Direct Assay more info
is_active_in mitotic spindle astral microtubule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitotic spindle midzone	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF18A

Names: protein phosphatase 1, regulatory subunit 99

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031217.4 → NP_112494.3 kinesin-like protein KIF18A

See identical proteins and their annotated locations for NP_112494.3

Status: VALIDATED

Source sequence(s)

AL136819, AW770226, DB080843

Consensus CDS

CCDS7867.1

UniProtKB/Swiss-Prot

Q4VPE3, Q86VS5, Q8NI77, Q9H0F3

UniProtKB/TrEMBL

B2R6H3

Related

ENSP00000263181.6, ENST00000263181.7

Conserved Domains (2) summary

cd01370
Location:11 → 355

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

pfam00225
Location:17 → 355

Kinesin; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

28020619..28108156 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017018379.2 → XP_016873868.1 kinesin-like protein KIF18A isoform X1

UniProtKB/Swiss-Prot

Q4VPE3, Q86VS5, Q8NI77, Q9H0F3

UniProtKB/TrEMBL

B2R6H3

Conserved Domains (2) summary

cd01370
Location:11 → 355

KISc_KIP3_like; Kinesin motor domain, KIP3-like subgroup

pfam00225
Location:17 → 355

Kinesin; Kinesin motor domain
XM_017018380.2 → XP_016873869.1 kinesin-like protein KIF18A isoform X2