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ZNF436 zinc finger protein 436 [ Homo sapiens (human) ]

Gene ID: 80818, updated on 10-Dec-2024

Summary

Official Symbol
ZNF436provided by HGNC
Official Full Name
zinc finger protein 436provided by HGNC
Primary source
HGNC:HGNC:20814
See related
Ensembl:ENSG00000125945 MIM:611703; AllianceGenome:HGNC:20814
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF; Zfp46
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in ovary (RPKM 11.7), brain (RPKM 9.2) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF436 in Genome Data Viewer
Location:
1p36.12
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (23359448..23369836, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (23192614..23203014, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (23685941..23696329, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1355 Neighboring gene heterogeneous nuclear ribonucleoprotein R Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 409 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 410 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:23670710-23671294 Neighboring gene MIR1 retrotransposon enhancer-blocking element Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:23683836-23684671 Neighboring gene Sharpr-MPRA regulatory region 11811 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 359 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 360 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 361 Neighboring gene NANOG hESC enhancer GRCh37_chr1:23697210-23697795 Neighboring gene ZNF436 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 9848 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 362 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:23709609-23709825 Neighboring gene transcription elongation factor A3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 363 Neighboring gene NANOG hESC enhancer GRCh37_chr1:23745635-23746193 Neighboring gene uncharacterized LOC124903875 Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 436 (ZNF436) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

General gene information

Clone Names

  • KIAA1710

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol  
located_in nucleoplasm  
is_active_in nucleus  

General protein information

Preferred Names
zinc finger protein 436
Names
DNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077195.2NP_001070663.1  zinc finger protein 436 isoform 1

    See identical proteins and their annotated locations for NP_001070663.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AB051497, AL109936
    Consensus CDS
    CCDS233.1
    UniProtKB/Swiss-Prot
    Q658I9, Q9C0F3
    Related
    ENSP00000313582.4, ENST00000314011.9
    Conserved Domains (4) summary
    COG5048
    Location:212467
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196216
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1354
    KRAB; KRAB box
    pfam13465
    Location:152177
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001370652.1NP_001357581.1  zinc finger protein 436 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL109936
    UniProtKB/TrEMBL
    A0AAA9YHR6
    Related
    ENSP00000518729.1, ENST00000711404.1
    Conserved Domains (5) summary
    smart00349
    Location:153
    KRAB; krueppel associated box
    COG5048
    Location:194449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:178198
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:120142
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:134159
    zf-H2C2_2; Zinc-finger double domain
  3. NM_030634.3NP_085137.1  zinc finger protein 436 isoform 1

    See identical proteins and their annotated locations for NP_085137.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AL109936, AL834485
    Consensus CDS
    CCDS233.1
    UniProtKB/Swiss-Prot
    Q658I9, Q9C0F3
    Related
    ENSP00000363736.3, ENST00000374608.3
    Conserved Domains (4) summary
    COG5048
    Location:212467
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:196216
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:1354
    KRAB; KRAB box
    pfam13465
    Location:152177
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    23359448..23369836 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_014040926.1 Reference GRCh38.p14 PATCHES

    Range
    129427..139815 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    23192614..23203014 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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