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Clca3a2 chloride channel accessory 3A2 [ Mus musculus (house mouse) ]

Gene ID: 80797, updated on 11-Apr-2024

Summary

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Official Symbol
Clca3a2provided by MGI
Official Full Name
chloride channel accessory 3A2provided by MGI
Primary source
MGI:MGI:1931471
See related
Ensembl:ENSMUSG00000028262 AllianceGenome:MGI:1931471
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Clca2
Summary
Predicted to enable intracellular calcium activated chloride channel activity. Acts upstream of or within anoikis and extrinsic apoptotic signaling pathway in absence of ligand. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; heart; and integumental system. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in large intestine adult (RPKM 6.3), mammary gland adult (RPKM 6.1) and 11 other tissues See more
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Genomic context

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Location:
3 H2; 3 69.12 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (144486340..144525385, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (144780581..144819623, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene BCL2/adenovirus E1B interacting protein 3 pseudogene Neighboring gene chloride channel accessory 3A1 Neighboring gene predicted gene, 34866 Neighboring gene nuclear receptor subfamily 5, group A, member 2 pseudogene Neighboring gene chloride channel accessory 3B Neighboring gene STARR-seq mESC enhancer starr_09185 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 pseudogene Neighboring gene predicted gene, 57838

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Induction of mouse Ca(2+)-sensitive chloride channel 2 gene during involution of mammary gland. Lee D, et al. Biochem Biophys Res Commun, 1999 Nov 2. PMID 10544033
  2. Cellular distribution and subcellular localization of mCLCA1/2 in murine gastrointestinal epithelia. Roussa E, et al. J Histochem Cytochem, 2010 Jul. PMID 20385786, Free PMC Article
  3. Real-time RT-PCR quantitation of mCLCA1 and mCLCA2 reveals differentially regulated expression in pre- and postnatal murine tissues. Leverkoehne I, et al. Histochem Cell Biol, 2002 Jul. PMID 12122442
  4. Tumor suppression by a proapoptotic calcium-activated chloride channel in mammary epithelium. Elble RC, et al. J Biol Chem, 2001 Nov 2. PMID 11483609
  5. Studies on syndrome of diabetes insipidus associated with oligosyndactyly in mice. Stewart AD, et al. Am J Physiol, 1969 Oct. PMID 4309975

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The apical membrane localization and overall distribution pattern of mCLCA2 favor a transmembrane protein implicated in transepithelial ion transport and protein secretion.
    Title: Cellular distribution and subcellular localization of mCLCA1/2 in murine gastrointestinal epithelia.
  2. Quantitation of mCLCA1 and mCLCA2 in 19 pre- and 44 postnatal murine tissues reveals differentially regulated expression in pre- and postnatal murine tissues
    Title: Real-time RT-PCR quantitation of mCLCA1 and mCLCA2 reveals differentially regulated expression in pre- and postnatal murine tissues.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables intracellularly calcium-gated chloride channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables intracellularly calcium-gated chloride channel activity ISA
Inferred from Sequence Alignment
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within anoikis IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within chloride transport ISA
Inferred from Sequence Alignment
more info
 PubMed 
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISA
Inferred from Sequence Alignment
more info
 PubMed 

General protein information

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Preferred Names
chloride channel calcium activated 3A2
Names
chloride channel calcium activated 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_030601.3 → NP_085104.1  chloride channel calcium activated 3A2 precursor

    See identical proteins and their annotated locations for NP_085104.1

    Status: VALIDATED

    Source sequence(s)
    AC137128, AF115852
    Consensus CDS
    CCDS17887.1
    UniProtKB/TrEMBL
    Q9EQR4, Q9R070
    Related
    ENSMUSP00000029929.8, ENSMUST00000029929.12
    Conserved Domains (3) summary
    TIGR00868
    Location:1 → 865
    hCaCC; calcium-activated chloride channel protein 1
    cd00198
    Location:307 → 461
    vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...
    cl19929
    Location:529 → 569
    A2M_N; MG2 domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    144486340..144525385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017319812.3 → XP_017175301.1  chloride channel calcium activated 3A2 isoform X2

    UniProtKB/TrEMBL
    Q9R070
    Conserved Domains (1) summary
    TIGR00868
    Location:15 → 802
    hCaCC; calcium-activated chloride channel protein 1

  2. XM_017319811.3 → XP_017175300.1  chloride channel calcium activated 3A2 isoform X1

    UniProtKB/TrEMBL
    Q9R070
    Conserved Domains (1) summary
    TIGR00868
    Location:15 → 810
    hCaCC; calcium-activated chloride channel protein 1

  3. XM_006502346.4 → XP_006502409.1  chloride channel calcium activated 3A2 isoform X3

    Conserved Domains (1) summary
    TIGR00868
    Location:15 → 579
    hCaCC; calcium-activated chloride channel protein 1
Nucleotide Protein Strain
Heading Accession and Version

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