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C1qtnf3 C1q and tumor necrosis factor related protein 3 [ Mus musculus (house mouse) ]

Gene ID: 81799, updated on 5-Mar-2024

Summary

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Official Symbol
C1qtnf3provided by MGI
Official Full Name
C1q and tumor necrosis factor related protein 3provided by MGI
Primary source
MGI:MGI:1932136
See related
Ensembl:ENSMUSG00000058914 AllianceGenome:MGI:1932136
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adim; Cors; CTRP3; Corcs; CORS26; CORS-26; 2310005P21Rik
Summary
Enables identical protein binding activity. Involved in positive regulation of adiponectin secretion and positive regulation of cytokine production. Acts upstream of or within glucose homeostasis; negative regulation of gluconeogenesis; and positive regulation of intracellular signal transduction. Located in extracellular space. Part of protein-containing complex. Is expressed in several structures, including central nervous system; epithelium; jaw; metanephros; and musculoskeletal system. Orthologous to human C1QTNF3 (C1q and TNF related 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 35.7), subcutaneous fat pad adult (RPKM 12.5) and 5 other tissues See more
Orthologs
human all
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Genomic context

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Location:
15 A1; 15 5.38 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 15 NC_000081.7 (10952418..10980248)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 15 NC_000081.6 (10952119..10980162)

Chromosome 15 - NC_000081.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19276 Neighboring gene predicted gene, 29742 Neighboring gene predicted gene, 34315 Neighboring gene STARR-seq mESC enhancer starr_37987 Neighboring gene predicted gene, 52174 Neighboring gene alpha-methylacyl-CoA racemase Neighboring gene solute carrier family 45, member 2 Neighboring gene STARR-seq mESC enhancer starr_37988

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Adipocyte-Derived CTRP3 Exhibits Anti-Inflammatory Effects via LAMP1-STAT3 Axis in Psoriasis. Xue K, et al. J Invest Dermatol, 2022 May. PMID 34687744
  2. C1q/tumor necrosis factor-related protein-3 acts as a target treating hepatic fibrosis. Sun BR, et al. Eur Rev Med Pharmacol Sci, 2021 Sep. PMID 34533812
  3. Anti-Inflammatory Effects of C1q/Tumor Necrosis Factor-Related Protein 3 (CTRP3) in Endothelial Cells. Schmid A, et al. Cells, 2021 Aug 20. PMID 34440913, Free PMC Article
  4. Deficiency of C1q/TNF-related protein 3 (CTRP3) decreases adipose tissue weight in diet-induced obesity mice. Maeda T, et al. Mol Biol Rep, 2020 Nov. PMID 33057992
  5. CTRP3 ameliorates cerulein-induced severe acute pancreatitis in mice via SIRT1/NF-κB/p53 axis. Lv C, et al. Biosci Rep, 2020 Oct 30. PMID 32219332, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CTRP3 regulates NF-kappaB and TGFbeta1/Smad3 pathways to alleviate airway inflammation and remodeling in asthmatic mice induced by OVA.
    Title: CTRP3 regulates NF-κB and TGFβ1/Smad3 pathways to alleviate airway inflammation and remodeling in asthmatic mice induced by OVA.
  2. CTRP3 promotes TNF-alpha-induced apoptosis and barrier dysfunction in salivary epithelial cells.
    Title: CTRP3 promotes TNF-α-induced apoptosis and barrier dysfunction in salivary epithelial cells.
  3. CTRP3 alleviates myocardial ischemia/reperfusion injury in mice through activating LAMP1/JIP2/JNK pathway.
    Title: CTRP3 alleviates myocardial ischemia/reperfusion injury in mice through activating LAMP1/JIP2/JNK pathway.
  4. Adipocyte-Derived CTRP3 Exhibits Anti-Inflammatory Effects via LAMP1-STAT3 Axis in Psoriasis.
    Title: Adipocyte-Derived CTRP3 Exhibits Anti-Inflammatory Effects via LAMP1-STAT3 Axis in Psoriasis.
  5. CTRP-3 Regulates NOD1-mediated Inflammation and NOD1 Expression in Adipocytes and Adipose Tissue.
    Title: CTRP-3 Regulates NOD1-mediated Inflammation and NOD1 Expression in Adipocytes and Adipose Tissue.
  6. C1q/tumor necrosis factor-related protein-3 acts as a target treating hepatic fibrosis.
    Title: C1q/tumor necrosis factor-related protein-3 acts as a target treating hepatic fibrosis.
  7. The adipokine C1q/TNF-related protein-3 (CTRP-3) inhibits Toll-like receptor (TLR)-induced expression of Cathelicidin antimicrobial peptide (CAMP) in adipocytes.
    Title: The adipokine C1q/TNF-related protein-3 (CTRP-3) inhibits Toll-like receptor (TLR)-induced expression of Cathelicidin antimicrobial peptide (CAMP) in adipocytes.
  8. Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice.
    Title: Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice.
  9. The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation.
    Title: The CTRP3-AdipoR2 Axis Regulates the Development of Experimental Autoimmune Encephalomyelitis by Suppressing Th17 Cell Differentiation.
  10. Anti-Inflammatory Effects of C1q/Tumor Necrosis Factor-Related Protein 3 (CTRP3) in Endothelial Cells.
    Title: Anti-Inflammatory Effects of C1q/Tumor Necrosis Factor-Related Protein 3 (CTRP3) in Endothelial Cells.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (5)  1 citation
  • Endonuclease-mediated (4) 

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within glucose homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in intracellular triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of gluconeogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of gluconeogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of monocyte chemotactic protein-1 production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of adiponectin secretion IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of adiponectin secretion ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of cytokine production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
complement C1q tumor necrosis factor-related protein 3
Names
adiponectin m
cartducin
cartonectin
collagenous repeat-containing sequence 26 kDa protein
secretory protein CORS26
NP_001191063.1
NP_112150.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001204134.1 → NP_001191063.1  complement C1q tumor necrosis factor-related protein 3 isoform 1 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102219
    Consensus CDS
    CCDS56977.1
    UniProtKB/TrEMBL
    D3YZ61
    Related
    ENSMUSP00000106152.2, ENSMUST00000110523.2
    Conserved Domains (2) summary
    pfam00386
    Location:192 → 315
    C1q; C1q domain
    pfam01391
    Location:147 → 186
    Collagen; Collagen triple helix repeat (20 copies)

  2. NM_030888.4 → NP_112150.1  complement C1q tumor necrosis factor-related protein 3 isoform 2 precursor

    See identical proteins and their annotated locations for NP_112150.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AC102219, AK029352
    Consensus CDS
    CCDS27380.1
    UniProtKB/Swiss-Prot
    Q9ES30
    UniProtKB/TrEMBL
    Q4ZJN6
    Related
    ENSMUSP00000022853.9, ENSMUST00000022853.15
    Conserved Domains (2) summary
    pfam01391
    Location:71 → 113
    Collagen; Collagen triple helix repeat (20 copies)
    pfam00386
    Location:119 → 242
    C1q; C1q domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000081.7 Reference GRCm39 C57BL/6J

    Range
    10952418..10980248
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ES30.1 GenPept UniProtKB/Swiss-Prot:Q9ES30

Gene LinkOut

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