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ZNF212 zinc finger protein 212 [ Homo sapiens (human) ]

Gene ID: 7988, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF212provided by HGNC
Official Full Name
zinc finger protein 212provided by HGNC
Primary source
HGNC:HGNC:13004
See related
Ensembl:ENSG00000170260 MIM:602386; AllianceGenome:HGNC:13004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF182; ZNFC150; C2H2-150
Summary
This gene belongs to the C2H2-type zinc finger gene family. The zinc finger proteins are involved in gene regulation and development, and are quite conserved throughout evolution. Like this gene product, a third of the zinc finger proteins containing C2H2 fingers also contain the KRAB domain, which has been found to be involved in protein-protein interactions. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in testis (RPKM 6.4), endometrium (RPKM 4.5) and 25 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7q36.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149239651..149255606)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150421475..150437430)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148936742..148952697)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 398 Neighboring gene centrosomal protein 83kDa pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148892414-148892735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148900065-148900565 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:148906433-148907147 Neighboring gene zinc finger protein 282 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148916930-148917919 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148923698-148923905 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:148930294-148931493 Neighboring gene Sharpr-MPRA regulatory region 80 Neighboring gene uncharacterized LOC124901769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18753 Neighboring gene zinc finger protein 783 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148978524-148979060 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18754 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148982524-148982701 Neighboring gene AI894139 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular cloning and mapping of a novel human KRAB domain-containing C2H2-type zinc finger to chromosome 7q36.1. Becker KG, et al. Genomics, 1997 May 1. PMID 9169157
  2. ZNF212 promotes genomic integrity through direct interaction with TRAIP. Chung HJ, et al. Nucleic Acids Res, 2023 Jan 25. PMID 36594163, Free PMC Article
  3. Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain. Becker KG, et al. Hum Mol Genet, 1995 Apr. PMID 7633419
  4. A protein-protein interaction network of transcription factors acting during liver cell proliferation. Gao J, et al. Genomics, 2008 Apr. PMID 18255255
  5. DULIP: A Dual Luminescence-Based Co-Immunoprecipitation Assay for Interactome Mapping in Mammalian Cells. Trepte P, et al. J Mol Biol, 2015 Oct 23. PMID 26264872

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF212 promotes genomic integrity through direct interaction with TRAIP.
    Title: ZNF212 promotes genomic integrity through direct interaction with TRAIP.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC9707

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in dendrite development IEA
Inferred from Electronic Annotation
more info
  
involved_in general adaptation syndrome, behavioral process IEA
Inferred from Electronic Annotation
more info
  
involved_in neuromuscular process controlling balance IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to alcohol IEA
Inferred from Electronic Annotation
more info
  
involved_in walking behavior IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
zinc finger protein 212
Names
Zinc finger protein C2H2-150

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012256.4 → NP_036388.2  zinc finger protein 212

    See identical proteins and their annotated locations for NP_036388.2

    Status: REVIEWED

    Source sequence(s)
    AK074821, BC022785
    Consensus CDS
    CCDS5896.1
    UniProtKB/Swiss-Prot
    B2RCF4, Q13396, Q8N664, Q9UDV6
    UniProtKB/TrEMBL
    A0A090N8N3, B3KQE6
    Related
    ENSP00000338572.2, ENST00000335870.7
    Conserved Domains (6) summary
    cd07765
    Location:142 → 180
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:367 → 479
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:371 → 391
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:318 → 338
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429 → 449
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:441 → 466
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    149239651..149255606
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    150421475..150437430
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UDV6.3 GenPept UniProtKB/Swiss-Prot:Q9UDV6

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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