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Bcl9l B cell CLL/lymphoma 9-like [ Mus musculus (house mouse) ]

Gene ID: 80288, updated on 5-Mar-2024

Summary

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Official Symbol
Bcl9lprovided by MGI
Official Full Name
B cell CLL/lymphoma 9-likeprovided by MGI
Primary source
MGI:MGI:1933114
See related
Ensembl:ENSMUSG00000063382 AllianceGenome:MGI:1933114
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B9L; BCL9-2; DLNB11
Summary
Enables beta-catenin binding activity. Acts upstream of or within several processes, including canonical Wnt signaling pathway; skeletal muscle cell differentiation; and somatic stem cell population maintenance. Located in nucleus. Is expressed in several structures, including respiratory system cartilage; sensory organ; skeleton; trunk unsegmented mesenchyme; and vibrissa. Orthologous to human BCL9L (BCL9 like). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in mammary gland adult (RPKM 17.6), lung adult (RPKM 16.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 A5.2; 9 24.84 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (44394103..44423203)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (44482738..44511906)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 103, member A1 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5064 Neighboring gene predicted gene, 22540 Neighboring gene STARR-positive B cell enhancer ABC_E5065 Neighboring gene STARR-positive B cell enhancer ABC_E10541 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44323517-44323626 Neighboring gene STARR-positive B cell enhancer ABC_E5066 Neighboring gene C-X-C motif chemokine receptor 5 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44345968-44346210 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:44348167-44348368 Neighboring gene predicted gene, 50603 Neighboring gene STARR-positive B cell enhancer mm9_chr9:44379241-44379542 Neighboring gene STARR-seq mESC enhancer starr_23977 Neighboring gene STARR-positive B cell enhancer ABC_E6727 Neighboring gene STARR-seq mESC enhancer starr_23980 Neighboring gene STARR-positive B cell enhancer ABC_E10542 Neighboring gene DEAD-box helicase 6 Neighboring gene predicted gene, 30671

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis. Zatula N, et al. Oncotarget, 2014 Aug 30. PMID 25149534, Free PMC Article
  2. BCL9-2 promotes early stages of intestinal tumor progression. Brembeck FH, et al. Gastroenterology, 2011 Oct. PMID 21703997
  3. Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers. Toya H, et al. Cancer Sci, 2007 Apr. PMID 17309600
  4. Identification and characterization of human BCL9L gene and mouse Bcl9l gene in silico. Katoh M, et al. Int J Mol Med, 2003 Oct. PMID 12964048
  5. Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells. Borrelli C, et al. Nat Commun, 2021 Mar 1. PMID 33649334, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
    Title: BCL9/BCL9L promotes tumorigenicity through immune-dependent and independent mechanisms in triple negative breast cancer.
  2. Transcriptional cofactors Bcl9, Bcl9l and Pygo1/2 act independently of beta-catenin to ensure proper enamel formation.
    Title: A cytoplasmic role of Wnt/β-catenin transcriptional cofactors Bcl9, Bcl9l, and Pygopus in tooth enamel formation.
  3. BCL9-2 induces ER positive breast cancers in vivo, regulates ER expression by a novel ss-catenin independent mechanism in breast cancer cells.
    Title: The BCL9-2 proto-oncogene governs estrogen receptor alpha expression in breast tumorigenesis.
  4. Data show that the GCM1/syncytin-B pathway is significantly downregulated in the placenta of BCL9L-deficient mice and that the fusion and differentiation of ST-II cells are blocked.
    Title: Identification of a link between Wnt/β-catenin signalling and the cell fusion pathway.
  5. BCL9-2 promotes early phases of intestinal tumor progression in humans and in transgenic mice. BCL9-2 increases the expression of a subset of canonical Wnt target genes but also regulates genes that are required for early stages of tumor progression.
    Title: BCL9-2 promotes early stages of intestinal tumor progression.
  6. We demonstrated that nuclear B9L expression was closely associated with the high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers.
    Title: Immunohistochemical expression of the beta-catenin-interacting protein B9L is associated with histological high nuclear grade and immunohistochemical ErbB2/HER-2 expression in breast cancers.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC7014

