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ZBTB3 zinc finger and BTB domain containing 3 [ Homo sapiens (human) ]

Gene ID: 79842, updated on 5-Mar-2024

Summary

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Official Symbol
ZBTB3provided by HGNC
Official Full Name
zinc finger and BTB domain containing 3provided by HGNC
Primary source
HGNC:HGNC:22918
See related
Ensembl:ENSG00000185670 AllianceGenome:HGNC:22918
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 1.5), skin (RPKM 1.4) and 25 other tissues See more
Orthologs
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Genomic context

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See ZBTB3 in Genome Data Viewer
Location:
11q12.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (62750963..62754160, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (62740349..62743546, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (62518435..62521632, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene HNRNPUL2-BSCL2 readthrough (NMD candidate) Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:62482895-62483396 Neighboring gene heterogeneous nuclear ribonucleoprotein U like 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3428 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4841 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4842 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4843 Neighboring gene tetratricopeptide repeat domain 9C Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62520285-62521162 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62522043-62522920 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:62524299-62524825 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4844 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4845 Neighboring gene RNA polymerase II subunit G Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3429 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4847 Neighboring gene transmembrane protein 223 Neighboring gene TATA-box binding protein associated factor 6 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 4848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3430

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells. Lim JH. BMB Rep, 2014 Jul. PMID 24856827, Free PMC Article
  2. An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping. Wang Z, et al. Nat Commun, 2023 Mar 3. PMID 36869052, Free PMC Article
  3. E3 ubiquitin ligase RBX1 drives the metastasis of triple negative breast cancer through a FBXO45-TWIST1-dependent degradation mechanism. Shao J, et al. Aging (Albany NY), 2022 Jul 8. PMID 35802537, Free PMC Article
  4. SPOP targets oncogenic protein ZBTB3 for destruction to suppress endometrial cancer. Jin X, et al. Am J Cancer Res, 2019. PMID 31911863, Free PMC Article
  5. Recruitment of the Mammalian Histone-modifying EMSY Complex to Target Genes Is Regulated by ZNF131. Varier RA, et al. J Biol Chem, 2016 Apr 1. PMID 26841866, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping.
    Title: An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping.
  2. Suppression of ZBTB3 activates a caspase cascade, including caspase-9, -3, and PARP leading to cellular apoptosis, resulting from failed ROS detoxification.
    Title: Zinc finger and BTB domain-containing protein 3 is essential for the growth of cancer cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23392

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger and BTB domain-containing protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363108.2 → NP_001350037.1  zinc finger and BTB domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Consensus CDS
    CCDS8034.2
    UniProtKB/Swiss-Prot
    Q9H5J0
    UniProtKB/TrEMBL
    A0A6E1W9L1
    Conserved Domains (4) summary
    PHA03247
    Location:173 → 401
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:424 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18323
    Location:1 → 130
    BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)
    pfam13465
    Location:437 → 461
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001363109.2 → NP_001350038.1  zinc finger and BTB domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Consensus CDS
    CCDS8034.2
    UniProtKB/Swiss-Prot
    Q9H5J0
    UniProtKB/TrEMBL
    A0A6E1W9L1
    Conserved Domains (4) summary
    PHA03247
    Location:173 → 401
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:424 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18323
    Location:1 → 130
    BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)
    pfam13465
    Location:437 → 461
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001370809.1 → NP_001357738.1  zinc finger and BTB domain-containing protein 3

    Status: VALIDATED

    Source sequence(s)
    AP001160
    Consensus CDS
    CCDS8034.2
    UniProtKB/Swiss-Prot
    Q9H5J0
    UniProtKB/TrEMBL
    A0A6E1W9L1
    Related
    ENSP00000378286.4, ENST00000394807.5
    Conserved Domains (4) summary
    PHA03247
    Location:173 → 401
    PHA03247; large tegument protein UL36; Provisional
    sd00017
    Location:424 → 444
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd18323
    Location:1 → 130
    BTB_POZ_ZBTB3; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 3 (ZBTB3)
    pfam13465
    Location:437 → 461
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    62750963..62754160 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    62740349..62743546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_024784.4: Suppressed sequence

    Description
    NM_024784.4: This RefSeq was removed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H5J0.1 GenPept UniProtKB/Swiss-Prot:Q9H5J0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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