U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC35G2 solute carrier family 35 member G2 [ Homo sapiens (human) ]

Gene ID: 80723, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
SLC35G2provided by HGNC
Official Full Name
solute carrier family 35 member G2provided by HGNC
Primary source
HGNC:HGNC:28480
See related
Ensembl:ENSG00000168917 MIM:617812; AllianceGenome:HGNC:28480
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TMEM22
Summary
Located in Golgi apparatus and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in adrenal (RPKM 2.6), testis (RPKM 2.2) and 23 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SLC35G2 in Genome Data Viewer
Location:
3q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (136819126..136855888)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (139559143..139596547)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (136537968..136574730)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene hESC enhancers GRCh37_chr3:136470665-136471596 and GRCh37_chr3:136471597-136472528 Neighboring gene STAG1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20588 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14760 Neighboring gene sulfotransferase family 1D member 1 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14761 Neighboring gene NCK1 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20590 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14762 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20591 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20592 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:136587915-136588414 Neighboring gene NCK adaptor protein 1 Neighboring gene RAD51AP1 pseudogene 1 Neighboring gene MPRA-validated peak4840 silencer Neighboring gene IL20RB antisense RNA 1 Neighboring gene interleukin 20 receptor subunit beta

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells. Dobashi S, et al. Oncol Rep, 2009 Feb. PMID 19148500
  2. Localization, proteomics, and metabolite profiling reveal a putative vesicular transporter for UDP-glucose. Qian C, et al. Elife, 2021 Jul 16. PMID 34269178, Free PMC Article
  3. Biological insights from 108 schizophrenia-associated genetic loci. Schizophrenia Working Group of the Psychiatric Genomics Consortium. Nature, 2014 Jul 24. PMID 25056061, Free PMC Article
  4. Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. Wang AG, et al. Biochem Biophys Res Commun, 2006 Jul 7. PMID 16712791
  5. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. Simpson JC, et al. EMBO Rep, 2000 Sep. PMID 11256614, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Observational study of gene-disease association. (HuGE Navigator)
    Title: New genetic associations detected in a host response study to hepatitis B vaccine.
  2. the TMEM22/RAB37 complex is likely to play a crucial role in growth of renal cell carcinoma
    Title: Involvement of TMEM22 overexpression in the growth of renal cell carcinoma cells.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Biological insights from 108 schizophrenia-associated genetic loci.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC3295, DKFZp564K2464

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 
located_in synaptic vesicle membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
solute carrier family 35 member G2
Names
transmembrane protein 22

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001097599.2 → NP_001091068.1  solute carrier family 35 member G2

    See identical proteins and their annotated locations for NP_001091068.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC050423, BI962644, CB123281
    Consensus CDS
    CCDS3091.1
    UniProtKB/Swiss-Prot
    B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
    Conserved Domains (2) summary
    COG0697
    Location:102 → 389
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:256 → 388
    EamA; EamA-like transporter family

  2. NM_001097600.2 → NP_001091069.1  solute carrier family 35 member G2

    See identical proteins and their annotated locations for NP_001091069.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC000111, BC050423, CB123281
    Consensus CDS
    CCDS3091.1
    UniProtKB/Swiss-Prot
    B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
    Related
    ENSP00000376794.3, ENST00000393079.3
    Conserved Domains (2) summary
    COG0697
    Location:102 → 389
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:256 → 388
    EamA; EamA-like transporter family

  3. NM_025246.3 → NP_079522.2  solute carrier family 35 member G2

    See identical proteins and their annotated locations for NP_079522.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-3 encode the same protein.
    Source sequence(s)
    BC050423, CB123281
    Consensus CDS
    CCDS3091.1
    UniProtKB/Swiss-Prot
    B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
    Related
    ENSP00000400839.2, ENST00000446465.3
    Conserved Domains (2) summary
    COG0697
    Location:102 → 389
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:256 → 388
    EamA; EamA-like transporter family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    136819126..136855888
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017007290.2 → XP_016862779.1  solute carrier family 35 member G2 isoform X1

    UniProtKB/Swiss-Prot
    B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
    Conserved Domains (2) summary
    COG0697
    Location:102 → 389
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:256 → 388
    EamA; EamA-like transporter family

  2. XM_011513214.3 → XP_011511516.1  solute carrier family 35 member G2 isoform X1

    See identical proteins and their annotated locations for XP_011511516.1

    UniProtKB/Swiss-Prot
    B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
    Conserved Domains (2) summary
    COG0697
    Location:102 → 389
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:256 → 388
    EamA; EamA-like transporter family

  3. XM_017007289.2 → XP_016862778.1  solute carrier family 35 member G2 isoform X1

    UniProtKB/Swiss-Prot
    B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
    Conserved Domains (2) summary
    COG0697
    Location:102 → 389
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:256 → 388
    EamA; EamA-like transporter family

  4. XM_017007291.2 → XP_016862780.1  solute carrier family 35 member G2 isoform X1

    UniProtKB/Swiss-Prot
    B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
    Conserved Domains (2) summary
    COG0697
    Location:102 → 389
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:256 → 388
    EamA; EamA-like transporter family

  5. XM_006713773.5 → XP_006713836.1  solute carrier family 35 member G2 isoform X1

    See identical proteins and their annotated locations for XP_006713836.1

    UniProtKB/Swiss-Prot
    B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6
    Conserved Domains (2) summary
    COG0697
    Location:102 → 389
    RhaT; Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only]
    pfam00892
    Location:256 → 388
    EamA; EamA-like transporter family

  6. XM_047449027.1 → XP_047304983.1  solute carrier family 35 member G2 isoform X1

    UniProtKB/Swiss-Prot
    B2RA80, D3DNE1, Q8TBE7, Q9BWN4, Q9H0S6

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    139559143..139596547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348027.1 → XP_054204002.1  solute carrier family 35 member G2 isoform X1

  2. XM_054348028.1 → XP_054204003.1  solute carrier family 35 member G2 isoform X1

  3. XM_054348026.1 → XP_054204001.1  solute carrier family 35 member G2 isoform X1

  4. XM_054348029.1 → XP_054204004.1  solute carrier family 35 member G2 isoform X1

  5. XM_054348024.1 → XP_054203999.1  solute carrier family 35 member G2 isoform X1

  6. XM_054348025.1 → XP_054204000.1  solute carrier family 35 member G2 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TBE7.3 GenPept UniProtKB/Swiss-Prot:Q8TBE7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous