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MZT2B mitotic spindle organizing protein 2B [ Homo sapiens (human) ]

Gene ID: 80097, updated on 3-Apr-2024

Summary

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Official Symbol
MZT2Bprovided by HGNC
Official Full Name
mitotic spindle organizing protein 2Bprovided by HGNC
Primary source
HGNC:HGNC:25886
See related
Ensembl:ENSG00000152082 MIM:613450; AllianceGenome:HGNC:25886
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FAM128B; MOZART2B
Summary
Located in cytosol; microtubule cytoskeleton; and nucleoplasm. Part of gamma-tubulin large complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in fat (RPKM 10.8), colon (RPKM 10.5) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
2q21.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (130181654..130204793)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (130616158..130638685)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (130939835..130948300)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene POTE ankyrin domain family member F Neighboring gene RNA, U6 small nuclear 1049, pseudogene Neighboring gene POTEF antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:130886707-130887281 Neighboring gene mediator complex subunit 15 pseudogene 9 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16521 Neighboring gene coiled-coil domain containing 74B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16523 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:130917957-130918586 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:130921824-130922007 Neighboring gene sphingomyelin phosphodiesterase 4 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:130938087-130938883 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11953 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:130940784-130941520 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:130941521-130942257 Neighboring gene tubulin alpha 3e Neighboring gene ras homolog family member Q pseudogene 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11955 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16524 Neighboring gene NOC2 like nucleolar associated transcriptional repressor pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. MZT Proteins Form Multi-Faceted Structural Modules in the γ-Tubulin Ring Complex. Wieczorek M, et al. Cell Rep, 2020 Jun 30. PMID 32610146, Free PMC Article
  2. CDK5RAP2 stimulates microtubule nucleation by the gamma-tubulin ring complex. Choi YK, et al. J Cell Biol, 2010 Dec 13. PMID 21135143, Free PMC Article
  3. WWP1 upregulation predicts poor prognosis and promotes tumor progression by regulating ubiquitination of NDFIP1 in intrahepatic cholangiocarcinoma. Li Y, et al. Cell Death Discov, 2022 Mar 9. PMID 35264565, Free PMC Article
  4. Proteomic profiling of Myc-associated proteins. Agrawal P, et al. Cell Cycle, 2010 Dec 15. PMID 21150319, Free PMC Article
  5. Interactome profiling reveals interaction of SARS-CoV-2 NSP13 with host factor STAT1 to suppress interferon signaling. Feng K, et al. J Mol Cell Biol, 2021 Dec 30. PMID 34687317, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex.
    Title: MZT Proteins Form Multi-Faceted Structural Modules in the γ-Tubulin Ring Complex.
  2. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14346, MGC87017

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centrosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of gamma-tubulin ring complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in spindle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in spindle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
mitotic-spindle organizing protein 2B
Names
family with sequence similarity 128, member B
mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330282.2 → NP_001317211.1  mitotic-spindle organizing protein 2B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC018804
    Consensus CDS
    CCDS82511.1
    UniProtKB/TrEMBL
    B8ZZ87
    Related
    ENSP00000386419.1, ENST00000409255.1
    Conserved Domains (1) summary
    pfam12926
    Location:9 → 96
    MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

  2. NM_001330284.2 → NP_001317213.1  mitotic-spindle organizing protein 2B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC018804
    UniProtKB/TrEMBL
    H7C293
    Related
    ENSP00000404629.1, ENST00000455239.1
    Conserved Domains (1) summary
    pfam12926
    Location:9 → 57
    MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

  3. NM_025029.5 → NP_079305.2  mitotic-spindle organizing protein 2B isoform 2

    See identical proteins and their annotated locations for NP_079305.2

    Status: VALIDATED

    Source sequence(s)
    AC018804, BC014255
    Consensus CDS
    CCDS2157.1
    UniProtKB/Swiss-Prot
    Q6NZ67, Q96CG4
    UniProtKB/TrEMBL
    A0A494C0V9
    Related
    ENSP00000281871.7, ENST00000281871.11
    Conserved Domains (1) summary
    pfam12926
    Location:9 → 96
    MOZART2; Mitotic-spindle organizing gamma-tubulin ring associated

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    130181654..130204793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445915.1 → XP_047301871.1  mitotic-spindle organizing protein 2B isoform X2

  2. XM_047445914.1 → XP_047301870.1  mitotic-spindle organizing protein 2B isoform X1

  3. XM_047445916.1 → XP_047301872.1  mitotic-spindle organizing protein 2B isoform X3

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791762.1 Reference GRCh38.p14 PATCHES

    Range
    358261..381343
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054332887.1 → XP_054188862.1  mitotic-spindle organizing protein 2B isoform X2

  2. XM_054332886.1 → XP_054188861.1  mitotic-spindle organizing protein 2B isoform X1

  3. XM_054332888.1 → XP_054188863.1  mitotic-spindle organizing protein 2B isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    130616158..130638685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344025.1 → XP_054200000.1  mitotic-spindle organizing protein 2B isoform X1

  2. XM_054344026.1 → XP_054200001.1  mitotic-spindle organizing protein 2B isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6NZ67.1 GenPept UniProtKB/Swiss-Prot:Q6NZ67

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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