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Zfpl1 zinc finger like protein 1 [ Mus musculus (house mouse) ]

Gene ID: 81909, updated on 3-Apr-2024

Summary

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Official Symbol
Zfpl1provided by MGI
Official Full Name
zinc finger like protein 1provided by MGI
Primary source
MGI:MGI:1891017
See related
Ensembl:ENSMUSG00000024792 AllianceGenome:MGI:1891017
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable metal ion binding activity. Predicted to act upstream of or within vesicle-mediated transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. Is expressed in several structures, including brain; early conceptus; genitourinary system; gut gland; and retina. Orthologous to human ZFPL1 (zinc finger protein like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum adult (RPKM 42.5), adrenal adult (RPKM 37.6) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
19 A; 19 4.34 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (6130792..6134961, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (6080757..6084975, complement)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45418 Neighboring gene zinc finger, HIT domain containing 2 Neighboring gene transmembrane 7 superfamily member 2 Neighboring gene VPS51 GARP complex subunit Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:6077181-6077364 Neighboring gene transmembrane protein 262 Neighboring gene STARR-positive B cell enhancer ABC_E3238 Neighboring gene STARR-positive B cell enhancer ABC_E4262 Neighboring gene cell division cycle associated 5 Neighboring gene predicted gene 550

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A putative human zinc-finger gene (ZFPL1) on 11q13, highly conserved in the mouse and expressed in exocrine pancreas. The European Consortium on MEN 1. Höppener JW, et al. Genomics, 1998 Jun 1. PMID 9653652
  2. ZFPL1, a novel ring finger protein required for cis-Golgi integrity and efficient ER-to-Golgi transport. Chiu CF, et al. EMBO J, 2008 Apr 9. PMID 18323775, Free PMC Article
  3. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Wang F, et al. Sci Adv, 2022 Jan 7. PMID 34995116, Free PMC Article
  4. Spatiotemporal gene expression patterns reveal molecular relatedness between retinal laminae. Jiang D, et al. J Comp Neurol, 2020 Apr 1. PMID 31609468, Free PMC Article
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • 1500015B20Rik

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001356994.2 → NP_001343923.1  zinc finger protein-like 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131692
    Consensus CDS
    CCDS29492.1
    UniProtKB/Swiss-Prot
    Q9DB43
    UniProtKB/TrEMBL
    A0A494B9Y9
    Related
    ENSMUSP00000125176.2, ENSMUST00000160977.8
    Conserved Domains (1) summary
    cd16487
    Location:50 → 104
    mRING-H2-C3DHC3_ZFPL1; Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) and similar proteins

  2. NM_001424811.1 → NP_001411740.1  zinc finger protein-like 1

    Status: VALIDATED

    Source sequence(s)
    AC131692
    UniProtKB/Swiss-Prot
    Q9DB43

  3. NM_001424812.1 → NP_001411741.1  zinc finger protein-like 1

    Status: VALIDATED

    Source sequence(s)
    AC131692
    UniProtKB/Swiss-Prot
    Q9DB43

  4. NM_024231.4 → NP_077193.1  zinc finger protein-like 1

    See identical proteins and their annotated locations for NP_077193.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the shorter transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC131692
    Consensus CDS
    CCDS29492.1
    UniProtKB/Swiss-Prot
    Q9DB43
    UniProtKB/TrEMBL
    A0A494B9Y9
    Related
    ENSMUSP00000025707.3, ENSMUST00000025707.9
    Conserved Domains (1) summary
    cd16487
    Location:50 → 104
    mRING-H2-C3DHC3_ZFPL1; Modified RING finger, H2 subclass (C3DHC3-type), found in zinc finger protein-like 1 (ZFPL1) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    6130792..6134961 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB43.1 GenPept UniProtKB/Swiss-Prot:Q9DB43

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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