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Cdk5rap3 CDK5 regulatory subunit associated protein 3 [ Mus musculus (house mouse) ]

Gene ID: 80280, updated on 5-Mar-2024

Summary

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Official Symbol
Cdk5rap3provided by MGI
Official Full Name
CDK5 regulatory subunit associated protein 3provided by MGI
Primary source
MGI:MGI:1933126
See related
Ensembl:ENSMUSG00000018669 AllianceGenome:MGI:1933126
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C53; IC53; LZAP; HSF-27; MST016; 1810007E24Rik
Summary
Enables ubiquitin-like protein ligase binding activity. Involved in several processes, including definitive erythrocyte differentiation; liver development; and protein ufmylation. Acts upstream of or within positive regulation of transcription by RNA polymerase II. Located in cytoplasm. Is expressed in several structures, including brain; hemolymphoid system gland; liver; retina; and seminiferous cord. Orthologous to human CDK5RAP3 (CDK5 regulatory subunit associated protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 22.6), genital fat pad adult (RPKM 15.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 D; 11 60.16 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (96798251..96807359, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (96907425..96916531, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11523 Neighboring gene VISTA enhancer mm1299 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene VISTA enhancers mm876 and mm999 Neighboring gene STARR-seq mESC enhancer starr_30571 Neighboring gene predicted gene, 38961 Neighboring gene VISTA enhancer mm1675 Neighboring gene STARR-positive B cell enhancer ABC_E202 Neighboring gene predicted gene 11525 Neighboring gene proline rich 15-like Neighboring gene STARR-seq mESC enhancer starr_30572 Neighboring gene STARR-positive B cell enhancer ABC_E2367 Neighboring gene pyridoxine 5'-phosphate oxidase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth. Yan H, et al. Cell Prolif, 2022 May. PMID 35509151, Free PMC Article
  2. Cdk5rap3 is essential for intestinal Paneth cell development and maintenance. Quintero M, et al. Cell Death Dis, 2021 Jan 27. PMID 33504792, Free PMC Article
  3. CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury. Shen Y, et al. Int J Mol Sci, 2020 Nov 9. PMID 33182370, Free PMC Article
  4. CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial Hepatectomy Triggering Endoplasmic Reticulum Stress. Yang S, et al. Am J Pathol, 2020 Dec. PMID 32926856
  5. Caspase-mediated cleavage of C53/LZAP protein causes abnormal microtubule bundling and rupture of the nuclear envelope. Wu J, et al. Cell Res, 2013 May. PMID 23478299, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth.
    Title: CDK5RAP3, an essential regulator of checkpoint, interacts with RPL26 and maintains the stability of cell growth.
  2. Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
    Title: Cdk5rap3 is essential for intestinal Paneth cell development and maintenance.
  3. CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
    Title: CDK5RAP3, a Novel Nucleoplasmic Shuttle, Deeply Regulates HSF1-Mediated Heat Stress Response and Protects Mammary Epithelial Cells from Heat Injury.
  4. CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial Hepatectomy Triggering Endoplasmic Reticulum Stress.
    Title: CDK5RAP3 Deficiency Restrains Liver Regeneration after Partial Hepatectomy Triggering Endoplasmic Reticulum Stress.
  5. a crucial role of CDK5RAP3 in liver development and hepatic functions, is reported.
    Title: CDK5RAP3, a UFL1 substrate adaptor, is crucial for liver development.
  6. Results suggest that C53 might play a role in regulating neuronal proliferation, migration and/or differentiation in embryonic development.
    Title: Novel interaction between nuclear co-activator CBP and the CDK5 activator binding protein - C53.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC8303

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
  
enables NF-kappaB binding ISO
Inferred from Sequence Orthology
more info
  
enables cyclin binding ISO
Inferred from Sequence Orthology
more info
  
enables mitogen-activated protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-like protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like protein ligase binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic nuclear changes ISO
Inferred from Sequence Orthology
more info
  
involved_in cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in definitive erythrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endoplasmic reticulum unfolded protein response ISO
Inferred from Sequence Orthology
more info
  
involved_in liver development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic G2/M transition checkpoint ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of MAP kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein kinase activity by regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein phosphorylation ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein localization to nucleus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of signal transduction by p53 class mediator ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein ufmylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within protein ufmylation ISO
Inferred from Sequence Orthology
more info
 PubMed 
involved_in protein ufmylation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IMP
Inferred from Mutant Phenotype
more info
 PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
colocalizes_with microtubule ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
CDK5 regulatory subunit-associated protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308183.1 → NP_001295112.1  CDK5 regulatory subunit-associated protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK165494, BM211958, CK625767
    UniProtKB/TrEMBL
    Q3TSS9
    Conserved Domains (1) summary
    pfam05600
    Location:2 → 389
    DUF773; Protein of unknown function (DUF773)

  2. NM_001363255.1 → NP_001350184.1  CDK5 regulatory subunit-associated protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596384
    UniProtKB/TrEMBL
    Q3TSS9
    Conserved Domains (1) summary
    pfam05600
    Location:1 → 453
    DUF773; Protein of unknown function (DUF773)

  3. NM_001363256.1 → NP_001350185.1  CDK5 regulatory subunit-associated protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL596384
    UniProtKB/TrEMBL
    Q3TSS9
    Conserved Domains (1) summary
    pfam05600
    Location:1 → 453
    DUF773; Protein of unknown function (DUF773)

  4. NM_030248.2 → NP_084524.1  CDK5 regulatory subunit-associated protein 3 isoform 1

    See identical proteins and their annotated locations for NP_084524.1

    Status: VALIDATED

    Source sequence(s)
    AK149765, BM211958, CK625767
    Consensus CDS
    CCDS25306.1
    UniProtKB/Swiss-Prot
    Q3UE41, Q99LM2
    UniProtKB/TrEMBL
    Q3TLJ5
    Related
    ENSMUSP00000099441.5, ENSMUST00000103152.11
    Conserved Domains (1) summary
    pfam05600
    Location:5 → 500
    DUF773; Protein of unknown function (DUF773)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    96798251..96807359 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534526.5 → XP_006534589.1  CDK5 regulatory subunit-associated protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006534589.1

    UniProtKB/TrEMBL
    Q3TSS9
    Conserved Domains (1) summary
    pfam05600
    Location:1 → 453
    DUF773; Protein of unknown function (DUF773)

  2. XM_011249319.2 → XP_011247621.1  CDK5 regulatory subunit-associated protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011247621.1

    UniProtKB/TrEMBL
    Q3TSS9
    Conserved Domains (1) summary
    pfam05600
    Location:1 → 453
    DUF773; Protein of unknown function (DUF773)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99LM2.1 GenPept UniProtKB/Swiss-Prot:Q99LM2

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