Klrb1b killer cell lectin-like receptor subfamily B member 1B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Klrb1bprovided by MGI
Official Full Name: killer cell lectin-like receptor subfamily B member 1Bprovided by MGI
Primary source: MGI:MGI:107539
See related: Ensembl:ENSMUSG00000079298 AllianceGenome:MGI:107539
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ly55b; Ly55d; Klrb1d; Nkrp1b; Nkrp1d; ly-55b; ly-55d; NKR-P1B; NKR-P1D; Nkrp1-b
Summary: Enables identical protein binding activity and signaling receptor activity. Acts upstream of or within negative regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane. Is integral component of plasma membrane. Orthologous to human KLRB1 (killer cell lectin like receptor B1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 6 F3; 6 63.09 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (128790669..128803278, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (128813706..128826315, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The inhibitory NKR-P1B receptor regulates NK cell-mediated mammary tumor immunosurveillance in mice.
Title: The inhibitory NKR-P1B receptor regulates NK cell-mediated mammary tumor immunosurveillance in mice.
NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections.
Title: NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections.
Mouse cytomegalovirus m153 protein stabilizes expression of the inhibitory NKR-P1B ligand Clr-b.
Title: Mouse Cytomegalovirus m153 Protein Stabilizes Expression of the Inhibitory NKR-P1B Ligand Clr-b.
findings show that NKR-P1B negatively regulates the NK cell-mediated immune response during murine cytomegalovirus Infection
Title: Expansion and Protection by a Virus-Specific NK Cell Subset Lacking Expression of the Inhibitory NKR-P1B Receptor during Murine Cytomegalovirus Infection.
The intention is to provide the basis for conducting structural studies of the inhibitory Nkrp1b protein
Title: Recombinant expression, in vitro refolding and characterizing disulfide bonds of a mouse inhibitory C-type lectin-like receptor Nkrp1b.
Data suggest that killer cell lectin-like receptors NKR-P1B:Clr-b (Klrb1:Clec2d) interactions may provide a model for human hematopoietic cell transplants.
Title: Genetic investigation of MHC-independent missing-self recognition by mouse NK cells using an in vivo bone marrow transplantation model.
Engagement of NKR-P1C stimulates cytotoxicity of target cells, Ca2+ flux, phosphatidylinositol turnover, kinase activity, and cytokine production. In contrast, NKR-P1B engagement inhibits NK cell cytotoxicity.
Title: Functional requirements for signaling through the stimulatory and inhibitory mouse NKR-P1 (CD161) NK cell receptors.
Allelic divergence of Nkrp1b/c gene products helps explain a longstanding confusion regarding the strain-specific NK1.1 alloantigen reactivity of mouse natural killer cells.
Title: Molecular and genetic basis for strain-dependent NK1.1 alloreactivity of mouse NK cells.
cloning and characterization of a cognate ligand, Ocil, for the inhibitory NK receptors (NKR)-P1B and NKR-P1D (CD161b/d)
Title: Missing self-recognition of Ocil/Clr-b by inhibitory NKR-P1 natural killer cell receptors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation
Endonuclease-mediated (1)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of natural killer cell mediated cytotoxicity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of natural killer cell mediated cytotoxicity	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of natural killer cell mediated cytotoxicity	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cell surface	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: killer cell lectin-like receptor subfamily B member 1B allele B

Names: CD161 antigen-like family member B; NKR-P1 34; inhibitory receptor NKR-P1B; killer cell lectin-like receptor subfamily B member 1D; lymphocyte antigen 55 complex, locus B; lymphocyte antigen 55 complex, locus D; lymphocyte antigen 55b; lymphocyte antigen 55d; natural killer cell receptor protein NKR-P1B; natural killer cell receptor-P1; natural killer cell surface protein NKR-P1B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001364615.1 → NP_001351544.1 killer cell lectin-like receptor subfamily B member 1B allele B isoform 2

Status: VALIDATED

Source sequence(s)

AC102693, AK138766

Consensus CDS

CCDS90126.1

UniProtKB/TrEMBL

A0A0N4SVX6, G3UZU5

Related

ENSMUSP00000134637.2, ENSMUST00000172887.8

Conserved Domains (2) summary

cl02432
Location:94 → 138

CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain

cl25419
Location:43 → 143

PHA02642; C-type lectin-like protein; Provisional
NM_030599.4 → NP_085102.4 killer cell lectin-like receptor subfamily B member 1B allele B isoform 1

See identical proteins and their annotated locations for NP_085102.4

Status: VALIDATED

Source sequence(s)

AC102693, AK030702, AK041228

Consensus CDS

CCDS39655.1

UniProtKB/Swiss-Prot

Q3TE58, Q497F5, Q7TMP8, Q8BRW0, Q925G5, Q99JB4, Q99P32

UniProtKB/TrEMBL

A0A0N4SW10, A0A1U9W1A4

Related

ENSMUSP00000032472.5, ENSMUST00000032472.11

Conserved Domains (1) summary

cd03593
Location:94 → 212

CLECT_NK_receptors_like; C-type lectin-like domain (CTLD) of the type found in natural killer cell receptors (NKRs)