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ITIH5 inter-alpha-trypsin inhibitor heavy chain 5 [ Homo sapiens (human) ]

Gene ID: 80760, updated on 3-Apr-2024

Summary

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Official Symbol
ITIH5provided by HGNC
Official Full Name
inter-alpha-trypsin inhibitor heavy chain 5provided by HGNC
Primary source
HGNC:HGNC:21449
See related
Ensembl:ENSG00000123243 MIM:609783; AllianceGenome:HGNC:21449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ITI-HC5; PP14776
Summary
This gene encodes a heavy chain component of one of the inter-alpha-trypsin inhibitor (ITI) family members. ITI proteins are involved in extracellular matrix stabilization and in the prevention of tumor metastasis. They are also structurally related plasma serine protease inhibitors and are composed of a light chain and varying numbers of heavy chains. This family member is thought to function as a tumor suppressor in breast and thyroid cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Expression
Broad expression in fat (RPKM 49.7), placenta (RPKM 32.8) and 18 other tissues See more
Orthologs
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Genomic context

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Location:
10p14
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (7559270..7666966, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (7560192..7667778, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (7601232..7708929, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376390 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:7580314-7581513 Neighboring gene uncharacterized LOC105376391 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:7583451-7584310 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:7593195-7594096 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:7594097-7594998 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr10:7677530-7678369 Neighboring gene Sharpr-MPRA regulatory region 2566 Neighboring gene inter-alpha-trypsin inhibitor heavy chain 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:7809082-7809283 Neighboring gene Kin17 DNA and RNA binding protein Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2981

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells. Rose M, et al. Cells, 2021 Apr 28. PMID 33924987, Free PMC Article
  2. Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5. Young ED, et al. Br J Cancer, 2021 Jan. PMID 33024269, Free PMC Article
  3. ITIH5 induces a shift in TGF-β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor death. Rose M, et al. Mol Carcinog, 2018 Feb. PMID 28940371
  4. Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancer. Sasaki K, et al. Clin Exp Metastasis, 2017 Apr. PMID 28289921, Free PMC Article
  5. Gene expression analysis combined with functional genomics approach identifies ITIH5 as tumor suppressor gene in cervical carcinogenesis. Dittmann J, et al. Mol Carcinog, 2017 Jun. PMID 28059468

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells.
    Title: The ECM Modulator ITIH5 Affects Cell Adhesion, Motility and Chemotherapeutic Response of Basal/Squamous-Like (BASQ) Bladder Cancer Cells.
  2. ITIH5, a p53-responsive gene, inhibits the growth and metastasis of melanoma cells by downregulating the transcriptional activity of KLF4.
    Title: ITIH5, a p53-responsive gene, inhibits the growth and metastasis of melanoma cells by downregulating the transcriptional activity of KLF4.
  3. Genetic effects on planum temporale asymmetry and their limited relevance to neurodevelopmental disorders, intelligence or educational attainment.
    Title: Genetic effects on planum temporale asymmetry and their limited relevance to neurodevelopmental disorders, intelligence or educational attainment.
  4. Inter-alpha-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural Stabilizer of Hyaluronan That Modulates Biological Processes in the Skin.
    Title: Inter-α-Trypsin Inhibitor Heavy Chain 5 (ITIH5) Is a Natural Stabilizer of Hyaluronan That Modulates Biological Processes in the Skin.
  5. Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5.
    Title: Suppression of pancreatic cancer liver metastasis by secretion-deficient ITIH5.
  6. The results demonstrated that the MIR31HG-miR-31-ITIH5-PIK3CG pathway plays a role in the pathogenesis of Hirschsprung disease.
    Title: Aberrant expression of LncRNA-MIR31HG regulates cell migration and proliferation by affecting miR-31 and miR-31* in Hirschsprung's disease.
  7. ITIH5 may represent a novel modulator of TGF-beta superfamily signaling.
    Title: ITIH5 induces a shift in TGF-β superfamily signaling involving Endoglin and reduces risk for breast cancer metastasis and tumor death.
  8. Results provide evidence that ITIH5 triggers a reprogramming of breast cancer cells through global epigenetic changes effecting DAPK1. ITIH5 may represent an ECM modulator in epithelial breast tissue mediating suppression of tumor initiating cancer cell characteristics which are thought being responsible for the metastasis of breast cancer.
    Title: ITIH5 mediates epigenetic reprogramming of breast cancer cells.
  9. Low ITIH5 expression is associated with liver metastasis in pancreatic cancer.
    Title: Genome-wide in vivo RNAi screen identifies ITIH5 as a metastasis suppressor in pancreatic cancer.
  10. This is the first study so far showing a putative tumor suppressive function of ITIH5 in cervical carcinogenesis.
    Title: Gene expression analysis combined with functional genomics approach identifies ITIH5 as tumor suppressor gene in cervical carcinogenesis.
Submit: New GeneRIF Correction See all GeneRIFs (25)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC10848, DKFZp686F0145

