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Cemip cell migration inducing protein, hyaluronan binding [ Mus musculus (house mouse) ]

Gene ID: 80982, updated on 5-Mar-2024

Summary

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Official Symbol
Cemipprovided by MGI
Official Full Name
cell migration inducing protein, hyaluronan bindingprovided by MGI
Primary source
MGI:MGI:2443629
See related
Ensembl:ENSMUSG00000052353 AllianceGenome:MGI:2443629
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Hybid; Kiaa1199; 12H19.01.T7; 6330404C01Rik; 9930013L23Rik
Summary
Enables hyaluronic acid binding activity and hyalurononglucosaminidase activity. Involved in hyaluronan catabolic process. Located in clathrin-coated vesicle membrane. Is expressed in several structures, including nervous system; retina; and testis. Orthologous to human CEMIP (cell migration inducing hyaluronidase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary adult (RPKM 4.8), testis adult (RPKM 1.2) and 11 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 D3; 7 48.35 cM
Exon count:
32
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (83582065..83735893, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (83932857..84086693, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 3110009M11 gene Neighboring gene STARR-seq mESC enhancer starr_19414 Neighboring gene STARR-positive B cell enhancer ABC_E9696 Neighboring gene STARR-positive B cell enhancer ABC_E448 Neighboring gene talin rod domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_19417 Neighboring gene mesoderm development LRP chaperone Neighboring gene STARR-seq mESC enhancer starr_19418 Neighboring gene STARR-seq mESC enhancer starr_19420 Neighboring gene predicted gene, 30440 Neighboring gene STARR-seq mESC enhancer starr_19424 Neighboring gene STARR-seq mESC enhancer starr_19425 Neighboring gene STARR-seq mESC enhancer starr_19426 Neighboring gene abhydrolase domain containing 17C Neighboring gene predicted gene, 26708 Neighboring gene predicted gene, 53174 Neighboring gene predicted gene, 39044

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration. Chen L, et al. Nat Commun, 2023 Apr 10. PMID 37037828, Free PMC Article
  2. Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts. Schmaus A, et al. Matrix Biol, 2022 May. PMID 35405271
  3. Deletion of Hyaluronan-Binding Protein Involved in Hyaluronan Depolymerization (HYBID) Results in Attenuation of Osteoarthritis in Mice. Momoeda M, et al. Am J Pathol, 2021 Nov. PMID 34390681
  4. CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes. Deroyer C, et al. Cell Death Dis, 2019 Feb 4. PMID 30718510, Free PMC Article
  5. Targeted deletion of HYBID (hyaluronan binding protein involved in hyaluronan depolymerization/ KIAA1199/CEMIP) decreases dendritic spine density in the dentate gyrus through hyaluronan accumulation. Yoshino Y, et al. Biochem Biophys Res Commun, 2018 Sep 10. PMID 30060951

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration.
    Title: KIAA1199 deficiency enhances skeletal stem cell differentiation to osteoblasts and promotes bone regeneration.
  2. CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane.
    Title: CEMIP (KIAA1199) regulates inflammation, hyperplasia and fibrosis in osteoarthritis synovial membrane.
  3. Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts.
    Title: Sulfated hyaluronic acid inhibits the hyaluronidase CEMIP and regulates the HA metabolism, proliferation and differentiation of fibroblasts.
  4. HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth.
    Title: HYBID derived from tumor cells and tumor-associated macrophages contribute to the glioblastoma growth.
  5. CEMIP regulates the proliferation and migration of vascular smooth muscle cells in atherosclerosis through the WNT-beta-catenin signaling pathway.
    Title: CEMIP regulates the proliferation and migration of vascular smooth muscle cells in atherosclerosis through the WNT-beta-catenin signaling pathway.
  6. Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
    Title: Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection.
  7. KIAA1199 overexpression is an independent prognostic marker in non-small-cell lung cancer (NSCLC). KIAA1199 expression directly influences the expression of epithelial-mesenchymal transition (EMT) markers. KIAA1199 promotes invasion and migration in NSCLC via PI3K-Akt mediated EMT.
    Title: KIAA1199 promotes invasion and migration in non-small-cell lung cancer (NSCLC) via PI3K-Akt mediated EMT.
  8. CEMIP was overexpressed in human osteoarthritis (OA) cartilage and along chondrocytes dedifferentiation. CEMIP-regulated transdifferentiation of chondrocytes into "chondro-myo-fibroblasts" expressing alpha-SMA and type III collagen, two fibrosis markers. Moreover, these "chondro-myo-fibroblasts" were found in OA cartilage but not in healthy cartilage.
    Title: CEMIP (KIAA1199) induces a fibrosis-like process in osteoarthritic chondrocytes.
  9. The KIAA1199, a protein that plays a role in a HA degradation pathway independent of the canonical hyaluronidases such as PH20, is specifically expressed in tissue lesions in which HA is degraded.
    Title: KIAA1199 expression and hyaluronan degradation colocalize in multiple sclerosis lesions.
  10. KIAA1199 is overexpressed in pancreatic intraepithelial neoplasia.
    Title: Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (3)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ER retention sequence binding ISO
Inferred from Sequence Orthology
more info
  
