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SLCO5A1 solute carrier organic anion transporter family member 5A1 [ Homo sapiens (human) ]

Gene ID: 81796, updated on 5-Mar-2024

Summary

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Official Symbol
SLCO5A1provided by HGNC
Official Full Name
solute carrier organic anion transporter family member 5A1provided by HGNC
Primary source
HGNC:HGNC:19046
See related
Ensembl:ENSG00000137571 MIM:613543; AllianceGenome:HGNC:19046
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OATPJ; OATP-J; OATP5A1; OATPRP4; OATP-RP4; SLC21A15
Summary
Predicted to enable sodium-independent organic anion transmembrane transporter activity. Predicted to be involved in sodium-independent organic anion transport. Located in intracellular membrane-bounded organelle and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in small intestine (RPKM 68.6), ovary (RPKM 66.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8q13.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (69667046..69834978, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (70096700..70264566, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (70579281..70747213, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1603 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:70378771-70379311 Neighboring gene sulfatase 1 Neighboring gene NANOG hESC enhancer GRCh37_chr8:70451186-70451687 Neighboring gene MPRA-validated peak7064 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:70556317-70556868 Neighboring gene Sharpr-MPRA regulatory region 11728/13723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:70623385-70623885 Neighboring gene uncharacterized LOC105375889 Neighboring gene RN7SK pseudogene 29 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19263 Neighboring gene Sharpr-MPRA regulatory region 147 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27500 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27501 Neighboring gene TMX1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19265 Neighboring gene SLCO5A1 antisense RNA 1 Neighboring gene BAG cochaperone 4 pseudogene Neighboring gene RNA, 7SL, cytoplasmic 675, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of SLCO5A1/OATP5A1, a solute carrier transport protein with non-classical function. Sebastian K, et al. PLoS One, 2013. PMID 24376674, Free PMC Article
  2. Differential Associations of SLCO Transporters with Prostate Cancer Aggressiveness between African Americans and European Americans. Tang L, et al. Cancer Epidemiol Biomarkers Prev, 2021 May. PMID 33619025, Free PMC Article
  3. Mesomelia-synostoses syndrome results from deletion of SULF1 and SLCO5A1 genes at 8q13. Isidor B, et al. Am J Hum Genet, 2010 Jul 9. PMID 20602915, Free PMC Article
  4. The superfamily of organic anion transporting polypeptides. Hagenbuch B, et al. Biochim Biophys Acta, 2003 Jan 10. PMID 12507753
  5. Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy. Brenner S, et al. Cancer Lett, 2015 Jan 28. PMID 25301452

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Differential Associations of SLCO Transporters with Prostate Cancer Aggressiveness between African Americans and European Americans.
    Title: Differential Associations of SLCO Transporters with Prostate Cancer Aggressiveness between African Americans and European Americans.
  2. High OATP5A1 expression is associated with small cell lung cancer.
    Title: Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy.
  3. SLCO5A1 is an organic anion transporting polypeptide which is involved in biological processes that require the reorganization of the cell shape, such as differentiation and migration.
    Title: Characterization of SLCO5A1/OATP5A1, a solute carrier transport protein with non-classical function.
  4. tissue-specific localization of OATP2B1, OATP3A1 and OATP5A1 has been analyzed in normal mammary tissue and corresponding breast cancer tissues.
    Title: Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue.
  5. Haploinsufficiency of SULF1 combined with haploinsufficiency of SLCO5A1 (or the altered expression of a neighboring gene through position effect) could be necessary in the pathogenesis of MSS.
    Title: Mesomelia-synostoses syndrome results from deletion of SULF1 and SLCO5A1 genes at 8q13.
  6. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Common genetic variation and the control of HIV-1 in humans.
EBI GWAS Catalog
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ39560

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables sodium-independent organic anion transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in sodium-independent organic anion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in basolateral plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
solute carrier organic anion transporter family member 5A1
Names
organic anion transporter polypeptide-related protein 4
solute carrier family 21 (organic anion transporter), member 15
solute carrier family 21 member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001146008.2 → NP_001139480.1  solute carrier organic anion transporter family member 5A1 isoform 2

    See identical proteins and their annotated locations for NP_001139480.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an exon in the coding region, which results in a frameshift and an early stop codon compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC079089, AC091047, AF205075, AK022760, CA449383
    Consensus CDS
    CCDS55243.1
    UniProtKB/Swiss-Prot
    Q9H2Y9
    Related
    ENSP00000434422.1, ENST00000524945.5
    Conserved Domains (3) summary
    cd06174
    Location:131 → 531
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:551 → 605
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:129 → 674
    OATP; Organic Anion Transporter Polypeptide (OATP) family

  2. NM_001146009.1 → NP_001139481.1  solute carrier organic anion transporter family member 5A1 isoform 3

    See identical proteins and their annotated locations for NP_001139481.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The encoded protein (isoform 3) is shorter than isoform 1.
    Source sequence(s)
    AC079089, AC091047, AF205075, BC139755, CA449383
    Consensus CDS
    CCDS55242.1
    UniProtKB/Swiss-Prot
    Q9H2Y9
    Related
    ENSP00000431611.1, ENST00000530307.1
    Conserved Domains (1) summary
    cd17404
    Location:128 → 620
    MFS_SLCO5_OATP5; Solute carrier organic anion transporter 5 family of the Major Facilitator Superfamily of transporters

  3. NM_030958.3 → NP_112220.2  solute carrier organic anion transporter family member 5A1 isoform 1

    See identical proteins and their annotated locations for NP_112220.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC091047, AK096879, BC137424, CA449383
    Consensus CDS
    CCDS6205.1
    UniProtKB/Swiss-Prot
    A4QPC2, B2RPF7, B3KMU7, E9PKK5, G3V1C0, Q9H2Y9
    Related
    ENSP00000260126.3, ENST00000260126.9
    Conserved Domains (3) summary
    cd06174
    Location:131 → 531
    MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
    cd01330
    Location:551 → 605
    KAZAL_SLC21; The kazal-type serine protease inhibitor domain has been detected in an extracellular loop region of solute carrier 21 (SLC21) family members (organic anion transporters) , which may regulate the specificity of anion uptake. The KAZAL_SLC21 domain is a ...
    pfam03137
    Location:129 → 734
    OATP; Organic Anion Transporter Polypeptide (OATP) family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    69667046..69834978 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    70096700..70264566 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H2Y9.2 GenPept UniProtKB/Swiss-Prot:Q9H2Y9

Gene LinkOut

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