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PRR5L proline rich 5 like [ Homo sapiens (human) ]

Gene ID: 79899, updated on 5-Mar-2024

Summary

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Official Symbol
PRR5Lprovided by HGNC
Official Full Name
proline rich 5 likeprovided by HGNC
Primary source
HGNC:HGNC:25878
See related
Ensembl:ENSG00000135362 MIM:611728; AllianceGenome:HGNC:25878
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PROTOR2
Summary
Enables ubiquitin protein ligase binding activity. Involved in several processes, including TORC2 signaling; positive regulation of mRNA catabolic process; and regulation of fibroblast migration. Part of TORC2 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen (RPKM 11.6), colon (RPKM 10.9) and 19 other tissues See more
Orthologs
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Genomic context

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Location:
11p13-p12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (36296288..36465204)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (36436630..36607651)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (36317838..36486754)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene low density lipoprotein receptor class A domain containing 3 Neighboring gene uncharacterized LOC101928510 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36111937-36112464 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36112465-36112991 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21313 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36127161-36128105 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36128106-36129049 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:36129695-36130220 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36130221-36130744 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36131269-36131792 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36132843-36133366 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36165205-36165812 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:36170828-36172027 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21355 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:36200889-36201107 Neighboring gene Sharpr-MPRA regulatory region 9208 Neighboring gene Sharpr-MPRA regulatory region 15199 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36310336-36311038 Neighboring gene COMM domain containing 9 Neighboring gene Sharpr-MPRA regulatory region 5372 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:36398745-36399316 Neighboring gene Sharpr-MPRA regulatory region 14138 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4632 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:36476801-36477325 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr11:36522348-36523547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4633 Neighboring gene TNF receptor associated factor 6 Neighboring gene recombination activating 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. PRAS40 and PRR5-like protein are new mTOR interactors that regulate apoptosis. Thedieck K, et al. PLoS One, 2007 Nov 21. PMID 18030348, Free PMC Article
  2. Protor-2 interacts with tristetraprolin to regulate mRNA stability during stress. Holmes B, et al. Cell Signal, 2012 Jan. PMID 21964062, Free PMC Article
  3. Hsp70 associates with Rictor and is required for mTORC2 formation and activity. Martin J, et al. Biochem Biophys Res Commun, 2008 Aug 8. PMID 18505677, Free PMC Article
  4. PRR5L degradation promotes mTORC2-mediated PKC-δ phosphorylation and cell migration downstream of Gα12. Gan X, et al. Nat Cell Biol, 2012 May 20. PMID 22609986, Free PMC Article
  5. Identification of Protor as a novel Rictor-binding component of mTOR complex-2. Pearce LR, et al. Biochem J, 2007 Aug 1. PMID 17461779, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14213, FLJ22630, MGC16218

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in TORC2 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in TORC2 signaling IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mRNA catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of fibroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of TORC2 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC2 complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
proline-rich protein 5-like
Names
Protein observed with Rictor-2
protor-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001160167.2 → NP_001153639.1  proline-rich protein 5-like isoform a

    See identical proteins and their annotated locations for NP_001153639.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC009656, AK055042, BX640959, DA344861, DA449593
    Consensus CDS
    CCDS31463.1
    UniProtKB/Swiss-Prot
    A4QN22, E9PKY1, Q6MZQ0, Q96H46, Q9H7V4
    UniProtKB/TrEMBL
    B3KNU3
    Related
    ENSP00000435050.1, ENST00000530639.6
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like

  2. NM_001160168.2 → NP_001153640.1  proline-rich protein 5-like isoform b

    See identical proteins and their annotated locations for NP_001153640.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at an alternate AUG and a shorter isoform (b) compared to isoform a.
    Source sequence(s)
    AC009656, AK024275, BX640959, DA458327
    UniProtKB/Swiss-Prot
    Q6MZQ0
    Related
    ENST00000389693.3
    Conserved Domains (1) summary
    pfam08539
    Location:5 → 100
    HbrB; HbrB-like

  3. NM_001160169.1 → NP_001153641.1  proline-rich protein 5-like isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 1. The encoded isoform (c) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AC009656, BC008922, BX640959, DA344861, DR001466
    Consensus CDS
    CCDS53617.1
    UniProtKB/Swiss-Prot
    Q6MZQ0
    Related
    ENSP00000435241.1, ENST00000527487.1
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like

  4. NM_024841.5 → NP_079117.3  proline-rich protein 5-like isoform a

    See identical proteins and their annotated locations for NP_079117.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same isoform (a).
    Source sequence(s)
    AC009656, BX640959, DA344861, DA458327
    Consensus CDS
    CCDS31463.1
    UniProtKB/Swiss-Prot
    A4QN22, E9PKY1, Q6MZQ0, Q96H46, Q9H7V4
    UniProtKB/TrEMBL
    B3KNU3
    Related
    ENSP00000368144.3, ENST00000378867.7
    Conserved Domains (1) summary
    pfam08539
    Location:49 → 168
    HbrB; HbrB-like

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    36296288..36465204
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    36436630..36607651
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6MZQ0.2 GenPept UniProtKB/Swiss-Prot:Q6MZQ0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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