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Zfhx4 zinc finger homeodomain 4 [ Mus musculus (house mouse) ]

Gene ID: 80892, updated on 21-Apr-2024

Summary

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Official Symbol
Zfhx4provided by MGI
Official Full Name
zinc finger homeodomain 4provided by MGI
Primary source
MGI:MGI:2137668
See related
Ensembl:ENSMUSG00000025255 AllianceGenome:MGI:2137668
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Zfh4; Zfh-4; A930021B15; C130041O22Rik
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; nervous system; retina; and skin. Orthologous to human ZFHX4 (zinc finger homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in limb E14.5 (RPKM 10.6), CNS E11.5 (RPKM 7.7) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
3 A1; 3 1.96 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (5276268..5480921)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (5218218..5415861)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06803 Neighboring gene predicted gene, 52665 Neighboring gene STARR-seq mESC enhancer starr_06804 Neighboring gene predicted gene, 17308 Neighboring gene RIKEN cDNA 2700069I18 gene Neighboring gene VISTA enhancer mm1577 Neighboring gene VISTA enhancer mm1541 Neighboring gene RIKEN cDNA 4930555M17 gene Neighboring gene peroxisomal biogenesis factor 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A homeodomain-zinc finger protein, ZFHX4, is expressed in neuronal differentiation manner and suppressed in muscle differentiation manner. Hemmi K, et al. Biol Pharm Bull, 2006 Sep. PMID 16946494
  2. Expression of zfh-4, a new member of the zinc finger-homeodomain family, in developing brain and muscle. Kostich WA, et al. Dev Dyn, 1995 Feb. PMID 7537552
  3. The mouse ZFH-4 protein contains four homeodomains and twenty-two zinc fingers. Sakata N, et al. Biochem Biophys Res Commun, 2000 Jul 5. PMID 10873665
  4. ZFHX4 interacts with the NuRD core member CHD4 and regulates the glioblastoma tumor-initiating cell state. Chudnovsky Y, et al. Cell Rep, 2014 Jan 30. PMID 24440720, Free PMC Article
  5. Behavioral abnormalities observed in Zfhx2-deficient mice. Komine Y, et al. PLoS One, 2012. PMID 23300874, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice.
    Title: Ablation of Zfhx4 results in early postnatal lethality by disrupting the respiratory center in mice.
  2. Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice.
    Title: Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
zinc finger homeobox protein 4
Names
zinc finger homeodomain protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368671.1 → NP_001355600.1  zinc finger homeobox protein 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC115031, AC118246
    UniProtKB/TrEMBL
    H3BLK8
    Conserved Domains (6) summary
    smart00389
    Location:2127 → 2182
    HOX; Homeodomain
    COG5189
    Location:1468 → 1608
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5576
    Location:2536 → 2658
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:1540 → 1564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1396 → 1416
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2226 → 2280
    Homeobox; Homeobox domain

  2. NM_030708.2 → NP_109633.2  zinc finger homeobox protein 4 isoform 2

    See identical proteins and their annotated locations for NP_109633.2

    Status: VALIDATED

    Source sequence(s)
    AC115031, AC118246, BC061199, BI988177
    Consensus CDS
    CCDS38382.1
    UniProtKB/TrEMBL
    E9Q5A7, H3BLK8
    Related
    ENSMUSP00000026284.7, ENSMUST00000026284.13
    Conserved Domains (6) summary
    smart00389
    Location:2101 → 2156
    HOX; Homeodomain
    COG5189
    Location:1442 → 1582
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5576
    Location:2510 → 2632
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:1514 → 1538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1370 → 1390
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2200 → 2254
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    5276268..5480921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163423.1 → XP_036019316.1  zinc finger homeobox protein 4 isoform X1

    UniProtKB/TrEMBL
    H3BLK8
    Conserved Domains (6) summary
    smart00389
    Location:2127 → 2182
    HOX; Homeodomain
    COG5189
    Location:1468 → 1608
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5576
    Location:2536 → 2658
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:1540 → 1564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1396 → 1416
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2226 → 2280
    Homeobox; Homeobox domain

  2. XM_006530105.5 → XP_006530168.1  zinc finger homeobox protein 4 isoform X1

    See identical proteins and their annotated locations for XP_006530168.1

    UniProtKB/TrEMBL
    H3BLK8
    Related
    ENSMUSP00000135827.2, ENSMUST00000175866.8
    Conserved Domains (6) summary
    smart00389
    Location:2127 → 2182
    HOX; Homeodomain
    COG5189
    Location:1468 → 1608
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5576
    Location:2536 → 2658
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:1540 → 1564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1396 → 1416
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2226 → 2280
    Homeobox; Homeobox domain

  3. XM_006530106.4 → XP_006530169.1  zinc finger homeobox protein 4 isoform X2

    See identical proteins and their annotated locations for XP_006530169.1

    UniProtKB/TrEMBL
    E9Q5A7, H3BLK8
    Conserved Domains (6) summary
    smart00389
    Location:2101 → 2156
    HOX; Homeodomain
    COG5189
    Location:1442 → 1582
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5576
    Location:2510 → 2632
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:1514 → 1538
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1370 → 1390
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2200 → 2254
    Homeobox; Homeobox domain

  4. XM_017319816.3 → XP_017175305.1  zinc finger homeobox protein 4 isoform X1

    UniProtKB/TrEMBL
    H3BLK8
    Conserved Domains (6) summary
    smart00389
    Location:2127 → 2182
    HOX; Homeodomain
    COG5189
    Location:1468 → 1608
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    COG5576
    Location:2536 → 2658
    COG5576; Homeodomain-containing transcription factor [Transcription]
    sd00017
    Location:1540 → 1564
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00020
    Location:1396 → 1416
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00046
    Location:2226 → 2280
    Homeobox; Homeobox domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JJN2.1 GenPept UniProtKB/Swiss-Prot:Q9JJN2

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