RAB11FIP1 RAB11 family interacting protein 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RAB11FIP1provided by HGNC
Official Full Name: RAB11 family interacting protein 1provided by HGNC
Primary source: HGNC:HGNC:30265
See related: Ensembl:ENSG00000156675 MIM:608737; AllianceGenome:HGNC:30265
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RCP; NOEL1A; rab11-FIP1
Summary: This gene encodes one of the Rab11-family interacting proteins (Rab11-FIPs), which play a role in the Rab-11 mediated recycling of vesicles. The encoded protein may be involved in endocytic sorting, trafficking of proteins including integrin subunits and epidermal growth factor receptor (EGFR), and transport between the recycling endosome and the trans-Golgi network. Alternative splicing results in multiple transcript variants. A pseudogene is described on the X chromosome. [provided by RefSeq, Dec 2013]
Expression: Broad expression in lung (RPKM 41.1), small intestine (RPKM 24.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 8p11.23

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	8	NC_000008.11 (37858618..37899497, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	8	NC_060932.1 (38135023..38175900, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	8	NC_000008.10 (37716136..37757015, complement)

Chromosome 8 - NC_000008.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin beta1 recycling on the membrane.
Title: microRNA-205 represses breast cancer metastasis by perturbing the rab coupling protein [RCP]-mediated integrin β1 recycling on the membrane.
Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4[+] T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines.
Title: Rab11-FIP1C Is Dispensable for HIV-1 Replication in Primary CD4(+) T Cells, but Its Role Is Cell Type Dependent in Immortalized Human T-Cell Lines.
Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.
Title: Rab11-FIP1 and Rab11-FIP5 Regulate pIgR/pIgA Transcytosis through TRIM21-Mediated Polyubiquitination.
Thrombin-activated PAR1 membrane expression is regulated by Rab11a-RCP complex dissociation.
Title: Thrombin-activated PAR1 membrane expression is regulated by Rab11a-RCP complex dissociation.
Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission.
Title: Rab11FIP1 maintains Rab35 at the intercellular bridge to promote actin removal and abscission.
Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol.
Title: Zeb1 for RCP-induced oral cancer cell invasion and its suppression by resveratrol.
Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90alpha Secretion.
Title: Mutant p53 Drives Cancer Metastasis via RCP-Mediated Hsp90α Secretion.
The findings thus define that delivery of recycling cargo toward the ERC requires spatial and sequential coupling of Rab11 activity with PtdIns(3)P turnover.
Title: Rab11 activity and PtdIns(3)P turnover removes recycling cargo from endosomes.
Phosphorylation of RCP at Ser(435) by Lemur tyrosine kinase-3 (LMTK3) and of EphA2 at Ser(897) by Akt are both necessary to promote Rab14-dependent (and Rab11-independent) trafficking of EphA2 which generates cell:cell repulsion events that drive tumour cells apart.
Title: Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion.
The article focuses on the latest advances regarding the mechanisms that ensure the compartmentalized regulation of Rab11 function through its interaction with phosphoinositides. (Review)
Title: Rab11 and phosphoinositides: A synergy of signal transducers in the control of vesicular trafficking.

Submit: New GeneRIF Correction See all GeneRIFs (36)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of RAB11-FIP1C by shRNA inhibits HIV-1 infectivity in TZM-bl cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions	PubMed
	env	RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions	PubMed
Envelope surface glycoprotein gp160, precursor	env	HIV-1 Env relocalizes FIP1C to plasma membrane in a cytoplasmic tail-dependent manner	PubMed
	env	RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions	PubMed
Envelope transmembrane glycoprotein gp41	env	Second-site reversion mutation in theHIV-1 gp41 cytoplasmic tail is required to restore HIV-1 Env incorporation in YW795SL gp41 mutant in all cell types	PubMed
	env	The YW795 motif in the HIV-1 gp41 cytoplasmic tail is required for efficient cell-to-cell spread in nonpermissive cells	PubMed
	env	The YW795 motif in the HIV-1 gp41 cytoplasmic tail is required for HIV-1 Env-mediated redistribution of RAB11FIP1 and for Env incorporation in to virions	PubMed
	env	The interaction of RAB11-FIP1C with RAB14 is required for incorporation of HIV-1 Env (gp120/gp41) into virions	PubMed
	env	RAB11-FIP1C is required for HIV-1 Env (gp120/gp41) incorporation into virions, while depletion of RAB11-FIP1C by shRNA diminishes Env incorporation into virions	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

