Fgf20 fibroblast growth factor 20 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fgf20provided by MGI
Official Full Name: fibroblast growth factor 20provided by MGI
Primary source: MGI:MGI:1891346
See related: Ensembl:ENSMUSG00000031603 AllianceGenome:MGI:1891346
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fgf4a
Summary: Predicted to enable fibroblast growth factor receptor binding activity; growth factor activity; and receptor-receptor interaction. Involved in regulation of neuron differentiation. Acts upstream of or within inner ear receptor cell differentiation and regulation of cardiac muscle cell proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Is expressed in several structures, including cranium; integumental system; limb; sensory organ; and tooth. Human ortholog(s) of this gene implicated in renal agenesis. Orthologous to human FGF20 (fibroblast growth factor 20). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 8 A4; 8 23.89 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (40732206..40740060, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (40279166..40286953, complement)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathway.
Title: Fibroblast growth factor 20 attenuates pathological cardiac hypertrophy by activating the SIRT1 signaling pathway.
FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti.
Title: FGF20-FGFR1 signaling through MAPK and PI3K controls sensory progenitor differentiation in the organ of Corti.
Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.
Title: Analysis of FGF20-regulated genes in organ of Corti progenitors by translating ribosome affinity purification.
Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.
Title: Nephron Progenitor Maintenance Is Controlled through Fibroblast Growth Factors and Sprouty1 Interaction.
Fgf20 is only involved in differentiation. The Fgf20-KO cochlear phenotype is less severe than the Fgfr1-CKO phenotype. Sox2 and Fgf20 interact during cochlea development. Fgf20-KO organ of Corti exhibits premature differentiation.
Title: Sox2 and FGF20 interact to regulate organ of Corti hair cell and supporting cell development in a spatially-graded manner.
dermal condensation occurs via directed cell movement and Fgf20 orchestrates the early cellular and molecular events.
Title: Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation.
loss of Fgf20 delays formation of Eda-induced supernumerary mammary buds and normalizes the embryonic and postnatal hyperbranching phenotype of Eda overexpressing mice.
Title: Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty.
Data show that Fibroblast Growth Factors (FGF) 9 and 20 regulate the number of cochlear progenitors.
Title: Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling.
fibroblast growth factor 20 (Fgf20) is expressed in hair placodes and is induced by and functions downstream from epithelial ectodysplasin (Eda)/Edar and Wnt/beta-Catenin signaling to initiate formation of the underlying dermal condensation
Title: Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles.
We hypothesized that Fgf20 plays a role in specification, amplification, or maintenance of Sox2 expression in prosensory progenitors of the developing mammalian cochlea.
Title: Notch prosensory effects in the Mammalian cochlea are partially mediated by Fgf20.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation
Endonuclease-mediated (4)

General gene information

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Markers

Fgf20 (e-PCR), detects polymorphism
- UniSTS:507922

NoName (e-PCR)
- UniSTS:489251

NoName (e-PCR)
- UniSTS:495540

Fgf20 (e-PCR), detects polymorphism
- UniSTS:258266

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables fibroblast growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables fibroblast growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables receptor-receptor interaction	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear auditory receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cardiac muscle cell proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: fibroblast growth factor 20

Names: fibroblast growth factor 4a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.