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in hyaluronan metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix HDA PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
inter-alpha-trypsin inhibitor heavy chain H5
Names
ITI heavy chain H5
inter-alpha (globulin) inhibitor H5
inter-alpha-trypsin inhibitor heavy chain family member 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047199.1 RefSeqGene

    Range
    5033..112729
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001001851.3 → NP_001001851.1  inter-alpha-trypsin inhibitor heavy chain H5 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001001851.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks several 3' exons and has an alternate 3' exon, compared to variant 1. The encoded isoform (3) has an alternate and shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AK027375, AK027831, AL355374, BC004282, DA246953
    UniProtKB/TrEMBL
    G5E9D8
    Related
    ENSP00000380332.2, ENST00000397145.6
    Conserved Domains (2) summary
    cd01461
    Location:292 → 473
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam08487
    Location:51 → 157
    VIT; Vault protein inter-alpha-trypsin domain

  2. NM_030569.7 → NP_085046.5  inter-alpha-trypsin inhibitor heavy chain H5 isoform 1 precursor

    See identical proteins and their annotated locations for NP_085046.5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL355374, AL833203, AY238437, BQ183379, DA246953, KF570249
    Consensus CDS
    CCDS31139.2
    UniProtKB/Swiss-Prot
    Q5T664, Q5T665, Q5T666, Q6AI60, Q6UXB7, Q86UX2, Q8TF48, Q8WYV2, Q96K70
    UniProtKB/TrEMBL
    C9J2H1
    Related
    ENSP00000380333.3, ENST00000397146.7
    Conserved Domains (3) summary
    cd01461
    Location:292 → 473
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:716 → 909
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    pfam08487
    Location:51 → 157
    VIT; Vault protein inter-alpha-trypsin domain

  3. NM_032817.6 → NP_116206.4  inter-alpha-trypsin inhibitor heavy chain H5 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks several 5' exons and has an alternate 5' exon, compared to variant 1. The encoded isoform (2) has an alternate and shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL355374, BC004282, BQ183379, DA833541, DB079183, KF570249
    Consensus CDS
    CCDS31140.2
    UniProtKB/TrEMBL
    A0A096LP62
    Related
    ENSP00000485414.1, ENST00000613909.4
    Conserved Domains (2) summary
    cd01461
    Location:78 → 259
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:502 → 695
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    7559270..7666966 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011519713.4 → XP_011518015.1  inter-alpha-trypsin inhibitor heavy chain H5 isoform X1

    UniProtKB/Swiss-Prot
    Q5T664, Q5T665, Q5T666, Q6AI60, Q6UXB7, Q86UX2, Q8TF48, Q8WYV2, Q96K70
    Conserved Domains (3) summary
    cd01461
    Location:292 → 498
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam06668
    Location:741 → 934
    ITI_HC_C; Inter-alpha-trypsin inhibitor heavy chain C-terminus
    pfam08487
    Location:51 → 157
    VIT; Vault protein inter-alpha-trypsin domain

  2. XM_011519714.4 → XP_011518016.1  inter-alpha-trypsin inhibitor heavy chain H5 isoform X2

    Conserved Domains (2) summary
    cd01461
    Location:292 → 498
    vWA_interalpha_trypsin_inhibitor; vWA_interalpha trypsin inhibitor (ITI): ITI is a glycoprotein composed of three polypeptides- two heavy chains and one light chain (bikunin). Bikunin confers the protease-inhibitor function while the heavy chains are involved in rendering stability to ...
    pfam08487
    Location:51 → 157
    VIT; Vault protein inter-alpha-trypsin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    7560192..7667778 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366839.1 → XP_054222814.1  inter-alpha-trypsin inhibitor heavy chain H5 isoform X1

  2. XM_054366840.1 → XP_054222815.1  inter-alpha-trypsin inhibitor heavy chain H5 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86UX2.2 GenPept UniProtKB/Swiss-Prot:Q86UX2

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