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Dtx3 deltex 3, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

Gene ID: 80904, updated on 5-Mar-2024

Summary

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Official Symbol
Dtx3provided by MGI
Official Full Name
deltex 3, E3 ubiquitin ligaseprovided by MGI
Primary source
MGI:MGI:2135752
See related
Ensembl:ENSMUSG00000040415 AllianceGenome:MGI:2135752
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mg310; Deltex3
Summary
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within Notch signaling pathway. Predicted to be located in cytoplasm. Predicted to be active in nucleoplasm. Is expressed in bladder; brain; ureter; and urethra of male. Orthologous to human DTX3 (deltex E3 ubiquitin ligase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 162.2), whole brain E14.5 (RPKM 120.6) and 27 other tissues See more
Orthologs
human all
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Genomic context

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Location:
10 D3; 10 74.5 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127026242..127032367, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (127190373..127196498, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene beta-1,4-N-acetyl-galactosaminyl transferase 1 Neighboring gene solute carrier family 26, member 10 Neighboring gene Rho guanine nucleotide exchange factor 25 Neighboring gene RIKEN cDNA F420014N23 gene Neighboring gene phosphatidylinositol-5-phosphate 4-kinase, type II, gamma Neighboring gene STARR-seq mESC enhancer starr_28215 Neighboring gene kinesin family member 5A Neighboring gene predicted gene, 40800

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Murine homologs of deltex define a novel gene family involved in vertebrate Notch signaling and neurogenesis. Kishi N, et al. Int J Dev Neurosci, 2001 Feb. PMID 11226752
  2. A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Wiese CB, et al. Front Neurosci, 2012. PMID 22988430, Free PMC Article
  3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
  4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
  5. A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. Thompson CL, et al. Neuron, 2014 Jul 16. PMID 24952961, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC106339

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within Notch signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable E3 ubiquitin-protein ligase DTX3
Names
RING-type E3 ubiquitin transferase DTX3
deltex 3 homolog
mDTX3
protein deltex-3
NP_001355261.1
NP_109639.1
XP_006514397.1
XP_006514399.1
XP_006514400.1
XP_030101258.1
XP_030101259.1
XP_030101260.1
XP_030101261.1
XP_030101262.1
XP_030101263.1
XP_030101264.1
XP_030101265.1
XP_036012008.1
XP_036012009.1
XP_036012010.1
XP_036012011.1
XP_036012012.1
XP_036012013.1
XP_036012014.1
XP_036012015.1
XP_036012016.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368332.1 → NP_001355261.1  probable E3 ubiquitin-protein ligase DTX3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC144852
    Consensus CDS
    CCDS88100.1
    UniProtKB/TrEMBL
    D3YV13, Q3UFK3
    Related
    ENSMUSP00000114776.2, ENSMUST00000130855.8
    Conserved Domains (2) summary
    cd16711
    Location:166 → 206
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:213 → 347
    DTC; Deltex C-terminal domain

  2. NM_030714.2 → NP_109639.1  probable E3 ubiquitin-protein ligase DTX3 isoform 1

    See identical proteins and their annotated locations for NP_109639.1

    Status: VALIDATED

    Source sequence(s)
    BC099687
    Consensus CDS
    CCDS36078.1
    UniProtKB/Swiss-Prot
    Q4FZD3, Q80V91, Q9ER06
    UniProtKB/TrEMBL
    Q3UFK3
    Related
    ENSMUSP00000044627.8, ENSMUST00000038217.14
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 344
    DTC; Deltex C-terminal domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127026242..127032367 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030245400.1 → XP_030101260.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    UniProtKB/TrEMBL
    E9Q3J1, Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 322
    DTC; Deltex C-terminal domain

  2. XM_030245402.2 → XP_030101262.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

    UniProtKB/Swiss-Prot
    Q4FZD3, Q80V91, Q9ER06
    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 344
    DTC; Deltex C-terminal domain

