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TMEM62 transmembrane protein 62 [ Homo sapiens (human) ]

Gene ID: 80021, updated on 3-Apr-2024

Summary

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Official Symbol
TMEM62provided by HGNC
Official Full Name
transmembrane protein 62provided by HGNC
Primary source
HGNC:HGNC:26269
See related
Ensembl:ENSG00000137842 AllianceGenome:HGNC:26269
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable hydrolase activity. Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 6.4), duodenum (RPKM 6.0) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
15q15.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (43133115..43185144)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (40940411..40992433)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (43425313..43477342)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene RPS3A pseudogene 47 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6382 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:43426442-43426653 Neighboring gene signal peptidase complex subunit 2 pseudogene 1 Neighboring gene farnesyl diphosphate synthase pseudogene 10 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:43459413-43460109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:43467716-43468216 Neighboring gene uncharacterized LOC124903478 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6383 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6384 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9310 Neighboring gene cyclin D1 binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 15360 Neighboring gene erythrocyte membrane protein band 4.2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Arachidonic acid metabolism in the human placenta: identification of a putative lipoxygenase. Jadoon A, et al. Placenta, 2014 Jun. PMID 24767823
  2. Congenital dyserythropoietic anemia type I is caused by mutations in codanin-1. Dgany O, et al. Am J Hum Genet, 2002 Dec. PMID 12434312, Free PMC Article
  3. Systematic protein-protein interaction mapping for clinically relevant human GPCRs. Sokolina K, et al. Mol Syst Biol, 2017 Mar 15. PMID 28298427, Free PMC Article
  4. A human protein-protein interaction network: a resource for annotating the proteome. Stelzl U, et al. Cell, 2005 Sep 23. PMID 16169070
  5. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. Maruyama K, et al. Gene, 1994 Jan 28. PMID 8125298

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23375

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transmembrane protein 62

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347004.1 → NP_001333933.1  transmembrane protein 62 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2), as well as variants 3-5, encodes isoform b.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  2. NM_001347005.2 → NP_001333934.1  transmembrane protein 62 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3), as well as variants 2, 4, and 5, encodes isoform b.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  3. NM_001347006.2 → NP_001333935.1  transmembrane protein 62 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 2, 3, and 5, encodes isoform b.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  4. NM_001347007.2 → NP_001333936.1  transmembrane protein 62 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 2-4, encodes isoform b.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  5. NM_001347008.1 → NP_001333937.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 7-11, encodes isoform c.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  6. NM_001347009.1 → NP_001333938.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 6 and 8-11, encodes isoform c.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  7. NM_001347010.2 → NP_001333939.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 6-7 and 9-11, encodes isoform c.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  8. NM_001347011.2 → NP_001333940.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 6-8 and 10-11, encodes isoform c.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  9. NM_001347012.2 → NP_001333941.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 6-9 and 11, encodes isoform c.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  10. NM_001347013.2 → NP_001333942.1  transmembrane protein 62 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 6-10, encodes isoform c.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  11. NM_001347014.1 → NP_001333943.1  transmembrane protein 62 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 13 and 14, encodes isoform d.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  12. NM_001347015.2 → NP_001333944.1  transmembrane protein 62 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 12 and 14, encodes isoform d.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  13. NM_001347016.2 → NP_001333945.1  transmembrane protein 62 isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 12 and 13, encodes isoform d.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  14. NM_001347017.2 → NP_001333946.1  transmembrane protein 62 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform e.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  15. NM_001347018.2 → NP_001333947.1  transmembrane protein 62 isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform e.
    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  16. NM_001347019.1 → NP_001333948.1  transmembrane protein 62 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17), as well as variants 18-20, encodes isoform f.
    Source sequence(s)
    AC068724

  17. NM_001347020.2 → NP_001333949.1  transmembrane protein 62 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18), as well as variants 17 and 19-20, encodes isoform f.
    Source sequence(s)
    AC068724

  18. NM_001347021.2 → NP_001333950.1  transmembrane protein 62 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19), as well as variants 17-18 and 20, encodes isoform f.
    Source sequence(s)
    AC068724

  19. NM_001347023.2 → NP_001333952.1  transmembrane protein 62 isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20), as well as variants 17-19, encodes isoform f.
    Source sequence(s)
    AC068724

