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Pcm1 pericentriolar material 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 81740, updated on 13-Apr-2024

Summary

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Official Symbol
Pcm1provided by RGD
Official Full Name
pericentriolar material 1provided by RGD
Primary source
RGD:620901
See related
Ensembl:ENSRNOG00000010155 AllianceGenome:RGD:620901
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Involved in protein localization to centrosome. Predicted to be located in several cellular components, including ciliary transition zone; nuclear membrane; and pericentriolar material. Predicted to be part of protein-containing complex. Predicted to be active in centriolar satellite; centriole; and ciliary basal body. Predicted to colocalize with centrosome. Orthologous to human PCM1 (pericentriolar material 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 287.9), Testes (RPKM 285.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
16q12.1
Exon count:
44
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 16 NC_086034.1 (57711833..57808842, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 16 NC_051351.1 (51008315..51105261, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 16 NC_005115.4 (54040721..54137675, complement)

Chromosome 16 - NC_086034.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102547443 Neighboring gene FSHD region gene 1 Neighboring gene N-acylsphingosine amidohydrolase 1 Neighboring gene fibrinogen-like 1 Neighboring gene microtubule associated scaffold protein 1 Neighboring gene uncharacterized LOC103693968

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Neuroanatomical and behavioral deficits in mice haploinsufficient for Pericentriolar material 1 (Pcm1). Zoubovsky S, et al. Neurosci Res, 2015 Sep. PMID 25697395, Free PMC Article
  2. Arrest of cell cycle progression during first interphase in murine zygotes microinjected with anti-PCM-1 antibodies. Balczon R, et al. Cell Motil Cytoskeleton, 2002 Jul. PMID 12112146
  3. Non-membranous granular organelle consisting of PCM-1: subcellular distribution and cell-cycle-dependent assembly/disassembly. Kubo A, et al. J Cell Sci, 2003 Mar 1. PMID 12571289
  4. Centriolar satellites: molecular characterization, ATP-dependent movement toward centrioles and possible involvement in ciliogenesis. Kubo A, et al. J Cell Biol, 1999 Nov 29. PMID 10579718, Free PMC Article
  5. A CaMKIIβ signaling pathway at the centrosome regulates dendrite patterning in the brain. Puram SV, et al. Nat Neurosci, 2011 Jul 3. PMID 21725312, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in centrosome cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in centrosome cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic microtubule organization ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within interkinetic nuclear migration ISO
Inferred from Sequence Orthology
more info
  
involved_in intraciliary transport involved in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intraciliary transport involved in cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule anchoring ISO
Inferred from Sequence Orthology
more info
  
involved_in microtubule anchoring at centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within microtubule anchoring at centrosome ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neurogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuron migration ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuronal stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
involved_in non-motile cilium assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of intracellular protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization to centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to centrosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein localization to centrosome ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within protein localization to organelle ISO
Inferred from Sequence Orthology
more info
  
involved_in protein-containing complex localization to centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of protein complex stability ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within social behavior ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriolar satellite IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
located_in centriolar satellite ISO
Inferred from Sequence Orthology
more info
  
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole ISO
Inferred from Sequence Orthology
more info
  
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in ciliary basal body ISO
Inferred from Sequence Orthology
more info
  
located_in ciliary transition zone ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
NOT located_in non-motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in pericentriolar material ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pericentriolar material 1 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031076.1 → NP_112338.1  pericentriolar material 1 protein

    See identical proteins and their annotated locations for NP_112338.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000016
    UniProtKB/TrEMBL
    A0A8I5ZUW5, A6JPT8, G3V7E6
    Related
    ENSRNOP00000014202.4, ENSRNOT00000014202.7
    Conserved Domains (1) summary
    pfam15717
    Location:1369 → 2000
    PCM1_C; Pericentriolar material 1 C-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086034.1 Reference GRCr8

    Range
    57711833..57808842 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008771284.4 → XP_008769506.1  pericentriolar material 1 protein isoform X1

    See identical proteins and their annotated locations for XP_008769506.1

    UniProtKB/TrEMBL
    A0A8I5ZUW5
    Conserved Domains (2) summary
    pfam15717
    Location:1471 → 2102
    PCM1_C; Pericentriolar material 1 C terminus
    cl00439
    Location:845 → 929
    UPF0047; uncharacterized protein family UPF0047

  2. XM_006253188.5 → XP_006253250.1  pericentriolar material 1 protein isoform X6

    See identical proteins and their annotated locations for XP_006253250.1

    UniProtKB/TrEMBL
    A0A8I5ZUW5, A0A8I6A6S1, A6JPT9
    Related
    ENSRNOP00000089217.1
    Conserved Domains (2) summary
    pfam15717
    Location:1408 → 2039
    PCM1_C; Pericentriolar material 1 C terminus
    cl00439
    Location:782 → 866
    UPF0047; uncharacterized protein family UPF0047

