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Wwox WW domain-containing oxidoreductase [ Mus musculus (house mouse) ]

Gene ID: 80707, updated on 5-Mar-2024

Summary

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Official Symbol
Wwoxprovided by MGI
Official Full Name
WW domain-containing oxidoreductaseprovided by MGI
Primary source
MGI:MGI:1931237
See related
Ensembl:ENSMUSG00000004637 AllianceGenome:MGI:1931237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
WOX1; 5330426P09Rik; 9030416C10Rik
Summary
Enables enzyme binding activity. Contributes to transcription coactivator activity. Involved in cellular response to transforming growth factor beta stimulus; positive regulation of extrinsic apoptotic signaling pathway; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including apoptotic signaling pathway; osteoblast differentiation; and positive regulation of extrinsic apoptotic signaling pathway in absence of ligand. Located in mitochondrion and nucleus. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including central nervous system; head mesenchyme derived from neural crest; musculoskeletal system; sensory organ; and spinal ganglion. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 12; developmental and epileptic encephalopathy 28; esophageal cancer; esophagus squamous cell carcinoma; and squamous cell carcinoma. Orthologous to human WWOX (WW domain containing oxidoreductase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cerebellum adult (RPKM 2.7), adrenal adult (RPKM 2.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Wwox in Genome Data Viewer
Location:
8 E1; 8 60.99 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (115166377..116079451)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (114439635..115352712)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933408N05 gene Neighboring gene vesicle amine transport protein 1 like Neighboring gene STARR-positive B cell enhancer ABC_E3807 Neighboring gene STARR-seq mESC enhancer starr_22773 Neighboring gene predicted gene, 30330 Neighboring gene C-type lectin domain family 3, member a Neighboring gene STARR-seq mESC enhancer starr_22775 Neighboring gene STARR-seq mESC enhancer starr_22776 Neighboring gene predicted gene 16116 Neighboring gene predicted gene, 30554 Neighboring gene predicted gene 16117 Neighboring gene STARR-seq mESC enhancer starr_22777 Neighboring gene predicted gene 16118 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:117339207-117339316 Neighboring gene predicted gene, 53457 Neighboring gene STARR-positive B cell enhancer ABC_E6688 Neighboring gene STARR-positive B cell enhancer ABC_E2274 Neighboring gene STARR-seq mESC enhancer starr_22780 Neighboring gene STARR-seq mESC enhancer starr_22781 Neighboring gene predicted gene, 39257 Neighboring gene STARR-seq mESC enhancer starr_22782 Neighboring gene STARR-seq mESC enhancer starr_22783 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:117758115-117758268 Neighboring gene STARR-seq mESC enhancer starr_22784 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:117938195-117938396 Neighboring gene STARR-seq mESC enhancer starr_22785 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:118038529-118038730 Neighboring gene STARR-seq mESC enhancer starr_22786 Neighboring gene predicted gene, 23677 Neighboring gene MAF bZIP transcription factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects. Repudi S, et al. Brain, 2021 Nov 29. PMID 33914858
  2. Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome. Zeng Z, et al. Am J Respir Cell Mol Biol, 2021 Jan. PMID 33058734, Free PMC Article
  3. WWOX somatic ablation in skeletal muscles alters glucose metabolism. Abu-Remaileh M, et al. Mol Metab, 2019 Apr. PMID 30755385, Free PMC Article
  4. Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. Hussain T, et al. Neurobiol Dis, 2019 Jan. PMID 30290271, Free PMC Article
  5. Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer. Abdeen SK, et al. Cell Death Dis, 2018 Aug 6. PMID 30082886, Free PMC Article

See all (65) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WWOX promotes osteosarcoma development via upregulation of Myc.
    Title: WWOX promotes osteosarcoma development via upregulation of Myc.
  2. Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis.
    Title: Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis.
  3. Loss of fragile WWOX gene leads to senescence escape and genome instability.
    Title: Loss of fragile WWOX gene leads to senescence escape and genome instability.
  4. WWOX activates autophagy to alleviate lipopolysaccharide-induced acute lung injury by regulating mTOR.
    Title: WWOX activates autophagy to alleviate lipopolysaccharide-induced acute lung injury by regulating mTOR.
  5. Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice.
    Title: Wwox Binding to the Murine Brca1-BRCT Domain Regulates Timing of Brip1 and CtIP Phospho-Protein Interactions with This Domain at DNA Double-Strand Breaks, and Repair Pathway Choice.
  6. Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects.
    Title: Neuronal deletion of Wwox, associated with WOREE syndrome, causes epilepsy and myelin defects.
  7. Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome.
    Title: Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome.
  8. Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3beta-mediated epileptic seizure activity in mice.
    Title: Wwox deficiency leads to neurodevelopmental and degenerative neuropathies and glycogen synthase kinase 3β-mediated epileptic seizure activity in mice.
  9. The studies uncover an unforeseen role of the tumor suppressor WWOX in whole-body glucose homeostasis and highlight the intimate relationship between cancer progression and metabolic disorders, particularly obesity and type-2 diabetes.
    Title: WWOX somatic ablation in skeletal muscles alters glucose metabolism.
  10. Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus.
    Title: Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
contributes_to transcription coactivator activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to transforming growth factor beta stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to transforming growth factor beta stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within extrinsic apoptotic signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within intrinsic apoptotic signaling pathway by p53 class mediator IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within osteoblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within skeletal system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
part_of RNA polymerase II transcription regulator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with microvillus ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WW domain-containing oxidoreductase
Names
WW-domain oxidoreductase
NP_001402027.1
NP_001402028.1
NP_001402029.1
NP_001402030.1
NP_062519.2
XP_006531573.1
XP_006531574.1
XP_006531575.1
XP_006531576.1
XP_006531578.1
XP_011246858.1
XP_011246859.1
XP_011246860.1
XP_036010283.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001415098.1 → NP_001402027.1  WW domain-containing oxidoreductase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC110576, AC129777, AC151980

