U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Mynn myoneurin [ Mus musculus (house mouse) ]

Gene ID: 80732, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Mynnprovided by MGI
Official Full Name
myoneurinprovided by MGI
Primary source
MGI:MGI:1931415
See related
Ensembl:ENSMUSG00000037730 AllianceGenome:MGI:1931415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Mynr; SBBIZ1; 2810011C24Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Is expressed in early conceptus and genitourinary system. Orthologous to human MYNN (myoneurin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 3.7), CNS E11.5 (RPKM 3.7) and 28 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3 A3; 3 14.27 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (30656212..30674022)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (30602087..30619873)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2661 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:30500978-30501161 Neighboring gene actin related protein T3 Neighboring gene nuclear encoded tRNA valine 8 (anticodon AAC) Neighboring gene leucine rich repeat containing 34 Neighboring gene STARR-seq mESC enhancer starr_07297 Neighboring gene leucine-rich repeats and IQ motif containing 4 Neighboring gene STARR-seq mESC enhancer starr_07298 Neighboring gene STARR-seq mESC enhancer starr_07299 Neighboring gene leucine rich repeat containing 31 Neighboring gene predicted gene 15462

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Neuromuscular expression of the BTB/POZ and zinc finger protein myoneurin. Cifuentes-Diaz C, et al. Muscle Nerve, 2004 Jan. PMID 14694499
  2. Myoneurin, a novel member of the BTB/POZ-zinc finger family highly expressed in human muscle. Alliel PM, et al. Biochem Biophys Res Commun, 2000 Jun 24. PMID 10873615
  3. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
  4. ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Medeiros de Araújo JA, et al. Development, 2021 Aug 15. PMID 34351428, Free PMC Article
  5. Three-dimensional visualization of testis cord morphogenesis, a novel tubulogenic mechanism in development. Combes AN, et al. Dev Dyn, 2009 May. PMID 19334288, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
myoneurin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289621.1 → NP_001276550.1  myoneurin isoform 2

    See identical proteins and their annotated locations for NP_001276550.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AC120377, AK014315, BC065084, BF465039
    Consensus CDS
    CCDS79891.1
    UniProtKB/Swiss-Prot
    Q99MD8
    Related
    ENSMUSP00000041034.9, ENSMUST00000047502.9
    Conserved Domains (5) summary
    smart00225
    Location:25 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:304 → 324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304 → 324
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 115
    BTB; BTB/POZ domain
    pfam13465
    Location:316 → 341
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001289622.1 → NP_001276551.1  myoneurin isoform 3

    See identical proteins and their annotated locations for NP_001276551.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC120377, AK163261, BC065084, BF465039
    UniProtKB/Swiss-Prot
    Q99MD8
    Conserved Domains (4) summary
    COG5189
    Location:240 → 324
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:190 → 210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:190 → 210
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:202 → 227
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001289623.1 → NP_001276552.1  myoneurin isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of an exon and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (4) is shorter at the N-terminus and lacks an alternate internal segment compared to isoform 1.
    Source sequence(s)
    AC120377, AK030898, BC065084, BF465039
    UniProtKB/Swiss-Prot
    Q99MD8
    Conserved Domains (3) summary
    sd00017
    Location:190 → 210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:190 → 210
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:202 → 227
    zf-H2C2_2; Zinc-finger double domain

  4. NM_030557.3 → NP_085034.2  myoneurin isoform 1

    See identical proteins and their annotated locations for NP_085034.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AC120377, BC065084, BF465039
    Consensus CDS
    CCDS17284.1
    UniProtKB/Swiss-Prot
    Q6P1G7, Q8BT55, Q922I4, Q99MD8, Q9CSA0, Q9CXJ8
    Related
    ENSMUSP00000141951.2, ENSMUST00000192715.6
    Conserved Domains (5) summary
    smart00225
    Location:25 → 118
    BTB; Broad-Complex, Tramtrack and Bric a brac
    sd00017
    Location:304 → 324
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:304 → 324
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14 → 115
    BTB; BTB/POZ domain
    pfam13465
    Location:316 → 341
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    30656212..30674022
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036163419.1 → XP_036019312.1  myoneurin isoform X1

    Conserved Domains (4) summary
    COG5189
    Location:240 → 324
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:190 → 210
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:190 → 210
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:202 → 227
    zf-H2C2_2; Zinc-finger double domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MD8.2 GenPept UniProtKB/Swiss-Prot:Q99MD8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous