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Ankrd17 ankyrin repeat domain 17 [ Mus musculus (house mouse) ]

Gene ID: 81702, updated on 3-Apr-2024

Summary

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Official Symbol
Ankrd17provided by MGI
Official Full Name
ankyrin repeat domain 17provided by MGI
Primary source
MGI:MGI:1932101
See related
Ensembl:ENSMUSG00000055204 AllianceGenome:MGI:1932101
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Foe; Gtar; Mask; mKIAA0697; A930008M01; 4933425K22Rik; A130069E23Rik
Summary
This gene encodes a protein with ankyrin repeats, which are associated with protein-protein interactions. Studies suggest that this protein is involved in liver development. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in placenta adult (RPKM 15.9), whole brain E14.5 (RPKM 11.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 E1; 5 44.32 cM
Exon count:
37
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (90375025..90517133, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (90227166..90368693, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 35936 Neighboring gene STARR-seq mESC enhancer starr_13591 Neighboring gene STARR-positive B cell enhancer ABC_E4763 Neighboring gene cytochrome c oxidase assembly protein 18 Neighboring gene STARR-seq mESC enhancer starr_13593 Neighboring gene STARR-seq mESC enhancer starr_13595 Neighboring gene STARR-positive B cell enhancer ABC_E10327 Neighboring gene STARR-seq mESC enhancer starr_13598 Neighboring gene predicted gene 9958 Neighboring gene predicted gene, 35999 Neighboring gene albumin (Alb) 5' regulatory region Neighboring gene albumin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Tight regulation of a timed nuclear import wave of EKLF by PKCθ and FOE during Pro-E to Baso-E transition. Shyu YC, et al. Dev Cell, 2014 Feb 24. PMID 24576425
  2. A gene trap integration provides an early in situ marker for hepatic specification of the foregut endoderm. Watt AJ, et al. Mech Dev, 2001 Feb. PMID 11165478
  3. Mask family proteins ANKHD1 and ANKRD17 regulate YAP nuclear import and stability. Sidor C, et al. Elife, 2019 Oct 29. PMID 31661072, Free PMC Article
  4. Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice. Ray D, et al. Biol Reprod, 2012 Apr. PMID 22190705, Free PMC Article
  5. An induction gene trap screen in embryonic stem cells: Identification of genes that respond to retinoic acid in vitro. Forrester LM, et al. Proc Natl Acad Sci U S A, 1996 Feb 20. PMID 8643689, Free PMC Article

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ANKRD17 expression was predominantly restricted to pachytene spermatocytes and round spermatids. ANKRD17 was diffusely distributed throughout the nucleus of pachytene cells but excluded from the XY body and other heterochromatic regions.
    Title: Experimental validation of Ankrd17 and Anapc10, two novel meiotic genes predicted by computational models in mice.
  2. Data demonstrate the indispensability of Ankrd17 functioning for vascular maturation during early development.
    Title: Ankrd17, an ubiquitously expressed ankyrin factor, is essential for the vascular integrity during embryogenesis.
  3. Ankrd17 is an important downstream effector of cyclin E/Cdk2 and positively regulates G(1)/S transition
    Title: Identification and functional analysis of a novel cyclin e/cdk2 substrate ankrd17.
  4. there are overlapping reading frames in the mouse and human genes for 4E-BP3 and MASK
    Title: Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within blood vessel maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to bacterium ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within endoderm development TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of smooth muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of MDA-5 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of RIG-I signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA replication ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of chromatin ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 17
Names
ankyrin repeat domain containing protein FOE
gene trap ankyrin repeat protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001401341.1 → NP_001388270.1  ankyrin repeat domain-containing protein 17 isoform c

    Status: REVIEWED

    Source sequence(s)
    AC117578, AC162171

  2. NM_030886.2 → NP_112148.2  ankyrin repeat domain-containing protein 17 isoform a

    See identical proteins and their annotated locations for NP_112148.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AC140220, AC162171
    Consensus CDS
    CCDS57354.1
    UniProtKB/Swiss-Prot
    Q3TV99, Q5F4T7, Q6PG69, Q6ZQ66, Q8CHT4, Q99NH0
    UniProtKB/TrEMBL
    E9Q804
    Related
    ENSMUSP00000014421.9, ENSMUST00000014421.15
    Conserved Domains (9) summary
    TIGR02926
    Location:801 → 877
    AhaH; ATP synthase archaeal, H subunit
    smart00248
    Location:1078 → 1106
    ANK; ankyrin repeats
    COG0666
    Location:1042 → 1268
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00105
    Location:1723 → 1785
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:392 → 516
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam03938
    Location:790 → 889
    OmpH; Outer membrane protein (OmpH-like)
    pfam12796
    Location:301 → 390
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1349 → 1402
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:431 → 460
    ANK; ANK repeat [structural motif]

  3. NM_198010.2 → NP_932127.2  ankyrin repeat domain-containing protein 17 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
    Source sequence(s)
    AC140220, AC162171
    Consensus CDS
    CCDS57353.1
    UniProtKB/TrEMBL
    E9Q804, E9QKG6
    Related
    ENSMUSP00000080587.7, ENSMUST00000081914.13
    Conserved Domains (6) summary
    COG0666
    Location:791 → 1017
    ANKYR; Ankyrin repeat [Signal transduction mechanisms]
    cd00105
    Location:1472 → 1534
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    cd00204
    Location:392 → 516
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:301 → 390
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:1098 → 1151
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:431 → 460
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    90375025..90517133 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006535289.5 → XP_006535352.3  ankyrin repeat domain-containing protein 17 isoform X3

    UniProtKB/TrEMBL
    E9Q804
    Conserved Domains (7) summary
    smart00248
    Location:1117 → 1145
    ANK; ankyrin repeats
    PHA03095
    Location:1132 → 1395
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:2147 → 2483
    PHA03247; large tegument protein UL36; Provisional
    cd00105
    Location:1762 → 1824
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    sd00045
    Location:722 → 751
    ANK; ANK repeat [structural motif]
    pfam03154
    Location:1931 → 2359
    Atrophin-1; Atrophin-1 family
    pfam12796
    Location:855 → 946
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_006535287.5 → XP_006535350.3  ankyrin repeat domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    E9Q804
    Related
    ENSMUSP00000128960.4, ENSMUST00000168058.7
    Conserved Domains (8) summary
    PHA03095
    Location:1383 → 1646
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:2398 → 2734
    PHA03247; large tegument protein UL36; Provisional
    cd00105
    Location:2013 → 2075
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    sd00045
    Location:722 → 751
    ANK; ANK repeat [structural motif]
    pfam03154
    Location:2182 → 2610
    Atrophin-1; Atrophin-1 family
    pfam12796
    Location:855 → 946
    Ank_2; Ankyrin repeats (3 copies)
    pfam03938
    Location:1081 → 1180
    OmpH; Outer membrane protein (OmpH-like)
    cl39094
    Location:1361 → 1399
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_006535288.5 → XP_006535351.3  ankyrin repeat domain-containing protein 17 isoform X2

    UniProtKB/TrEMBL
    E9Q804
    Conserved Domains (8) summary
    PHA03095
    Location:1384 → 1647
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:2399 → 2735
    PHA03247; large tegument protein UL36; Provisional
    cd00105
    Location:2014 → 2076
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    sd00045
    Location:722 → 751
    ANK; ANK repeat [structural motif]
    pfam03154
    Location:2183 → 2611
    Atrophin-1; Atrophin-1 family
    pfam12796
    Location:855 → 946
    Ank_2; Ankyrin repeats (3 copies)
    pfam03938
    Location:1081 → 1180
    OmpH; Outer membrane protein (OmpH-like)
    cl39094
    Location:1362 → 1400
    Ank_2; Ankyrin repeats (3 copies)

  4. XM_006535290.4 → XP_006535353.1  ankyrin repeat domain-containing protein 17 isoform X5

    UniProtKB/TrEMBL
    A0A0G2JDZ9, E9Q804
    Related
    ENSMUSP00000142575.2, ENSMUST00000197021.2
    Conserved Domains (7) summary
    PHA03095
    Location:984 → 1247
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1953 → 2335
    PHA03247; large tegument protein UL36; Provisional
    cd00105
    Location:1614 → 1676
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    sd00045
    Location:322 → 351
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:455 → 546
    Ank_2; Ankyrin repeats (3 copies)
    pfam03938
    Location:681 → 780
    OmpH; Outer membrane protein (OmpH-like)
    cl39094
    Location:962 → 1000
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_036165629.1 → XP_036021522.1  ankyrin repeat domain-containing protein 17 isoform X6

    UniProtKB/TrEMBL
    E9Q804
    Conserved Domains (7) summary
    PHA03095
    Location:967 → 1230
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:1936 → 2318
    PHA03247; large tegument protein UL36; Provisional
    sd00045
    Location:305 → 334
    ANK; ANK repeat [structural motif]
    pfam03938
    Location:664 → 763
    OmpH; Outer membrane protein (OmpH-like)
    pfam12796
    Location:438 → 529
    Ank_2; Ankyrin repeats (3 copies)
    cd22502
    Location:1596 → 1666
    KH-I_ANKRD17; type I K homology (KH) RNA-binding domain found in ankyrin repeat domain-containing protein 17 (ANKRD17) and similar proteins
    cl39094
    Location:945 → 983
    Ank_2; Ankyrin repeats (3 copies)

  6. XM_011249595.4 → XP_011247897.3  ankyrin repeat domain-containing protein 17 isoform X4

    UniProtKB/TrEMBL
    E9Q804
    Conserved Domains (8) summary
    smart00248
    Location:1369 → 1397
    ANK; ankyrin repeats
    PHA03095
    Location:1384 → 1647
    PHA03095; ankyrin-like protein; Provisional
    PHA03247
    Location:2142 → 2510
    PHA03247; large tegument protein UL36; Provisional
    cd00105
    Location:2014 → 2076
    KH-I; K homology RNA-binding domain, type I. KH binds single-stranded RNA or DNA. It is found in a wide variety of proteins including ribosomal proteins, transcription factors and post-transcriptional modifiers of mRNA. There are two different KH domains that ...
    sd00045
    Location:722 → 751
    ANK; ANK repeat [structural motif]
    pfam03154
    Location:2352 → 2606
    Atrophin-1; Atrophin-1 family
    pfam12796
    Location:855 → 946
    Ank_2; Ankyrin repeats (3 copies)
    pfam03938
    Location:1081 → 1180
    OmpH; Outer membrane protein (OmpH-like)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99NH0.2 GenPept UniProtKB/Swiss-Prot:Q99NH0

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