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Uck2 uridine-cytidine kinase 2 [ Mus musculus (house mouse) ]

Gene ID: 80914, updated on 11-Apr-2024

Summary

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Official Symbol
Uck2provided by MGI
Official Full Name
uridine-cytidine kinase 2provided by MGI
Primary source
MGI:MGI:1931744
See related
Ensembl:ENSMUSG00000026558 AllianceGenome:MGI:1931744
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
UK; UMK; Umpk; TSA903
Summary
Predicted to enable identical protein binding activity and uridine kinase activity. Predicted to be involved in UMP salvage. Predicted to act upstream of or within phosphorylation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; cranium; integumental system; nervous system; and sensory organ. Orthologous to human UCK2 (uridine-cytidine kinase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 18.8), CNS E11.5 (RPKM 15.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
1 H2.3; 1 74.61 cM
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167050464..167112657, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167222895..167285933, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 33668 Neighboring gene STARR-seq mESC enhancer starr_02941 Neighboring gene TSPY-like 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_02942 Neighboring gene STARR-positive B cell enhancer ABC_E7773 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:169172446-169172703 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:169175381-169175490 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:169175492-169175800 Neighboring gene predicted gene, 51816 Neighboring gene STARR-seq mESC enhancer starr_02945 Neighboring gene predicted gene, 46170 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:169214019-169214206 Neighboring gene microRNA 6347 Neighboring gene predicted gene 2453

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The pivotal role of uridine-cytidine kinases in pyrimidine metabolism and activation of cytotoxic nucleoside analogues in neuroblastoma. van Kuilenburg AB, et al. Biochim Biophys Acta, 2016 Sep. PMID 27239701
  2. Phosphorylation of uridine and cytidine nucleoside analogs by two human uridine-cytidine kinases. Van Rompay AR, et al. Mol Pharmacol, 2001 May. PMID 11306702
  3. Bioinformatics and cellular signaling. Papin J, et al. Curr Opin Biotechnol, 2004 Feb. PMID 15102471
  4. The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery. Baines K, et al. Autophagy Rep, 2022. PMID 35449600, Free PMC Article
  5. The antiobesity factor WDTC1 suppresses adipogenesis via the CRL4WDTC1 E3 ligase. Groh BS, et al. EMBO Rep, 2016 May. PMID 27113764, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral beta-d-N4-hydroxycytidine.
    Title: Uridine-cytidine kinase 2 potentiates the mutagenic influence of the antiviral β-d-N4-hydroxycytidine.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables cytidine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables uridine kinase activity ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in CTP salvage ISO
Inferred from Sequence Orthology
more info
  
involved_in UMP salvage ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uridine-cytidine kinase 2
Names
UCK 2
cytidine monophosphokinase 2
uridine monophosphate kinase 2
uridine monophosphokinase 2
NP_001404848.1
NP_001404849.1
NP_001404850.1
NP_001404851.1
NP_001404852.1
NP_001404853.1
NP_109649.1
XP_030099588.1
XP_036010343.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001417919.1 → NP_001404848.1  uridine-cytidine kinase 2 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC142244
    Related
    ENSMUSP00000027839.10, ENSMUST00000027839.14

  2. NM_001417920.1 → NP_001404849.1  uridine-cytidine kinase 2 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC142244

  3. NM_001417921.1 → NP_001404850.1  uridine-cytidine kinase 2 isoform d

    Status: VALIDATED

    Source sequence(s)
    AC142244

  4. NM_001417922.1 → NP_001404851.1  uridine-cytidine kinase 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC142244

  5. NM_001417923.1 → NP_001404852.1  uridine-cytidine kinase 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC142244

  6. NM_001417924.1 → NP_001404853.1  uridine-cytidine kinase 2 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC142244

  7. NM_030724.4 → NP_109649.1  uridine-cytidine kinase 2 isoform a

    See identical proteins and their annotated locations for NP_109649.1

    Status: VALIDATED

    Source sequence(s)
    AC142244
    Consensus CDS
    CCDS15455.1
    UniProtKB/Swiss-Prot
    Q99PM9
    UniProtKB/TrEMBL
    Q543C2, Q8C476
    Related
    ENSMUSP00000060202.5, ENSMUST00000053686.9
    Conserved Domains (1) summary
    cd02023
    Location:22 → 228
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    167050464..167112657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243728.1 → XP_030099588.1  uridine-cytidine kinase 2 isoform X4

    Conserved Domains (1) summary
    cd02023
    Location:35 → 176
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...

  2. XM_036154450.1 → XP_036010343.1  uridine-cytidine kinase 2 isoform X2

    UniProtKB/TrEMBL
    A0A0B4J1E5
    Conserved Domains (1) summary
    cd02023
    Location:2 → 196
    UMPK; Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PM9.1 GenPept UniProtKB/Swiss-Prot:Q99PM9

Gene LinkOut

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