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Rad54l2 RAD54 like 2 (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 81000, updated on 21-Apr-2024

Summary

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Official Symbol
Rad54l2provided by MGI
Official Full Name
RAD54 like 2 (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1933196
See related
Ensembl:ENSMUSG00000040661 AllianceGenome:MGI:1933196
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Arip4; Srisnf2l; D130058C05; G630026H09Rik
Summary
Enables several functions, including ATP binding activity; ATP hydrolysis activity; and transcription coregulator activity. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in nuclear speck. Is expressed in central nervous system; embryo; limb; and neural ectoderm. Orthologous to human RAD54L2 (RAD54 like 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 6.2), CNS E14 (RPKM 4.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 57.98 cM
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (106565279..106666412, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (106688080..106789213, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene glutamate receptor, metabotropic 2 Neighboring gene testis expressed gene 264 ER-phagy receptor Neighboring gene STARR-seq mESC enhancer starr_25160 Neighboring gene STARR-seq mESC enhancer starr_25163 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:106723938-106724121 Neighboring gene STARR-positive B cell enhancer ABC_E8313 Neighboring gene DDB1 and CUL4 associated factor 1 Neighboring gene STARR-positive B cell enhancer ABC_E9334 Neighboring gene STARR-positive B cell enhancer ABC_E460 Neighboring gene RNA binding motif protein 15B Neighboring gene mesencephalic astrocyte-derived neurotrophic factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression and localization of androgen receptor-interacting protein-4 in the testis. Domanskyi A, et al. Am J Physiol Endocrinol Metab, 2007 Feb. PMID 17003240
  2. An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferation. Zhang FP, et al. Mol Endocrinol, 2007 Jun. PMID 17374848
  3. Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation. Tsuchiya M, et al. Sci Rep, 2015 Sep 28. PMID 26412716, Free PMC Article
  4. Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4. Sitz JH, et al. Mol Cell Biol, 2004 Jul. PMID 15199138, Free PMC Article
  5. Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription. Rouleau N, et al. Mol Biol Cell, 2002 Jun. PMID 12058073, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. p62 is a novel binding partner for ARIP4, and that its binding regulates the cellular protein level of ARIP4 under conditions of metabolic stress.
    Title: Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation.
  2. ARIP4 is an AR coregulator in Sertoli cells in vivo, but the expression in the germ cells implies that it has also AR-independent functions in spermatogenesis.
    Title: Expression and localization of androgen receptor-interacting protein-4 in the testis.
  3. ARIP4 plays an essential role in mouse embryonic development and cell proliferation, and it appears to coordinate multiple essential biological processes, possibly through a complex chromatin remodeling system.
    Title: An adenosine triphosphatase of the sucrose nonfermenting 2 family, androgen receptor-interacting protein 4, is essential for mouse embryonic development and cell proliferation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Transposon induced (1) 
  • Gene trapped (2)  1 citation
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP-dependent chromatin remodeler activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables helicase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coregulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
helicase ARIP4
Names
HCMV-interacting protein
RAD54-like protein 2
androgen receptor-interacting protein 4
steroid receptor-interacting SNF2 domain protein
NP_109655.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030730.2 → NP_109655.2  helicase ARIP4

    Status: VALIDATED

    Source sequence(s)
    AC125188, AK143506, BF455201, CJ123928
    Consensus CDS
    CCDS40759.1
    UniProtKB/Swiss-Prot
    Q3UPJ1, Q99NG0
    UniProtKB/TrEMBL
    E9QKL0
    Related
    ENSMUSP00000045454.6, ENSMUST00000046502.7
    Conserved Domains (4) summary
    cd00046
    Location:300 → 492
    DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
    pfam00176
    Location:274 → 628
    SNF2_N; SNF2 family N-terminal domain
    pfam00271
    Location:720 → 854
    Helicase_C; Helicase conserved C-terminal domain
    pfam15662
    Location:1123 → 1234
    SPATA3; Spermatogenesis-associated protein 3 family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    106565279..106666412 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99NG0.1 GenPept UniProtKB/Swiss-Prot:Q99NG0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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