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ZNF552 zinc finger protein 552 [ Homo sapiens (human) ]

Gene ID: 79818, updated on 7-Apr-2024

Summary

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Official Symbol
ZNF552provided by HGNC
Official Full Name
zinc finger protein 552provided by HGNC
Primary source
HGNC:HGNC:26135
See related
Ensembl:ENSG00000178935 AllianceGenome:HGNC:26135
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in urinary bladder (RPKM 8.2), prostate (RPKM 4.1) and 24 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.43
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (57807082..57814913, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (60904000..60915346, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (58318450..58326281, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15157 Neighboring gene zinc finger protein 776 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58280768-58281307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15159 Neighboring gene zinc finger protein 586 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58297126-58297745 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58297746-58298364 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:58300764-58300910 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:58309809-58310356 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15160 Neighboring gene Sharpr-MPRA regulatory region 649 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58314953-58315566 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:58322897-58323548 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:58333533-58334033 Neighboring gene FKBP prolyl isomerase 1A pseudogene 1 Neighboring gene zinc finger protein 587B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF552, a novel human KRAB/C2H2 zinc finger protein, inhibits AP-1- and SRE-mediated transcriptional activity. Deng Y, et al. BMB Rep, 2010 Mar. PMID 20356460
  2. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. Nozawa RS, et al. Nat Cell Biol, 2010 Jul. PMID 20562864
  3. Oncogenic functions of protein kinase D2 and D3 in regulating multiple cancer-related pathways in breast cancer. Liu Y, et al. Cancer Med, 2019 Feb. PMID 30652415, Free PMC Article
  4. Genome-scale RNAi screen for host factors required for HIV replication. Zhou H, et al. Cell Host Microbe, 2008 Nov 13. PMID 18976975
  5. Combinatorial targeting of a chromatin complex comprising Dot1L, menin and the tyrosine kinase BAZ1B reveals a new therapeutic vulnerability of endocrine therapy-resistant breast cancer. Salvati A, et al. Breast Cancer Res, 2022 Jul 18. PMID 35850772, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 552 (ZNF552) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ21603

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 552

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024762.3 → NP_079038.2  zinc finger protein 552

    See identical proteins and their annotated locations for NP_079038.2

    Status: VALIDATED

    Source sequence(s)
    AC010645, DA345819
    Consensus CDS
    CCDS12963.1
    UniProtKB/Swiss-Prot
    B3KUE9, Q6P5A6, Q9H707
    Related
    ENSP00000375582.1, ENST00000391701.1
    Conserved Domains (5) summary
    smart00349
    Location:14 → 55
    KRAB; krueppel associated box
    COG5048
    Location:243 → 407
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:298 → 318
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:339 → 362
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    57807082..57814913 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259267.5 → XP_005259324.1  zinc finger protein 552 isoform X1

    See identical proteins and their annotated locations for XP_005259324.1

    UniProtKB/TrEMBL
    B7Z1H1
    Conserved Domains (5) summary
    smart00349
    Location:10 → 51
    KRAB; krueppel associated box
    COG5048
    Location:215 → 403
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:294 → 314
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:10 → 49
    KRAB; KRAB box
    pfam13465
    Location:335 → 358
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    60904000..60915346 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322191.1 → XP_054178166.1  zinc finger protein 552 isoform X1

    UniProtKB/TrEMBL
    B7Z1H1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H707.2 GenPept UniProtKB/Swiss-Prot:Q9H707

Gene LinkOut

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