Rab27b RAB27B, member RAS oncogene family [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rab27bprovided by MGI
Official Full Name: RAB27B, member RAS oncogene familyprovided by MGI
Primary source: MGI:MGI:1931295
See related: Ensembl:ENSMUSG00000024511 AllianceGenome:MGI:1931295
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2310021G14Rik; B130064M09Rik
Summary: Enables GTP binding activity and GTPase activity. Predicted to be involved in several processes, including anterograde axonal protein transport; melanosome transport; and synaptic vesicle endocytosis. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study platelet storage pool deficiency. Orthologous to human RAB27B (RAB27B, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in bladder adult (RPKM 15.6), stomach adult (RPKM 12.2) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E2; 18 43.89 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (70112202..70274704, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (69979131..70141633, complement)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
Title: RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse.
Title: Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse.
NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
Title: NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
FOXO1-Mediated Downregulation of RAB27B Leads to Decreased Exosome Secretion in Diabetic Kidneys.
Title: FOXO1-Mediated Downregulation of RAB27B Leads to Decreased Exosome Secretion in Diabetic Kidneys.
Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission.
Title: Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission.
Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth.
Title: Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth.
A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules.
Title: A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules.
miR-34c-5p could increase its intracellular level by inhibiting exosome-mediated transfer via a positive feedback loop through RAB27B, a molecule that promotes exosome shedding.
Title: miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding.
While RAB11a recruits its effector RAB11FIP3 and cytoskeletal motor Dynein, RAB27b mobilizes the effector MyRIP and motor Myosin VIIa to mediate bacterial expulsion.
Title: Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium.
this study shows that Rab27a and Rab27b double-knockout mice that are deficient in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation
Title: Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli.

Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

RH132919 (e-PCR)
- UniSTS:216202

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein activity	IEA Inferred from Electronic Annotation more info
enables GDP binding	ISO Inferred from Sequence Orthology more info
enables GTP binding	IBA Inferred from Biological aspect of Ancestor more info
enables GTP binding	IDA Inferred from Direct Assay more info	PubMed
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IDA Inferred from Direct Assay more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables myosin V binding	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in anterograde axonal protein transport	ISO Inferred from Sequence Orthology more info
involved_in exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in multivesicular body sorting pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of exocytosis	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in regulation of exocytosis	ISO Inferred from Sequence Orthology more info
involved_in synaptic vesicle endocytosis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in Golgi stack	ISO Inferred from Sequence Orthology more info
is_active_in apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in endosome	IEA Inferred from Electronic Annotation more info
is_active_in exocytic vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
is_active_in melanosome	IBA Inferred from Biological aspect of Ancestor more info
located_in melanosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in multivesicular body membrane	ISO Inferred from Sequence Orthology more info
is_active_in secretory granule	IBA Inferred from Biological aspect of Ancestor more info
is_active_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in synaptic vesicle membrane	ISO Inferred from Sequence Orthology more info
located_in trans-Golgi network transport vesicle	ISO Inferred from Sequence Orthology more info
located_in zymogen granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ras-related protein Rab-27B

NP_001076022.1

EC 3.6.5.2

NP_001289727.1

EC 3.6.5.2

NP_001289728.1

EC 3.6.5.2

NP_085031.3

EC 3.6.5.2

XP_006526427.1

EC 3.6.5.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082553.2 → NP_001076022.1 ras-related protein Rab-27B isoform 1

See identical proteins and their annotated locations for NP_001076022.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate exon structure in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).

Source sequence(s)

AC108433, AC110224, AK049854, BY127417, BY130221

Consensus CDS

CCDS29331.1

UniProtKB/Swiss-Prot

Q8CIX0, Q99P58

UniProtKB/TrEMBL

Q4VA90, Q549X4

Related

ENSMUSP00000114094.2, ENSMUST00000121693.8

Conserved Domains (2) summary

smart00175
Location:10 → 184

RAB; Rab subfamily of small GTPases

cd04127
Location:6 → 185

Rab27A; Rab GTPase family 27a (Rab27a)
NM_001302798.1 → NP_001289727.1 ras-related protein Rab-27B isoform 1

See identical proteins and their annotated locations for NP_001289727.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).

Source sequence(s)

AC108433, AC163398, AK049854, AK161136, AW455378, BY228140, BY721478

Consensus CDS

CCDS29331.1

UniProtKB/Swiss-Prot

Q8CIX0, Q99P58

UniProtKB/TrEMBL

Q4VA90, Q549X4

Related

ENSMUSP00000112807.2, ENSMUST00000117692.8

Conserved Domains (2) summary

smart00175
Location:10 → 184

RAB; Rab subfamily of small GTPases

cd04127
Location:6 → 185

Rab27A; Rab GTPase family 27a (Rab27a)
NM_001302799.1 → NP_001289728.1 ras-related protein Rab-27B isoform 2

See identical proteins and their annotated locations for NP_001289728.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice donor, which results in the use of an alternate start codon and a frameshift in the 5' coding region compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AC108433, AC163398, AK049854, AK161136, AW455378, BY228140, BY721478

UniProtKB/TrEMBL

Q05D38

Conserved Domains (1) summary

cl38936
Location:15 → 120

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
NM_030554.4 → NP_085031.3 ras-related protein Rab-27B isoform 1

See identical proteins and their annotated locations for NP_085031.3

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 3 encode the same protein (isoform 1).

Source sequence(s)

AC108433, AC163398, AK049854, AK161136, AW455378, BY228140, BY721478

Consensus CDS

CCDS29331.1

UniProtKB/Swiss-Prot

Q8CIX0, Q99P58

UniProtKB/TrEMBL

Q4VA90, Q549X4

Related

ENSMUSP00000068349.9, ENSMUST00000069749.9

Conserved Domains (2) summary

smart00175
Location:10 → 184

RAB; Rab subfamily of small GTPases

cd04127
Location:6 → 185

Rab27A; Rab GTPase family 27a (Rab27a)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

70112202..70274704 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006526364.2 → XP_006526427.1 ras-related protein Rab-27B isoform X1

See identical proteins and their annotated locations for XP_006526427.1

UniProtKB/TrEMBL

Q05D38

Conserved Domains (1) summary

cl38936
Location:15 → 120

P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases