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Pde1c phosphodiesterase 1C [ Rattus norvegicus (Norway rat) ]

Gene ID: 81742, updated on 11-Apr-2024

Summary

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Official Symbol
Pde1cprovided by RGD
Official Full Name
phosphodiesterase 1Cprovided by RGD
Primary source
RGD:68332
See related
Ensembl:ENSRNOG00000012337 AllianceGenome:RGD:68332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables cAMP binding activity; calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-dependent cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus and sensory perception of smell. Acts upstream of or within response to calcium ion. Located in neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 43.5), Kidney (RPKM 40.2) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
4q24
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (86629074..87108147, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (85300858..85777948, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (86359762..86925044, complement)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1, regulatory subunit 17 Neighboring gene uncharacterized LOC134486774 Neighboring gene apolipoprotein O, pseudogene 4 Neighboring gene transfer RNA serine (anticodon AGA) 44 Neighboring gene transfer RNA threonine (anticodon AGU) 9 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene small nucleolar RNA SNORA17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C. Sun W, et al. Acta Biochim Biophys Sin (Shanghai), 2022 Mar 25. PMID 35538034, Free PMC Article
  2. Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells. Cai Y, et al. Arterioscler Thromb Vasc Biol, 2011 Mar. PMID 21148428, Free PMC Article
  3. Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia. Cai Y, et al. Circ Res, 2015 Mar 27. PMID 25608528, Free PMC Article
  4. Gene expression and protein localization of calmodulin-dependent phosphodiesterase in adult rat retina. Santone R, et al. J Neurosci Res, 2006 Oct. PMID 16881052
  5. Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons. Cygnar KD, et al. Nat Neurosci, 2009 Apr. PMID 19305400, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C.
    Title: Endoplasmic reticulum stress mediates homocysteine-induced hypertrophy of cardiac cells through activation of cyclic nucleotide phosphodiesterase 1C.
  2. In cultured rat aortic SMCs, PDE1C deficiency or PDE1 inhibition attenuated SMC proliferation and migration. PDE1C plays a critical role in regulating the stability of growth factor receptors, endocytosis and lysosome-dependent degradation.
    Title: Role of cAMP-phosphodiesterase 1C signaling in regulating growth factor receptor stability, vascular smooth muscle cell growth, migration, and neointimal hyperplasia.
  3. Suggest that PDE1C plays a critical role in regulating collagen homeostasis during pathological vascular remodeling.
    Title: Cyclic nucleotide phosphodiesterase 1 regulates lysosome-dependent type I collagen protein degradation in vascular smooth muscle cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables cAMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to calcium ion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within sensory perception of smell ISO
Inferred from Sequence Orthology
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cilium ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in neuronal cell body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
Names
3',5'-cyclic-AMP phosphodiesterase
3',5'-cyclic-GMP phosphodiesterase
calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
cam-PDE 1C
cyclic nucleotide phosphodiesterase 1 C
dual specificity Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C
phosphodiesterase 1C calmodulin-dependent (70kD)
NP_112340.1
XP_008761144.2
XP_038964360.1
XP_038964361.1
XP_038964362.1
XP_038964363.1
XP_063142821.1
XP_063142822.1
XP_063142823.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031078.2 → NP_112340.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C

    See identical proteins and their annotated locations for NP_112340.1

    Status: PROVISIONAL

    Source sequence(s)
    L41045
    UniProtKB/Swiss-Prot
    Q63421
    UniProtKB/TrEMBL
    A0A8I6AQQ1, A6K104
    Related
    ENSRNOP00000096395.1, ENSRNOT00000098186.1
    Conserved Domains (2) summary
    pfam00233
    Location:287 → 515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146 → 202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    86629074..87108147 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762922.4 → XP_008761144.2  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y1F5, A6K105, F1LMX4
    Conserved Domains (3) summary
    PTZ00121
    Location:543 → 635
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:227 → 455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86 → 142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  2. XM_039108434.2 → XP_038964362.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X2

    UniProtKB/TrEMBL
    A0A8I5Y1F5, A6K105, F1LMX4
    Related
    ENSRNOP00000017531.8
    Conserved Domains (3) summary
    PTZ00121
    Location:543 → 635
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:227 → 455
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:86 → 142
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  3. XM_039108433.2 → XP_038964361.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQQ1, A6K104
    Related
    ENSRNOP00000084095.1
    Conserved Domains (3) summary
    PTZ00121
    Location:603 → 695
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:287 → 515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146 → 202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  4. XM_039108432.2 → XP_038964360.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X1

    UniProtKB/TrEMBL
    A0A8I6AQQ1, A6K104
    Conserved Domains (3) summary
    PTZ00121
    Location:603 → 695
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:287 → 515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146 → 202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  5. XM_063286751.1 → XP_063142821.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X4

    UniProtKB/TrEMBL
    A0A8I6AMU0, A6K107

  6. XM_039108435.2 → XP_038964363.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X3

    UniProtKB/TrEMBL
    A0A8I6A8V6, A0A8I6AQQ1, A6K104
    Related
    ENSRNOP00000089783.1
    Conserved Domains (3) summary
    PTZ00121
    Location:603 → 690
    PTZ00121; MAEBL; Provisional
    pfam00233
    Location:287 → 515
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08499
    Location:146 → 202
    PDEase_I_N; 3'5'-cyclic nucleotide phosphodiesterase N-terminal

  7. XM_063286753.1 → XP_063142823.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

    UniProtKB/TrEMBL
    A6K108

  8. XM_063286752.1 → XP_063142822.1  dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C isoform X5

    UniProtKB/TrEMBL
    A6K108
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q63421.1 GenPept UniProtKB/Swiss-Prot:Q63421

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