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Pbx4 pre B cell leukemia homeobox 4 [ Mus musculus (house mouse) ]

Gene ID: 80720, updated on 11-Apr-2024

Summary

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Official Symbol
Pbx4provided by MGI
Official Full Name
pre B cell leukemia homeobox 4provided by MGI
Primary source
MGI:MGI:1931321
See related
Ensembl:ENSMUSG00000031860 AllianceGenome:MGI:1931321
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2410015M21Rik
Summary
Enables sequence-specific DNA binding activity. Predicted to be involved in animal organ development; neuron development; and regulation of transcription by RNA polymerase II. Located in XY body. Is expressed in several structures, including early conceptus; eye; gonad; heart; and urinary system. Orthologous to human PBX4 (PBX homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in testis adult (RPKM 58.8), whole brain E14.5 (RPKM 4.2) and 6 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 33.92 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70285127..70324942)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69832476..69872292)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene Gem-interacting protein Neighboring gene predicted gene, 33695 Neighboring gene lysophosphatidic acid receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E2867 Neighboring gene STARR-seq mESC enhancer starr_21749 Neighboring gene predicted gene, 33746 Neighboring gene cartilage intermediate layer protein 2 Neighboring gene YjeF N-terminal domain containing 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Meis3 synergizes with Pbx4 and Hoxb1b in promoting hindbrain fates in the zebrafish. Vlachakis N, et al. Development, 2001 Apr. PMID 11262231
  2. In vivo analysis of developmentally and evolutionarily dynamic protein-DNA interactions regulating transcription of the Pgk2 gene during mammalian spermatogenesis. Yoshioka H, et al. Mol Cell Biol, 2007 Nov. PMID 17875925, Free PMC Article
  3. Pbx4, a new Pbx family member on mouse chromosome 8, is expressed during spermatogenesis. Wagner K, et al. Mech Dev, 2001 May. PMID 11335119
  4. Proteomic analysis identifies transcriptional cofactors and homeobox transcription factors as TBX18 binding proteins. Rivera-Reyes R, et al. PLoS One, 2018. PMID 30071041, Free PMC Article
  5. Hypomorphic mutation of the TALE gene Prep1 (pKnox1) causes a major reduction of Pbx and Meis proteins and a pleiotropic embryonic phenotype. Ferretti E, et al. Mol Cell Biol, 2006 Aug. PMID 16847320, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in brain development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryonic organ development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in eye development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in neuron development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of DNA-templated transcription IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IC
Inferred by Curator
more info
 PubMed 
Component Evidence Code Pubs
located_in XY body IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 

General protein information

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Preferred Names
pre-B-cell leukemia transcription factor 4
Names
homeobox protein PBX4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024954.2 → NP_001020125.1  pre-B-cell leukemia transcription factor 4 isoform 1

    See identical proteins and their annotated locations for NP_001020125.1

    Status: VALIDATED

    Source sequence(s)
    AC158564
    Consensus CDS
    CCDS22352.1
    UniProtKB/Swiss-Prot
    Q8CFL2, Q99NE8, Q99NE9
    Related
    ENSMUSP00000080219.6, ENSMUST00000081503.13
    Conserved Domains (2) summary
    cd00086
    Location:216 → 276
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:25 → 214
    PBC; PBC domain

  2. NM_001357308.1 → NP_001344237.1  pre-B-cell leukemia transcription factor 4 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC158564, BC032875
    Conserved Domains (2) summary
    cd00086
    Location:38 → 98
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:1 → 36
    PBC; PBC domain

RNA

  1. NR_151668.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158564, AK038786
    Related
    ENSMUST00000134777.10

  2. NR_151669.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158564, AK010506, BC032875
    Related
    ENSMUST00000132899.8

  3. NR_151670.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC158564, BC032875, BY097743

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    70285127..70324942
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006509800.3 → XP_006509863.1  pre-B-cell leukemia transcription factor 4 isoform X1

    Conserved Domains (2) summary
    pfam03792
    Location:25 → 214
    PBC; PBC domain
    pfam05920
    Location:216 → 249
    Homeobox_KN; Homeobox KN domain

  2. XM_030243861.2 → XP_030099721.1  pre-B-cell leukemia transcription factor 4 isoform X2

    Conserved Domains (2) summary
    cd00086
    Location:38 → 98
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:1 → 36
    PBC; PBC domain

  3. XM_030243862.2 → XP_030099722.1  pre-B-cell leukemia transcription factor 4 isoform X2

    Conserved Domains (2) summary
    cd00086
    Location:38 → 98
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:1 → 36
    PBC; PBC domain

  4. XM_030243864.1 → XP_030099724.1  pre-B-cell leukemia transcription factor 4 isoform X2

    Conserved Domains (2) summary
    cd00086
    Location:38 → 98
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam03792
    Location:1 → 36
    PBC; PBC domain

RNA

  1. XR_001778490.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99NE9.2 GenPept UniProtKB/Swiss-Prot:Q99NE9

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