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OR2G3 olfactory receptor family 2 subfamily G member 3 [ Homo sapiens (human) ]

Gene ID: 81469, updated on 5-Mar-2024

Summary

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Official Symbol
OR2G3provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily G member 3provided by HGNC
Primary source
HGNC:HGNC:15008
See related
Ensembl:ENSG00000177476 AllianceGenome:HGNC:15008
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR1-33
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Orthologs
all
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Genomic context

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Location:
1q44
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (247605586..247606515)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (247042412..247043341)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (247768888..247769817)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene germinal center associated signaling and motility like Neighboring gene GCSAML antisense RNA 1 Neighboring gene olfactory receptor family 2 subfamily C member 3 Neighboring gene uncharacterized LOC102724446 Neighboring gene MPRA-validated peak835 silencer Neighboring gene olfactory receptor family 2 subfamily G member 2 Neighboring gene uncharacterized LOC124904709 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:247778261-247778824 Neighboring gene olfactory receptor family 14 subfamily L member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  2. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

General gene information

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Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
olfactory receptor 2G3
Names
olfactory receptor OR1-33

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001001914.1 → NP_001001914.1  olfactory receptor 2G3

    See identical proteins and their annotated locations for NP_001001914.1

    Status: PROVISIONAL

    Source sequence(s)
    AL606804
    Consensus CDS
    CCDS31093.1
    UniProtKB/Swiss-Prot
    B2RN64, Q5JQT1, Q6IF45, Q8NGZ4
    UniProtKB/TrEMBL
    A0A126GVV3, A0A126GVX0
    Related
    ENSP00000326301.2, ENST00000320002.3
    Conserved Domains (1) summary
    cd15947
    Location:26 → 294
    7tmA_OR2B-like; olfactory receptor subfamily 2B and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    247605586..247606515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    247042412..247043341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGZ4.1 GenPept UniProtKB/Swiss-Prot:Q8NGZ4

Gene LinkOut

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