U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TNKS2 tankyrase 2 [ Homo sapiens (human) ]

Gene ID: 80351, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
TNKS2provided by HGNC
Official Full Name
tankyrase 2provided by HGNC
Primary source
HGNC:HGNC:15677
See related
Ensembl:ENSG00000107854 MIM:607128; AllianceGenome:HGNC:15677
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TNKL; ARTD6; TANK2; pART6; PARP5B; PARP5C; PARP-5b; PARP-5c
Summary
Enables NAD+ ADP-ribosyltransferase activity; enzyme binding activity; and protein ADP-ribosylase activity. Involved in several processes, including protein ADP-ribosylation; protein localization to chromosome, telomeric region; and regulation of telomere maintenance. Located in nuclear envelope; pericentriolar material; and perinuclear region of cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 15.7), placenta (RPKM 12.5) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TNKS2 in Genome Data Viewer
Location:
10q23.32
Exon count:
29
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (91798426..91865475)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (92681611..92748788)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (93558183..93625232)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902482 Neighboring gene TNKS2 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3764 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2609 Neighboring gene NANOG hESC enhancer GRCh37_chr10:93580083-93580584 Neighboring gene signal recognition particle 9 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:93640869-93641370 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:93641371-93641870 Neighboring gene Sharpr-MPRA regulatory region 9903 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:93682269-93682802 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3765 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2611 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3766 Neighboring gene fibroblast growth factor binding protein 3 Neighboring gene B-TFIID TATA-box binding protein associated factor 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. PARP5B is required for nonhomologous end joining during tumorigenesis in vivo. Wu J, et al. Mol Carcinog, 2022 Jan. PMID 34710250
  2. A FRET-based high-throughput screening platform for the discovery of chemical probes targeting the scaffolding functions of human tankyrases. Sowa ST, et al. Sci Rep, 2020 Jul 23. PMID 32704068, Free PMC Article
  3. Tankyrase 2 (TNKS2) polymorphism associated with risk in developing non-small cell lung cancer in a Chinese population. Wang Y, et al. Pathol Res Pract, 2015 Oct. PMID 26293798
  4. Isolation and physicochemical properties of tankyrase of human embryonic kidney cells of line 293. Sidorova NN, et al. Biochemistry (Mosc), 2008 Mar. PMID 18393764
  5. Immunohistochemical detection of tankyrase 2 in human breast tumors and normal renal tissue. Sidorova N, et al. Cell Tissue Res, 2006 Jan. PMID 16151859

See all (84) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
    Title: Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.
  2. miR-582-5p inhibits migration and chemo-resistant capabilities of colorectal cancer cells by targeting TNKS2.
    Title: miR-582-5p inhibits migration and chemo-resistant capabilities of colorectal cancer cells by targeting TNKS2.
  3. Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis.
    Title: Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis.
  4. Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease.
    Title: Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease.
  5. PARP5B is required for nonhomologous end joining during tumorigenesis in vivo.
    Title: PARP5B is required for nonhomologous end joining during tumorigenesis in vivo.
  6. MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.
    Title: MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.
  7. Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
    Title: Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.
  8. MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2.
    Title: MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2.
  9. Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
    Title: Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
  10. Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma.
    Title: Association of Relative Leucocyte Telomere Length and Gene Single Nucleotide Polymorphisms (TERT, TRF1, TNKS2) in Laryngeal Squamous Cell Carcinoma.
Submit: New GeneRIF Correction See all GeneRIFs (37)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables NAD+ ADP-ribosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables NAD+ ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables NAD+ ADP-ribosyltransferase activity TAS
Traceable Author Statement
more info
  
enables NAD+-protein ADP-ribosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in Wnt signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of telomere maintenance via telomere lengthening IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of canonical Wnt signaling pathway TAS
Traceable Author Statement
more info
  
