U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GPR157 G protein-coupled receptor 157 [ Homo sapiens (human) ]

Gene ID: 80045, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
GPR157provided by HGNC
Official Full Name
G protein-coupled receptor 157provided by HGNC
Primary source
HGNC:HGNC:23687
See related
Ensembl:ENSG00000180758 AllianceGenome:HGNC:23687
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway and radial glial cell differentiation. Predicted to be located in ciliary membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in esophagus (RPKM 10.7), skin (RPKM 5.0) and 22 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1p36.22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (9100305..9129102, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (8634357..8663346, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (9160364..9189161, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9064340-9064868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9064869-9065395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9067816-9068316 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9068317-9068817 Neighboring gene solute carrier family 2 member 7 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 207 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 111 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 112 Neighboring gene MPRA-validated peak52 silencer Neighboring gene solute carrier family 2 member 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9118073-9118573 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 113 Neighboring gene small Cajal body-specific RNA 16 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9164158-9165134 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 114 Neighboring gene MPRA-validated peak53 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9181680-9182180 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9182181-9182681 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 209 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 116 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 115 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 117 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9196849-9197350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9197351-9197850 Neighboring gene Sharpr-MPRA regulatory region 7425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 118 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 119 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:9211645-9211881 Neighboring gene MIR34A host gene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 210 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 120 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 212 Neighboring gene microRNA 34a Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9229591-9230092 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9230093-9230592 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:9240951-9241812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9241813-9242673 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 214 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 215 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:9243535-9244395 Neighboring gene long non coding transcriptional activator of miR34a

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Characterization of cDNA clones selected by the GeneMark analysis from size-fractionated cDNA libraries from human brain. Hirosawa M, et al. DNA Res, 1999 Oct 29. PMID 10574461
  2. The DNA sequence and biological annotation of human chromosome 1. Gregory SG, et al. Nature, 2006 May 18. PMID 16710414
  3. VIRMA mediates preferential m(6)A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. Yue Y, et al. Cell Discov, 2018. PMID 29507755, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ12132

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in circadian behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in radial glial cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in ciliary membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G-protein coupled receptor 157
Names
probable G-protein coupled receptor 157

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024980.5 → NP_079256.4  G-protein coupled receptor 157

    See identical proteins and their annotated locations for NP_079256.4

    Status: VALIDATED

    Source sequence(s)
    AL158048, AY768808
    Consensus CDS
    CCDS100.2
    UniProtKB/Swiss-Prot
    A2A334, Q5UAW9, Q8WWB8, Q9HA73
    UniProtKB/TrEMBL
    A8KA23
    Related
    ENSP00000366628.4, ENST00000377411.5
    Conserved Domains (1) summary
    cl21561
    Location:92 → 169
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    9100305..9129102 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263497.6 → XP_005263554.1  G-protein coupled receptor 157 isoform X2

    UniProtKB/TrEMBL
    B4E281
    Conserved Domains (1) summary
    cl21561
    Location:92 → 169
    7tm_4; Olfactory receptor

  2. XM_005263496.6 → XP_005263553.1  G-protein coupled receptor 157 isoform X1

    UniProtKB/TrEMBL
    A8KA23
    Conserved Domains (1) summary
    cl21561
    Location:92 → 169
    7tm_4; Olfactory receptor

RNA

  1. XR_007063977.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    8634357..8663346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338855.1 → XP_054194830.1  G-protein coupled receptor 157 isoform X2

  2. XM_054338854.1 → XP_054194829.1  G-protein coupled receptor 157 isoform X1

RNA

  1. XR_008486167.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5UAW9.2 GenPept UniProtKB/Swiss-Prot:Q5UAW9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous