Parp9 poly (ADP-ribose) polymerase family, member 9 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp9provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 9provided by MGI
Primary source: MGI:MGI:1933117
See related: Ensembl:ENSMUSG00000022906 AllianceGenome:MGI:1933117
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bal; Bagl; ARTD9; PARP-9
Summary: Predicted to enable several functions, including ADP-D-ribose binding activity; STAT family protein binding activity; and pentosyltransferase activity. Involved in positive regulation of interferon-gamma-mediated signaling pathway. Predicted to be located in several cellular components, including mitochondrion; nucleoplasm; and site of DNA damage. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; brain; immune system; nasal cavity; and urinary system. Orthologous to human PARP9 (poly(ADP-ribose) polymerase family member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in large intestine adult (RPKM 7.9), liver E18 (RPKM 7.8) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 B3; 16 25.43 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (35759360..35792975)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (35938470..35972621)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production.
Title: Poly(ADP-ribose) polymerase 9 mediates early protection against Mycobacterium tuberculosis infection by regulating type I IFN production.
PARP9 and PARP14 regulate macrophage activation in macrophage cell lines treated with either IFNgamma or IL-4; PARP14 silencing induces pro-inflammatory genes and STAT1 phosphorylation in M(IFNgamma) cells, whereas it suppresses anti-inflammatory gene expression and STAT6 phosphorylation in M(IL-4) cells
Title: PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.
this study shows that Parp9-deficient mice are viable, fertile, and do not show any overt phenotype; Parp9 is dispensable for B-cell development, and that Parp9 is not essential for double-stranded DNA break repair, or that strong compensatory mechanisms exist
Title: Robust immunoglobulin class switch recombination and end joining in Parp9-deficient mice.
Data indicate that PARP polymerase PARP9-E3 ligase DTX3L interacts with STAT1 transcription factor and enhances translocation of STAT1 to the nucleus.
Title: PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection.
Data show that Parp-9 is developmentally regulated, and prominently expressed in the thymus and specific regions of the brain and gut.
Title: The macroPARP genes Parp-9 and Parp-14 are developmentally and differentially regulated in mouse tissues.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2)
Targeted (4) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Parp9 (e-PCR), detects polymorphism
- UniSTS:515912

AW214463 (e-PCR)
- UniSTS:180901

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ADP-D-ribose binding	ISO Inferred from Sequence Orthology more info
enables NAD+ ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein-C-terminal glycine ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables STAT family protein binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables enzyme inhibitor activity	ISO Inferred from Sequence Orthology more info
enables glycosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin-like protein ligase binding	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquitin-like protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in double-strand break repair	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within immune system process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of catalytic activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of chromatin binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of defense response to virus by host	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to nucleus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of type II interferon-mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of type II interferon-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tyrosine phosphorylation of STAT protein	ISO Inferred from Sequence Orthology more info
involved_in post-transcriptional regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of response to type II interferon	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
located_in site of DNA damage	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP9

Names: ADP-ribosyltransferase diphtheria toxin-like 9; b aggressive lymphoma protein homolog; poly [ADP-ribose] polymerase 9

NP_001392227.1

EC 2.4.2.30

NP_001392228.1

EC 2.4.2.30

NP_001392229.1

EC 2.4.2.30

NP_001392230.1

EC 2.4.2.30

NP_001392231.1

EC 2.4.2.30

NP_001392232.1

EC 2.4.2.30

NP_084529.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001405298.1 → NP_001392227.1 protein mono-ADP-ribosyltransferase PARP9 isoform b

Status: VALIDATED

Source sequence(s)

AC133464
NM_001405299.1 → NP_001392228.1 protein mono-ADP-ribosyltransferase PARP9 isoform a

Status: VALIDATED

Source sequence(s)

AC133464

UniProtKB/Swiss-Prot

Q6IRT6, Q8CAS9, Q99LF9
NM_001405300.1 → NP_001392229.1 protein mono-ADP-ribosyltransferase PARP9 isoform a

Status: VALIDATED

Source sequence(s)

AC133464

UniProtKB/Swiss-Prot

Q6IRT6, Q8CAS9, Q99LF9
NM_001405301.1 → NP_001392230.1 protein mono-ADP-ribosyltransferase PARP9 isoform c

Status: VALIDATED

Source sequence(s)

AC133464

UniProtKB/TrEMBL

H7BWY5
NM_001405302.1 → NP_001392231.1 protein mono-ADP-ribosyltransferase PARP9 isoform c

Status: VALIDATED

Source sequence(s)

AC133464

UniProtKB/TrEMBL

H7BWY5

Related

ENSMUSP00000023622.7, ENSMUST00000023622.13
NM_001405303.1 → NP_001392232.1 protein mono-ADP-ribosyltransferase PARP9 isoform c

Status: VALIDATED

Source sequence(s)

AC133464

UniProtKB/TrEMBL

H7BWY5
NM_030253.4 → NP_084529.1 protein mono-ADP-ribosyltransferase PARP9 isoform b

See identical proteins and their annotated locations for NP_084529.1

Status: VALIDATED

Source sequence(s)

AC133464

Consensus CDS

CCDS37326.1

UniProtKB/Swiss-Prot

Q8CAS9

Related

ENSMUSP00000110528.2, ENSMUST00000114878.8

Conserved Domains (3) summary

cd01439
Location:673 → 792

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd02903
Location:288 → 422

Macro_BAL_like; Macro domain, BAL_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). ...

cd02907
Location:83 → 261

Macro_Af1521_BAL_like; Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose ...