Rnf34 ring finger protein 34 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rnf34provided by MGI
Official Full Name: ring finger protein 34provided by MGI
Primary source: MGI:MGI:2153340
See related: Ensembl:ENSMUSG00000029474 AllianceGenome:MGI:2153340
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RIFF
Summary: Predicted to enable several functions, including p53 binding activity; ubiquitin protein ligase activity; and ubiquitin protein ligase binding activity. Involved in cellular response to cold; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of oxygen metabolic process. Predicted to be located in nuclear body. Predicted to be active in cytoplasm and plasma membrane. Is expressed in several structures, including central nervous system; dorsal root ganglion; genitourinary system; and sensory organ. Orthologous to human RNF34 (ring finger protein 34). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 23.5), testis adult (RPKM 20.9) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 5 F; 5 62.62 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	5	NC_000071.7 (122988270..123007008)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	5	NC_000071.6 (122850112..122868945)

Chromosome 5 - NC_000071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF34 ablation promotes cerebrovascular remodeling and hypertension by increasing NADPH-derived ROS generation.
Title: RNF34 ablation promotes cerebrovascular remodeling and hypertension by increasing NADPH-derived ROS generation.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

General gene information

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Markers

C88279 (e-PCR)
- UniSTS:207873

AW536122 (e-PCR)
- UniSTS:179260

AW061037 (e-PCR)
- UniSTS:179265

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol phosphate binding	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin protein ligase activity	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin-protein transferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cold	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of signal transduction by p53 class mediator	ISO Inferred from Sequence Orthology more info
involved_in nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein K48-linked ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein K48-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in regulation of oxygen metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ubiquitin-dependent protein catabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF34

Names: RING finger protein RIFF; RING-type E3 ubiquitin transferase RNF34; phafin 1

NP_001404837.1

EC 2.3.2.27

NP_001404838.1

EC 2.3.2.27

NP_085041.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001417908.1 → NP_001404837.1 E3 ubiquitin-protein ligase RNF34 isoform 2

Status: VALIDATED

Source sequence(s)

AC115728, AC121564
NM_001417909.1 → NP_001404838.1 E3 ubiquitin-protein ligase RNF34 isoform 3

Status: VALIDATED

Source sequence(s)

AC115728, AC121564
NM_030564.2 → NP_085041.1 E3 ubiquitin-protein ligase RNF34 isoform 1

See identical proteins and their annotated locations for NP_085041.1

Status: VALIDATED

Source sequence(s)

AC115728, AC121564

Consensus CDS

CCDS19656.1

UniProtKB/Swiss-Prot

Q3UV45, Q99KR6

Related

ENSMUSP00000031434.7, ENSMUST00000031434.8

Conserved Domains (2) summary

cd15769
Location:59 → 105

FYVE_CARP1; FYVE-like domain found in caspase regulator CARP1 and similar proteins

pfam13920
Location:325 → 367

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)