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription coactivator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within myoblast differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transforming growth factor beta receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within skeletal muscle cell differentiation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within somatic stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of beta-catenin-TCF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of beta-catenin-TCF complex ISO
Inferred from Sequence Orthology
more info
  
located_in fibrillar center ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
B-cell CLL/lymphoma 9-like protein
Names
B-cell lymphoma 9-like protein
BCL9-like protein
BCL9-related beta-catenin-binding protein
nuclear co-factor of beta-catenin signalling
protein BCL9-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357490.2 → NP_001344419.1  B-cell CLL/lymphoma 9-like protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC122428, AC125129
    Consensus CDS
    CCDS90549.1
    Related
    ENSMUSP00000151342.2, ENSMUST00000220303.2
    Conserved Domains (2) summary
    PHA03247
    Location:832 → 1314
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:358 → 392
    BCL9; B-cell lymphoma 9 protein

  2. NM_001421307.1 → NP_001408236.1  B-cell CLL/lymphoma 9-like protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC122428, AC125129
    UniProtKB/Swiss-Prot
    Q641L9, Q67FY2, Q6GQY0, Q6I7B5

  3. NM_030256.4 → NP_084532.2  B-cell CLL/lymphoma 9-like protein isoform 1

    See identical proteins and their annotated locations for NP_084532.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC125129
    Consensus CDS
    CCDS40601.1
    UniProtKB/Swiss-Prot
    Q641L9, Q67FY2, Q6GQY0, Q6I7B5
    Related
    ENSMUSP00000074516.6, ENSMUST00000074989.7
    Conserved Domains (2) summary
    PHA03247
    Location:869 → 1351
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:395 → 429
    BCL9; B-cell lymphoma 9 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    44394103..44423203
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244728.1 → XP_030100588.1  B-cell CLL/lymphoma 9-like protein isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:832 → 1314
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:358 → 392
    BCL9; B-cell lymphoma 9 protein

  2. XM_006510703.4 → XP_006510766.1  B-cell CLL/lymphoma 9-like protein isoform X1

    See identical proteins and their annotated locations for XP_006510766.1

    UniProtKB/Swiss-Prot
    Q641L9, Q67FY2, Q6GQY0, Q6I7B5
    Conserved Domains (2) summary
    PHA03247
    Location:869 → 1351
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:395 → 429
    BCL9; B-cell lymphoma 9 protein

  3. XM_006510702.5 → XP_006510765.1  B-cell CLL/lymphoma 9-like protein isoform X1

    See identical proteins and their annotated locations for XP_006510765.1

    UniProtKB/Swiss-Prot
    Q641L9, Q67FY2, Q6GQY0, Q6I7B5
    Related
    ENSMUSP00000151837.2, ENSMUST00000218183.2
    Conserved Domains (2) summary
    PHA03247
    Location:869 → 1351
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:395 → 429
    BCL9; B-cell lymphoma 9 protein

  4. XM_036155412.1 → XP_036011305.1  B-cell CLL/lymphoma 9-like protein isoform X2

    Conserved Domains (2) summary
    PHA03247
    Location:832 → 1314
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:358 → 392
    BCL9; B-cell lymphoma 9 protein

  5. XM_006510704.4 → XP_006510767.1  B-cell CLL/lymphoma 9-like protein isoform X1

    See identical proteins and their annotated locations for XP_006510767.1

    UniProtKB/Swiss-Prot
    Q641L9, Q67FY2, Q6GQY0, Q6I7B5
    Conserved Domains (2) summary
    PHA03247
    Location:869 → 1351
    PHA03247; large tegument protein UL36; Provisional
    pfam11502
    Location:395 → 429
    BCL9; B-cell lymphoma 9 protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q67FY2.1 GenPept UniProtKB/Swiss-Prot:Q67FY2

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