Dhx58 DExH-box helicase 58 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dhx58provided by MGI
Official Full Name: DExH-box helicase 58provided by MGI
Primary source: MGI:MGI:1931560
See related: Ensembl:ENSMUSG00000017830 AllianceGenome:MGI:1931560
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LPG2; Lgp2; RLR-3; D11Lgp2e; B430001I08Rik
Summary: Enables double-stranded RNA binding activity. Involved in several processes, including negative regulation of innate immune response; regulation of type I interferon production; and regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway. Acts upstream of or within response to bacterium. Located in cytoplasm. Is expressed in central nervous system and retina. Orthologous to human DHX58 (DExH-box helicase 58). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in adrenal adult (RPKM 14.6), testis adult (RPKM 12.3) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 63.52 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (100585710..100595165, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (100694884..100704271, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interferon-alpha stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis.
Title: Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis.
RIG-I-Like Receptor LGP2 Is Required for Tumor Control by Radiotherapy.
Title: RIG-I-Like Receptor LGP2 Is Required for Tumor Control by Radiotherapy.
RNA Helicase LGP2 Negatively Regulates RIG-I Signaling by Preventing TRIM25-Mediated Caspase Activation and Recruitment Domain Ubiquitination.
Title: RNA Helicase LGP2 Negatively Regulates RIG-I Signaling by Preventing TRIM25-Mediated Caspase Activation and Recruitment Domain Ubiquitination.
DHX58 expression positively correlate with osteogenic process. DHX58 overexpression enhances osteogenesis via the Wnt/beta-Catenin pathway.
Title: DExH-Box helicase 58 enhances osteoblast differentiation of osteoblastic cells via Wnt/β-Catenin signaling.
These findings provide a unique mechanism for LGP2 negative regulation through TRAF suppression and extend the potential impact of LGP2 negative regulation beyond the IFN antiviral response.
Title: RNA sensor LGP2 inhibits TRAF ubiquitin ligase to negatively regulate innate immune signaling.
PACT interacts with LGP2 and this interaction is enhanced by encephalomyocarditis virus (EMCV) infection. In vitro interaction analyses using purified recombinant proteins confirmed that the single-stranded Theiler's murine encephalitis virus genome enhanced the interaction between LGP2 and PACT.
Title: PACT is required for MDA5-mediated immunoresponses triggered by Cardiovirus infection via interaction with LGP2.
L region antisense RNA of EMCV is a key determinant of innate immunity to the virus and represents an RNA that activates LGP2 associated MDA5 in virally-infected cells.
Title: Identification of an LGP2-associated MDA5 agonist in picornavirus-infected cells.
This in vivo study reveals that LGP2 is a major downregulator of the influenza A virus-triggered detrimental inflammatory response.
Title: Protective role of LGP2 in influenza virus pathogenesis.
Enhanced expression of LGP2 suppresses the IFN stimulated genes associated with cytotoxic stress by turning off the expression of IFNbeta
Title: RIG-I-like receptor LGP2 protects tumor cells from ionizing radiation.
LGP2, a host protein induced during influenza A virus infection, downregulates the host antiviral IFN response
Title: LGP2 downregulates interferon production during infection with seasonal human influenza A viruses that activate interferon regulatory factor 3.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH126579 (e-PCR)
- UniSTS:209702

AW212720 (e-PCR)
- UniSTS:180313

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISO Inferred from Sequence Orthology more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA helicase activity	ISO Inferred from Sequence Orthology more info
enables double-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables single-stranded RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables single-stranded RNA binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in antiviral innate immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytoplasmic pattern recognition receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within defense response to virus	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of MDA-5 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of RIG-I signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of RIG-I signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of RIG-I signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of innate immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of innate immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of type I interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MDA-5 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of RIG-I signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type I interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of innate immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to bacterium	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to virus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ATP-dependent RNA helicase DHX58

Names: ATP-dependent helicase LGP2; DEXH (Asp-Glu-X-His) box polypeptide 58; RIG-I-like receptor 3; RIG-I-like receptor Lgp2; RLR; RNA helicase LGP2; probable ATP-dependent RNA helicase DHX58; probable ATP-dependent helicase LGP2; protein D11Lgp2

NP_084426.2

EC 3.6.4.13

XP_036012999.1

EC 3.6.4.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_030150.2 → NP_084426.2 ATP-dependent RNA helicase DHX58

See identical proteins and their annotated locations for NP_084426.2

Status: VALIDATED

Source sequence(s)

AF316999, BP766331, BY727457

Consensus CDS

CCDS25431.1

UniProtKB/Swiss-Prot

A2A5E9, Q99J87, Q9D1X4

UniProtKB/TrEMBL

Q3U606

Related

ENSMUSP00000017974.7, ENSMUST00000017974.13

Conserved Domains (5) summary

COG1111
Location:2 → 550

MPH1; ERCC4-related helicase [Replication, recombination and repair]

cd15806
Location:552 → 664

LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor

cd12090
Location:227 → 345

MDA5_ID; Insert domain of MDA5

pfam00271
Location:350 → 475

Helicase_C; Helicase conserved C-terminal domain

pfam04851
Location:1 → 170

ResIII; Type III restriction enzyme, res subunit

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

100585710..100595165 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036157106.1 → XP_036012999.1 ATP-dependent RNA helicase DHX58 isoform X1

UniProtKB/TrEMBL

Q3U606

Conserved Domains (4) summary

COG1111
Location:53 → 481

MPH1; ERCC4-related helicase [Replication, recombination and repair]

cd15806
Location:483 → 595

LGP2_C; C-terminal domain of Laboratory of Genetics and Physiology 2 (LGP2), a cytoplasmic viral RNA receptor

cd18802
Location:280 → 414

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cl28899
Location:1 → 131

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily