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ZNF34 zinc finger protein 34 [ Homo sapiens (human) ]

Gene ID: 80778, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF34provided by HGNC
Official Full Name
zinc finger protein 34provided by HGNC
Primary source
HGNC:HGNC:13098
See related
Ensembl:ENSG00000196378 MIM:194526; AllianceGenome:HGNC:13098
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX32
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 2.4), thyroid (RPKM 1.9) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF34 in Genome Data Viewer
Location:
8q24.3
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (144772224..144787317, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (145945720..145960823, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145997609..146012702, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 251 Neighboring gene uncharacterized LOC107986986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145987405-145988352 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:145990589-145991192 Neighboring gene uncharacterized LOC105375805 Neighboring gene Sharpr-MPRA regulatory region 4846 Neighboring gene Sharpr-MPRA regulatory region 10254 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19708 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28102 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28103 Neighboring gene RNA, 7SL, cytoplasmic 395, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:146015453-146015954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:146015955-146016454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19709 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146018867-146019815 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146021109-146022007 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146022008-146022906 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19712 Neighboring gene microRNA 6850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146024705-146025602 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146025603-146026501 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:146026502-146027399 Neighboring gene ribosomal protein L8 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28105 Neighboring gene zinc finger protein 517 Neighboring gene uncharacterized LOC100130027

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel variants in ZNF34 and other brain-expressed transcription factors are shared among early-onset MDD relatives. Subaran RL, et al. Am J Med Genet B Neuropsychiatr Genet, 2016 Apr. PMID 26823146, Free PMC Article
  2. A BanII RFLP in the ZNF34 zinc finger gene on chromosome 8. La Pillo B, et al. Hum Mol Genet, 1993 Aug. PMID 8104631
  3. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article
  4. ZFP36L2 is a cell cycle-regulated CCCH protein necessary for DNA lesion-induced S-phase arrest. Noguchi A, et al. Biol Open, 2018 Mar 12. PMID 29449217, Free PMC Article
  5. An interactome perturbation framework prioritizes damaging missense mutations for developmental disorders. Chen S, et al. Nat Genet, 2018 Jul. PMID 29892012, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. genes encoding transcription factors expressed in the brain might be an important group of major depressive disorder candidate genes.
    Title: Novel variants in ZNF34 and other brain-expressed transcription factors are shared among early-onset MDD relatives.
  2. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC10520

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 34
Names
zinc finger protein 34 (KOX 32)
zinc finger protein KOX32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286769.2 → NP_001273698.1  zinc finger protein 34 isoform 2

    See identical proteins and their annotated locations for NP_001273698.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AF235103, AL833814, W43004
    Consensus CDS
    CCDS69562.1
    UniProtKB/TrEMBL
    A0A0C4DG42
    Related
    ENSP00000396894.2, ENST00000429371.7
    Conserved Domains (3) summary
    smart00349
    Location:14 → 76
    KRAB; krueppel associated box
    COG5048
    Location:167 → 533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]

  2. NM_001286770.2 → NP_001273699.1  zinc finger protein 34 isoform 3

    See identical proteins and their annotated locations for NP_001273699.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an exon in the central coding region compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AF235103, BP199961, W43004
    Conserved Domains (6) summary
    smart00349
    Location:35 → 101
    KRAB; krueppel associated box
    COG5048
    Location:148 → 514
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:353 → 373
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:267 → 289
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:35 → 74
    KRAB; KRAB box
    pfam13465
    Location:421 → 446
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001378027.1 → NP_001364956.1  zinc finger protein 34 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF235103
    Consensus CDS
    CCDS69562.1
    UniProtKB/TrEMBL
    A0A0C4DG42
    Conserved Domains (3) summary
    smart00349
    Location:14 → 76
    KRAB; krueppel associated box
    COG5048
    Location:167 → 533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]

  4. NM_001378028.1 → NP_001364957.1  zinc finger protein 34 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AF235103
    Consensus CDS
    CCDS69562.1
    UniProtKB/TrEMBL
    A0A0C4DG42
    Conserved Domains (3) summary
    smart00349
    Location:14 → 76
    KRAB; krueppel associated box
    COG5048
    Location:167 → 533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]

  5. NM_001378029.1 → NP_001364958.1  zinc finger protein 34 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AF235103
    Conserved Domains (3) summary
    smart00349
    Location:14 → 80
    KRAB; krueppel associated box
    COG5048
    Location:127 → 493
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:332 → 352
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. NM_030580.5 → NP_085057.3  zinc finger protein 34 isoform 1

    See identical proteins and their annotated locations for NP_085057.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AF235103, BC004480, W43004
    Consensus CDS
    CCDS47945.1
    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0
    Related
    ENSP00000341528.4, ENST00000343459.8
    Conserved Domains (6) summary
    smart00349
    Location:35 → 97
    KRAB; krueppel associated box
    COG5048
    Location:188 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:307 → 329
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:35 → 74
    KRAB; KRAB box
    pfam13465
    Location:461 → 486
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    144772224..144787317 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047422270.1 → XP_047278226.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  2. XM_047422271.1 → XP_047278227.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  3. XM_047422274.1 → XP_047278230.1  zinc finger protein 34 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DG42

  4. XM_047422269.1 → XP_047278225.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  5. XM_047422272.1 → XP_047278228.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  6. XM_011517314.3 → XP_011515616.1  zinc finger protein 34 isoform X1

    See identical proteins and their annotated locations for XP_011515616.1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0
    Conserved Domains (6) summary
    smart00349
    Location:35 → 97
    KRAB; krueppel associated box
    COG5048
    Location:188 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:307 → 329
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:35 → 74
    KRAB; KRAB box
    pfam13465
    Location:461 → 486
    zf-H2C2_2; Zinc-finger double domain

  7. XM_011517318.3 → XP_011515620.1  zinc finger protein 34 isoform X2

    See identical proteins and their annotated locations for XP_011515620.1

    UniProtKB/TrEMBL
    A0A0C4DG42
    Conserved Domains (3) summary
    smart00349
    Location:14 → 76
    KRAB; krueppel associated box
    COG5048
    Location:167 → 533
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:372 → 392
    ZF_C2H2; C2H2 Zn finger [structural motif]

  8. XM_047422273.1 → XP_047278229.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  9. XM_047422275.1 → XP_047278231.1  zinc finger protein 34 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DG42

  10. XM_047422276.1 → XP_047278232.1  zinc finger protein 34 isoform X3

  11. XM_017013874.2 → XP_016869363.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0
    Conserved Domains (6) summary
    smart00349
    Location:35 → 97
    KRAB; krueppel associated box
    COG5048
    Location:188 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:393 → 413
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:307 → 329
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:35 → 74
    KRAB; KRAB box
    pfam13465
    Location:461 → 486
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    145945720..145960823 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361294.1 → XP_054217269.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  2. XM_054361295.1 → XP_054217270.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0

  3. XM_054361297.1 → XP_054217272.1  zinc finger protein 34 isoform X2

    UniProtKB/TrEMBL
    A0A0C4DG42

  4. XM_054361298.1 → XP_054217273.1  zinc finger protein 34 isoform X3

  5. XM_054361296.1 → XP_054217271.1  zinc finger protein 34 isoform X1

    UniProtKB/Swiss-Prot
    D3DWN1, Q8IZ26, Q9BSZ0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZ26.3 GenPept UniProtKB/Swiss-Prot:Q8IZ26

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