  3. XM_030245401.2 → XP_030101261.1  probable E3 ubiquitin-protein ligase DTX3 isoform X3

    UniProtKB/TrEMBL
    D3YV13, Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:166 → 206
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:213 → 347
    DTC; Deltex C-terminal domain

  4. XM_036156118.1 → XP_036012011.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    UniProtKB/TrEMBL
    E9Q3J1, Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 322
    DTC; Deltex C-terminal domain

  5. XM_036156116.1 → XP_036012009.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    UniProtKB/TrEMBL
    E9Q3J1, Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 322
    DTC; Deltex C-terminal domain

  6. XM_030245403.2 → XP_030101263.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

    UniProtKB/Swiss-Prot
    Q4FZD3, Q80V91, Q9ER06
    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 344
    DTC; Deltex C-terminal domain

  7. XM_036156123.1 → XP_036012016.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

    UniProtKB/Swiss-Prot
    Q4FZD3, Q80V91, Q9ER06
    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 344
    DTC; Deltex C-terminal domain

  8. XM_036156120.1 → XP_036012013.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

    UniProtKB/Swiss-Prot
    Q4FZD3, Q80V91, Q9ER06
    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 344
    DTC; Deltex C-terminal domain

  9. XM_036156122.1 → XP_036012015.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

    UniProtKB/Swiss-Prot
    Q4FZD3, Q80V91, Q9ER06
    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 344
    DTC; Deltex C-terminal domain

  10. XM_006514334.2 → XP_006514397.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

    See identical proteins and their annotated locations for XP_006514397.1

    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:166 → 206
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:213 → 325
    DTC; Deltex C-terminal domain

  11. XM_006514337.4 → XP_006514400.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    UniProtKB/TrEMBL
    E9Q3J1, Q3UFK3
    Related
    ENSMUSP00000111937.2, ENSMUST00000116229.2
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 322
    DTC; Deltex C-terminal domain

  12. XM_036156121.1 → XP_036012014.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

    UniProtKB/Swiss-Prot
    Q4FZD3, Q80V91, Q9ER06
    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 344
    DTC; Deltex C-terminal domain

  13. XM_036156117.1 → XP_036012010.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    UniProtKB/TrEMBL
    E9Q3J1, Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 322
    DTC; Deltex C-terminal domain

  14. XM_036156119.1 → XP_036012012.1  probable E3 ubiquitin-protein ligase DTX3 isoform X3

    UniProtKB/TrEMBL
    D3YV13, Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:166 → 206
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:213 → 347
    DTC; Deltex C-terminal domain

  15. XM_036156115.1 → XP_036012008.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:166 → 206
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:213 → 325
    DTC; Deltex C-terminal domain

  16. XM_030245405.1 → XP_030101265.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

    UniProtKB/Swiss-Prot
    Q4FZD3, Q80V91, Q9ER06
    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 344
    DTC; Deltex C-terminal domain

  17. XM_030245399.2 → XP_030101259.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    UniProtKB/TrEMBL
    E9Q3J1, Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 322
    DTC; Deltex C-terminal domain

  18. XM_030245404.2 → XP_030101264.1  probable E3 ubiquitin-protein ligase DTX3 isoform X4

    UniProtKB/Swiss-Prot
    Q4FZD3, Q80V91, Q9ER06
    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 344
    DTC; Deltex C-terminal domain

  19. XM_006514336.4 → XP_006514399.1  probable E3 ubiquitin-protein ligase DTX3 isoform X1

    See identical proteins and their annotated locations for XP_006514399.1

    UniProtKB/TrEMBL
    Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:166 → 206
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:213 → 325
    DTC; Deltex C-terminal domain

  20. XM_030245398.2 → XP_030101258.1  probable E3 ubiquitin-protein ligase DTX3 isoform X2

    UniProtKB/TrEMBL
    E9Q3J1, Q3UFK3
    Conserved Domains (2) summary
    cd16711
    Location:163 → 203
    RING-HC_DTX3; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Deltex3 (DTX3) and similar proteins
    pfam18102
    Location:210 → 322
    DTC; Deltex C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80V91.2 GenPept UniProtKB/Swiss-Prot:Q80V91

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