  2. NM_001415099.1 → NP_001402028.1  WW domain-containing oxidoreductase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC110576, AC129777, AC151980

  3. NM_001415100.1 → NP_001402029.1  WW domain-containing oxidoreductase isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC110576, AC151980
    Related
    ENSMUSP00000125626.2, ENSMUST00000160862.8

  4. NM_001415101.1 → NP_001402030.1  WW domain-containing oxidoreductase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC110576, AC142145, AC151980

  5. NM_019573.4 → NP_062519.2  WW domain-containing oxidoreductase isoform 1

    See identical proteins and their annotated locations for NP_062519.2

    Status: VALIDATED

    Source sequence(s)
    AC110576, AC129777, AC151980
    Consensus CDS
    CCDS22691.1
    UniProtKB/Swiss-Prot
    Q8C8J6, Q91WL8, Q920Y2, Q9D2B3, Q9D339, Q9JLF5
    Related
    ENSMUSP00000004756.8, ENSMUST00000004756.14
    Conserved Domains (3) summary
    cd09809
    Location:124 → 407
    human_WWOX_like_SDR_c-like; human WWOX (WW domain-containing oxidoreductase)-like, classical (c)-like SDRs
    PRK06196
    Location:107 → 404
    PRK06196; oxidoreductase; Provisional
    cd00201
    Location:19 → 47
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    115166377..116079451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531515.5 → XP_006531578.1  WW domain-containing oxidoreductase isoform X11

    Conserved Domains (3) summary
    cd00201
    Location:60 → 90
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:18 → 47
    WW; WW domain
    cl21454
    Location:124 → 209
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  2. XM_006531510.5 → XP_006531573.1  WW domain-containing oxidoreductase isoform X1

    Conserved Domains (3) summary
    cd00201
    Location:60 → 90
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:18 → 47
    WW; WW domain
    cl21454
    Location:124 → 352
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  3. XM_006531512.4 → XP_006531575.1  WW domain-containing oxidoreductase isoform X4

    Conserved Domains (3) summary
    cd00201
    Location:60 → 90
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:18 → 47
    WW; WW domain
    cl21454
    Location:124 → 352
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  4. XM_011248556.3 → XP_011246858.1  WW domain-containing oxidoreductase isoform X2

    Conserved Domains (3) summary
    cd00201
    Location:60 → 90
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:18 → 47
    WW; WW domain
    cl21454
    Location:124 → 352
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  5. XM_011248557.4 → XP_011246859.1  WW domain-containing oxidoreductase isoform X6

    Conserved Domains (3) summary
    cd00201
    Location:60 → 90
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:18 → 47
    WW; WW domain
    cl21454
    Location:124 → 352
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  6. XM_006531511.5 → XP_006531574.1  WW domain-containing oxidoreductase isoform X3

    Conserved Domains (3) summary
    cd00201
    Location:60 → 90
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:18 → 47
    WW; WW domain
    cl21454
    Location:124 → 352
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  7. XM_011248558.4 → XP_011246860.1  WW domain-containing oxidoreductase isoform X7

    UniProtKB/Swiss-Prot
    Q91WL8
    Related
    ENSMUSP00000104736.3, ENSMUST00000109108.9
    Conserved Domains (3) summary
    cd00201
    Location:60 → 90
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:18 → 47
    WW; WW domain
    cl21454
    Location:124 → 353
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  8. XM_006531513.4 → XP_006531576.1  WW domain-containing oxidoreductase isoform X8

    Conserved Domains (3) summary
    cd00201
    Location:60 → 90
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:18 → 47
    WW; WW domain
    cl21454
    Location:124 → 352
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

  9. XM_036154390.1 → XP_036010283.1  WW domain-containing oxidoreductase isoform X10

    Conserved Domains (1) summary
    cl21454
    Location:17 → 251
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91WL8.1 GenPept UniProtKB/Swiss-Prot:Q91WL8

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