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables clathrin heavy chain binding ISO
Inferred from Sequence Orthology
more info
  
enables hyaluronic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables hyaluronic acid binding ISO
Inferred from Sequence Orthology
more info
  
enables hyalurononglucosaminidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables hyalurononglucosaminidase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables hyalurononglucosaminidase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hyaluronan catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hyaluronan catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in hyaluronan metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of peptidyl-threonine phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein targeting to membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in sensory perception of sound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in clathrin-coated endocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cell migration-inducing and hyaluronan-binding protein
Names
hyaluronan binding protein involved in hyaluronan depolymerization
protein 12H19.01.T7
NP_109653.3
XP_006508416.1
XP_006508417.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030728.4 → NP_109653.3  cell migration-inducing and hyaluronan-binding protein precursor

    See identical proteins and their annotated locations for NP_109653.3

    Status: VALIDATED

    Source sequence(s)
    AC101659, AC154141, AK036809, AK162689, BC086772
    Consensus CDS
    CCDS21416.1
    UniProtKB/Swiss-Prot
    E9QJS6, Q6L9J4, Q8BI06, Q9EPQ3, Q9EPQ4
    UniProtKB/TrEMBL
    Q14AX8
    Related
    ENSMUSP00000063277.6, ENSMUST00000064174.12
    Conserved Domains (4) summary
    cd13938
    Location:141 → 303
    PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
    pfam10162
    Location:47 → 165
    G8; G8 domain
    pfam13330
    Location:325 → 403
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    cl19122
    Location:1205 → 1361
    PANDER_like; Domains similar to the Pancreatic-derived factor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    83582065..83735893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006508354.4 → XP_006508417.1  cell migration-inducing and hyaluronan-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006508417.1

    UniProtKB/Swiss-Prot
    E9QJS6, Q6L9J4, Q8BI06, Q9EPQ3, Q9EPQ4
    UniProtKB/TrEMBL
    Q14AX8
    Conserved Domains (4) summary
    cd13938
    Location:141 → 303
    PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
    pfam10162
    Location:47 → 165
    G8; G8 domain
    pfam13330
    Location:325 → 403
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    cl19122
    Location:1205 → 1361
    PANDER_like; Domains similar to the Pancreatic-derived factor

  2. XM_006508353.4 → XP_006508416.1  cell migration-inducing and hyaluronan-binding protein isoform X1

    See identical proteins and their annotated locations for XP_006508416.1

    UniProtKB/Swiss-Prot
    E9QJS6, Q6L9J4, Q8BI06, Q9EPQ3, Q9EPQ4
    UniProtKB/TrEMBL
    Q14AX8
    Conserved Domains (4) summary
    cd13938
    Location:141 → 303
    PANDER_like_TMEM2; PANDER-like domain of the transmembrane protein TMEM2
    pfam10162
    Location:47 → 165
    G8; G8 domain
    pfam13330
    Location:325 → 403
    Mucin2_WxxW; Mucin-2 protein WxxW repeating region
    cl19122
    Location:1205 → 1361
    PANDER_like; Domains similar to the Pancreatic-derived factor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BI06.4 GenPept UniProtKB/Swiss-Prot:Q8BI06

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