L17688 (e-PCR)
- UniSTS:74509

GDB:434012 (e-PCR)
- UniSTS:157204

RH45531 (e-PCR)
- UniSTS:51223

D18S21 (e-PCR)
- UniSTS:148514

L17705 (e-PCR)
- UniSTS:66091

D8S2119 (e-PCR)
- UniSTS:57138

D8S2279 (e-PCR)
- UniSTS:473907

G32137 (e-PCR)
- UniSTS:41288

RH98869 (e-PCR)
- UniSTS:86115

D15S1477 (e-PCR)
- UniSTS:474482

STS-H02245 (e-PCR)
- UniSTS:49012

G35510 (e-PCR)
- UniSTS:44150

RH80030 (e-PCR)
- UniSTS:87680

RH78422 (e-PCR)
- UniSTS:23171

D11S3114 (e-PCR)
- UniSTS:152207

D8S1923 (e-PCR)
- UniSTS:46740

D17S610 (e-PCR)
- UniSTS:46230

L17809 (e-PCR)
- UniSTS:39087

RCP_3679 (e-PCR)
- UniSTS:471740

L29953 (e-PCR)
- UniSTS:52164

D15S1390 (e-PCR)
- UniSTS:474340

Clone Names

FLJ22524, FLJ22622, MGC78448, DKFZp686E2214

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables small GTPase binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of adiponectin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in phagocytic vesicle membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: rab11 family-interacting protein 1

Names: RAB11 coupling protein; RAB11 family interacting protein 1 (class I); Rab effector protein; Rab-interacting recycling protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002814.3 → NP_001002814.2 rab11 family-interacting protein 1 isoform 3

See identical proteins and their annotated locations for NP_001002814.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) represents the longer transcript and encodes the longer isoform (3).

Source sequence(s)

AC130304, AK026275, AY280968, BC077720

Consensus CDS

CCDS34882.1

UniProtKB/Swiss-Prot

J3KNP0, Q307T1, Q6AZK4, Q6WKZ2, Q6WKZ4, Q6WKZ6, Q86YV4, Q8TDL1, Q9H642

Related

ENSP00000331342.4, ENST00000330843.9

Conserved Domains (2) summary

cd08682
Location:20 → 147

C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

pfam09457
Location:1226 → 1273

RBD-FIP; FIP domain
NM_025151.5 → NP_079427.4 rab11 family-interacting protein 1 isoform 1

See identical proteins and their annotated locations for NP_079427.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) lacks an alternate in-frame exon in the 3' coding region, compared to variant 3. It encodes isoform 1, which is shorter than isoform 3.

Source sequence(s)

AC130304, AK026275, BC077720

Consensus CDS

CCDS34881.1

UniProtKB/Swiss-Prot

Q6WKZ4

Related

ENSP00000287263.4, ENST00000287263.8

Conserved Domains (2) summary

cd08682
Location:20 → 147

C2_Rab11-FIP_classI; C2 domain found in Rab11-family interacting proteins (FIP) class I

pfam09457
Location:592 → 639

RBD-FIP; FIP domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000008.11 Reference GRCh38.p14 Primary Assembly

Range

37858618..37899497 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017013869.2 → XP_016869358.1 rab11 family-interacting protein 1 isoform X1

Alternate T2T-CHM13v2.0

Genomic

NC_060932.1 Alternate T2T-CHM13v2.0

Range

38135023..38175900 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054361288.1 → XP_054217263.1 rab11 family-interacting protein 1 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001002233.1: Suppressed sequence

Description

NM_001002233.1: This RefSeq was permanently suppressed because currently there is not sufficient data to support an internal transcription initiation site.