  20. NM_001347024.1 → NP_001333953.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (21), as well as variants 22-26, encodes isoform g.
    Source sequence(s)
    AC068724

  21. NM_001347025.1 → NP_001333954.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (22), as well as variants 21 and 23-26, encodes isoform g.
    Source sequence(s)
    AC068724

  22. NM_001347026.2 → NP_001333955.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (23), as well as variants 21-22 and 24-26, encodes isoform g.
    Source sequence(s)
    AC068724

  23. NM_001347027.2 → NP_001333956.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (24), as well as variants 21-23 and 25-26, encodes isoform g.
    Source sequence(s)
    AC068724

  24. NM_001347028.2 → NP_001333957.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (25), as well as variants 21-24 and 26, encodes isoform g.
    Source sequence(s)
    AC068724

  25. NM_001347029.2 → NP_001333958.1  transmembrane protein 62 isoform g

    Status: VALIDATED

    Description
    Transcript Variant: This variant (26), as well as variants 21-25, encodes isoform g.
    Source sequence(s)
    AC068724

  26. NM_001347030.1 → NP_001333959.1  transmembrane protein 62 isoform h

    Status: VALIDATED

    Source sequence(s)
    AC068724

  27. NM_001347031.2 → NP_001333960.1  transmembrane protein 62 isoform i

    Status: VALIDATED

    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  28. NM_001347032.2 → NP_001333961.1  transmembrane protein 62 isoform j

    Status: VALIDATED

    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7
    Related
    ENSP00000458098.1, ENST00000564494.1

  29. NM_001347033.2 → NP_001333962.1  transmembrane protein 62 isoform k

    Status: VALIDATED

    Source sequence(s)
    AC068724
    UniProtKB/TrEMBL
    H3BVF7

  30. NM_001347034.2 → NP_001333963.1  transmembrane protein 62 isoform l

    Status: VALIDATED

    Source sequence(s)
    AC068724

  31. NM_024956.4 → NP_079232.3  transmembrane protein 62 isoform a

    See identical proteins and their annotated locations for NP_079232.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    BC009981
    Consensus CDS
    CCDS32210.1
    UniProtKB/Swiss-Prot
    Q0P6H9, Q6I9Y5, Q9H5J6
    UniProtKB/TrEMBL
    H3BVF7
    Related
    ENSP00000260403.2, ENST00000260403.7
    Conserved Domains (3) summary
    cd07401
    Location:57 → 345
    MPP_TMEM62_N; Homo sapiens TMEM62, N-terminal metallophosphatase domain
    pfam00149
    Location:59 → 259
    Metallophos; Calcineurin-like phosphoesterase
    pfam13754
    Location:351 → 409
    Big_3_4; Bacterial Ig-like domain (group 3)

RNA

  1. NR_144541.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068724

  2. NR_144542.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068724

  3. NR_144543.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068724

  4. NR_144544.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC068724

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    43133115..43185144
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047433103.1 → XP_047289059.1  transmembrane protein 62 isoform X3

  2. XM_047433101.1 → XP_047289057.1  transmembrane protein 62 isoform X1

  3. XM_047433102.1 → XP_047289058.1  transmembrane protein 62 isoform X2

  4. XM_024450071.2 → XP_024305839.1  transmembrane protein 62 isoform X6

    Conserved Domains (1) summary
    cl13995
    Location:92 → 126
    MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain

  5. XM_024450072.2 → XP_024305840.1  transmembrane protein 62 isoform X7

    Conserved Domains (1) summary
    cd07401
    Location:57 → 341
    MPP_TMEM62_N; Homo sapiens TMEM62, N-terminal metallophosphatase domain

  6. XM_047433104.1 → XP_047289060.1  transmembrane protein 62 isoform X4

  7. XM_047433105.1 → XP_047289061.1  transmembrane protein 62 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    40940411..40992433
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378895.1 → XP_054234870.1  transmembrane protein 62 isoform X3

  2. XM_054378898.1 → XP_054234873.1  transmembrane protein 62 isoform X6

  3. XM_054378899.1 → XP_054234874.1  transmembrane protein 62 isoform X7

  4. XM_054378896.1 → XP_054234871.1  transmembrane protein 62 isoform X4

  5. XM_054378897.1 → XP_054234872.1  transmembrane protein 62 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q0P6H9.1 GenPept UniProtKB/Swiss-Prot:Q0P6H9

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