  3. XM_006253183.5 → XP_006253245.1  pericentriolar material 1 protein isoform X1

    See identical proteins and their annotated locations for XP_006253245.1

    UniProtKB/TrEMBL
    A0A8I5ZUW5
    Conserved Domains (2) summary
    pfam15717
    Location:1471 → 2102
    PCM1_C; Pericentriolar material 1 C terminus
    cl00439
    Location:845 → 929
    UPF0047; uncharacterized protein family UPF0047

  4. XM_063275772.1 → XP_063131842.1  pericentriolar material 1 protein isoform X13

    UniProtKB/TrEMBL
    A0A8I5Y9X1

  5. XM_063275770.1 → XP_063131840.1  pericentriolar material 1 protein isoform X11

  6. XM_017600257.3 → XP_017455746.1  pericentriolar material 1 protein isoform X10

    UniProtKB/TrEMBL
    A0A8I5ZUW5
    Related
    ENSRNOP00000078093.1

  7. XM_039094854.2 → XP_038950782.1  pericentriolar material 1 protein isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZUW5
    Conserved Domains (1) summary
    pfam15717
    Location:1432 → 2063
    PCM1_C; Pericentriolar material 1 C-terminus

  8. XM_063275771.1 → XP_063131841.1  pericentriolar material 1 protein isoform X12

  9. XM_063275769.1 → XP_063131839.1  pericentriolar material 1 protein isoform X9

  10. XM_039094856.2 → XP_038950784.1  pericentriolar material 1 protein isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZUW5
    Conserved Domains (1) summary
    pfam15717
    Location:1353 → 1984
    PCM1_C; Pericentriolar material 1 C-terminus

  11. XM_006253187.5 → XP_006253249.1  pericentriolar material 1 protein isoform X5

    UniProtKB/TrEMBL
    A0A8I5ZUW5
    Conserved Domains (2) summary
    pfam15717
    Location:1413 → 2044
    PCM1_C; Pericentriolar material 1 C terminus
    cl00439
    Location:787 → 871
    UPF0047; uncharacterized protein family UPF0047

  12. XM_006253186.5 → XP_006253248.1  pericentriolar material 1 protein isoform X4

    UniProtKB/TrEMBL
    A0A0G2K0X1, A0A8I5ZUW5
    Related
    ENSRNOP00000071613.2
    Conserved Domains (3) summary
    pfam02463
    Location:226 → 987
    SMC_N; RecF/RecN/SMC N terminal domain
    pfam15717
    Location:1416 → 2047
    PCM1_C; Pericentriolar material 1 C terminus
    cl00439
    Location:845 → 929
    UPF0047; uncharacterized protein family UPF0047

  13. XM_006253185.5 → XP_006253247.1  pericentriolar material 1 protein isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZUW5
    Conserved Domains (2) summary
    pfam15717
    Location:1471 → 2049
    PCM1_C; Pericentriolar material 1 C terminus
    cl00439
    Location:845 → 929
    UPF0047; uncharacterized protein family UPF0047

  14. XM_006253184.5 → XP_006253246.1  pericentriolar material 1 protein isoform X1

    See identical proteins and their annotated locations for XP_006253246.1

    UniProtKB/TrEMBL
    A0A8I5ZUW5
    Related
    ENSRNOP00000082952.1
    Conserved Domains (2) summary
    pfam15717
    Location:1471 → 2102
    PCM1_C; Pericentriolar material 1 C terminus
    cl00439
    Location:845 → 929
    UPF0047; uncharacterized protein family UPF0047

  15. XM_063275766.1 → XP_063131836.1  pericentriolar material 1 protein isoform X7

    UniProtKB/TrEMBL
    A6JPT8, G3V7E6

  16. XM_063275765.1 → XP_063131835.1  pericentriolar material 1 protein isoform X6

    UniProtKB/TrEMBL
    A0A8I6A6S1, A6JPT9

  17. XM_063275768.1 → XP_063131838.1  pericentriolar material 1 protein isoform X7

    UniProtKB/TrEMBL
    A6JPT8, G3V7E6

  18. XM_063275762.1 → XP_063131832.1  pericentriolar material 1 protein isoform X1

  19. XM_008771285.4 → XP_008769507.1  pericentriolar material 1 protein isoform X1

    See identical proteins and their annotated locations for XP_008769507.1

    UniProtKB/TrEMBL
    A0A8I5ZUW5
    Conserved Domains (2) summary
    pfam15717
    Location:1471 → 2102
    PCM1_C; Pericentriolar material 1 C terminus
    cl00439
    Location:845 → 929
    UPF0047; uncharacterized protein family UPF0047

  20. XM_063275767.1 → XP_063131837.1  pericentriolar material 1 protein isoform X7

    UniProtKB/TrEMBL
    A6JPT8, G3V7E6

  21. XM_063275764.1 → XP_063131834.1  pericentriolar material 1 protein isoform X1

  22. XM_063275763.1 → XP_063131833.1  pericentriolar material 1 protein isoform X1

  23. XM_063275773.1 → XP_063131843.1  pericentriolar material 1 protein isoform X14

Nucleotide Protein Strain
Heading Accession and Version

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