involved_in positive regulation of telomere capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of telomere capping IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of telomere capping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of telomere maintenance via telomerase TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein auto-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein localization to chromosome, telomeric region IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization to chromosome, telomeric region IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein poly-ADP-ribosylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein polyubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in chromosome, telomeric region TAS
Traceable Author Statement
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in pericentriolar material IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
poly [ADP-ribose] polymerase tankyrase-2
Names
ADP-ribosyltransferase diphtheria toxin-like 6
TNKS-2
TRF1-interacting ankyrin-related ADP-ribose polymerase 2
poly [ADP-ribose] polymerase 5B
protein poly-ADP-ribosyltransferase tankyrase-2
tankyrase II
tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2
tankyrase-like protein
tankyrase-related protein
NP_079511.1
XP_011538515.1
XP_016872188.1
XP_016872189.2
XP_016872190.1
XP_047281751.1
XP_054222802.1
XP_054222803.1
XP_054222804.1
XP_054222805.1
XP_054222806.1
XP_054222807.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025235.4 → NP_079511.1  poly [ADP-ribose] polymerase tankyrase-2

    See identical proteins and their annotated locations for NP_079511.1

    Status: VALIDATED

    Source sequence(s)
    AF309033, AF438201, BQ019749
    Consensus CDS
    CCDS7417.1
    UniProtKB/Swiss-Prot
    B2RBD3, Q9H2K2, Q9H8F2, Q9HAS4
    UniProtKB/TrEMBL
    A0AA34QVI1
    Related
    ENSP00000360689.4, ENST00000371627.5
    Conserved Domains (6) summary
    PHA02876
    Location:73 → 458
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:871 → 936
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:494 → 802
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:938 → 1160
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:528 → 556
    ANK; ANK repeat [structural motif]
    pfam13857
    Location:43 → 96
    Ank_5; Ankyrin repeats (many copies)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    91798426..91865475
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540213.2 → XP_011538515.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

    UniProtKB/TrEMBL
    A0AA34QVI1
    Conserved Domains (6) summary
    PHA02876
    Location:94 → 479
    PHA02876; ankyrin repeat protein; Provisional
    cd09524
    Location:892 → 957
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:515 → 823
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:959 → 1181
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:549 → 577
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:28 → 142
    Ank_2; Ankyrin repeats (3 copies)

  2. XM_017016701.2 → XP_016872190.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X4

    Conserved Domains (3) summary
    PHA02876
    Location:94 → 479
    PHA02876; ankyrin repeat protein; Provisional
    sd00045
    Location:234 → 262
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:28 → 142
    Ank_2; Ankyrin repeats (3 copies)

  3. XM_047425795.1 → XP_047281751.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X5

  4. XM_017016699.2 → XP_016872188.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

    UniProtKB/TrEMBL
    A0AA34QVI1
    Conserved Domains (5) summary
    cd09524
    Location:764 → 829
    SAM_tankyrase1,2; SAM domain of tankyrase1,2 subfamily
    PHA03095
    Location:387 → 695
    PHA03095; ankyrin-like protein; Provisional
    cd01438
    Location:831 → 1053
    tankyrase_like; Tankyrases interact with the telomere reverse transcriptase complex (TERT). Tankyrase 1 poly-ADP-ribosylates Telomere Repeat Binding Factor 1 (TRF1) while Tankyrase 2 can poly-ADP-ribosylate itself or TRF1. The tankyrases also contain multiple ankyrin ...
    sd00045
    Location:421 → 449
    ANK; ANK repeat [structural motif]
    cl39094
    Location:100 → 365
    Ank_2; Ankyrin repeats (3 copies)

  5. XM_017016700.3 → XP_016872189.2  poly [ADP-ribose] polymerase tankyrase-2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    92681611..92748788
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366827.1 → XP_054222802.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X1

  2. XM_054366830.1 → XP_054222805.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X4

  3. XM_054366831.1 → XP_054222806.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X5

  4. XM_054366828.1 → XP_054222803.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X2

  5. XM_054366832.1 → XP_054222807.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X6

  6. XM_054366829.1 → XP_054222804.1  poly [ADP-ribose] polymerase tankyrase-2 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H2K2.1 GenPept UniProtKB/Swiss-Prot:Q9H2K2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous