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SHCBP1 SHC binding and spindle associated 1 [ Homo sapiens (human) ]

Gene ID: 79801, updated on 5-Mar-2024

Summary

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Official Symbol
SHCBP1provided by HGNC
Official Full Name
SHC binding and spindle associated 1provided by HGNC
Primary source
HGNC:HGNC:29547
See related
Ensembl:ENSG00000171241 MIM:611027; AllianceGenome:HGNC:29547
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAL
Summary
Predicted to enable SH2 domain binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway and regulation of neural precursor cell proliferation. Predicted to be located in cytoplasm; midbody; and spindle. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 5.2), lymph node (RPKM 5.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
16q11.2
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (46578591..46621379, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (52375421..52418229, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (46612503..46655291, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:46607141-46607791 Neighboring gene zinc finger and BTB domain containing 14 pseudogene Neighboring gene RAB31, member RAS oncogene family pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10770 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:46654434-46655022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:46655023-46655609 Neighboring gene RAB43 pseudogene 1 Neighboring gene VPS35 retromer complex component Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7430 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:46722561-46723258

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Biological functions and therapeutic potential of SHCBP1 in human cancer. Lin Y, et al. Biomed Pharmacother, 2023 Apr. PMID 36739763
  2. SHCBP1 Is a Prognostic Biomarker Related to the Tumour Immune Microenvironment in Pan-Cancer. Huang Y, et al. Ann Clin Lab Sci, 2022 Nov. PMID 36564070
  3. SHCBP1 Promotes the Progression of Esophageal Squamous Cell Carcinoma Via the TGFβ Pathway. Ren C, et al. Appl Immunohistochem Mol Morphol, 2021 Feb 1. PMID 32769441, Free PMC Article
  4. SHCBP1 promotes tumor cell proliferation, migration, and invasion, and is associated with poor prostate cancer prognosis. Xu N, et al. J Cancer Res Clin Oncol, 2020 Aug. PMID 32447485
  5. SHCBP1 promotes cisplatin induced apoptosis resistance, migration and invasion through activating Wnt pathway. Zou A, et al. Life Sci, 2019 Oct 15. PMID 31472149

See all (64) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The dynamic role of nucleoprotein SHCBP1 in the cancer cell cycle and its potential as a synergistic target for DNA-damaging agents in cancer therapy.
    Title: The dynamic role of nucleoprotein SHCBP1 in the cancer cell cycle and its potential as a synergistic target for DNA-damaging agents in cancer therapy.
  2. Biological functions and therapeutic potential of SHCBP1 in human cancer.
    Title: Biological functions and therapeutic potential of SHCBP1 in human cancer.
  3. SHCBP1 Is a Prognostic Biomarker Related to the Tumour Immune Microenvironment in Pan-Cancer.
    Title: SHCBP1 Is a Prognostic Biomarker Related to the Tumour Immune Microenvironment in Pan-Cancer.
  4. EGF-induced nuclear translocation of SHCBP1 promotes bladder cancer progression through inhibiting RACGAP1-mediated RAC1 inactivation.
    Title: EGF-induced nuclear translocation of SHCBP1 promotes bladder cancer progression through inhibiting RACGAP1-mediated RAC1 inactivation.
  5. SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.
    Title: SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer.
  6. Long Non-Coding RNA TP53TG1 Upregulates SHCBP1 to Promote Retinoblastoma Progression by Sponging miR-33b.
    Title: Long Non-Coding RNA TP53TG1 Upregulates SHCBP1 to Promote Retinoblastoma Progression by Sponging miR-33b.
  7. SHCBP1 Promotes the Progression of Esophageal Squamous Cell Carcinoma Via the TGFbeta Pathway.
    Title: SHCBP1 Promotes the Progression of Esophageal Squamous Cell Carcinoma Via the TGFβ Pathway.
  8. Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer.
    Title: Hyperactivation of HER2-SHCBP1-PLK1 axis promotes tumor cell mitosis and impairs trastuzumab sensitivity to gastric cancer.
  9. SOX2-induced upregulation of lncRNA LINC01561 promotes non-small-cell lung carcinoma progression by sponging miR-760 to modulate SHCBP1 expression.
    Title: SOX2-induced upregulation of lncRNA LINC01561 promotes non-small-cell lung carcinoma progression by sponging miR-760 to modulate SHCBP1 expression.
  10. PART1 and hsa-miR-429-Mediated SHCBP1 Expression Is an Independent Predictor of Poor Prognosis in Glioma Patients.
    Title: PART1 and hsa-miR-429-Mediated SHCBP1 Expression Is an Independent Predictor of Poor Prognosis in Glioma Patients.
Submit: New GeneRIF Correction See all GeneRIFs (22)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of SHC SH2-domain binding protein 1 (SHCBP1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ22009, MGC26900

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH2 domain binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in fibroblast growth factor receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fibroblast growth factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of neural precursor cell proliferation ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in midbody IEA
Inferred from Electronic Annotation
more info
  
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SHC SH2 domain-binding protein 1
Names
Protein expressed in Activated Lymphocytes

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324318.2 → NP_001311247.1  SHC SH2 domain-binding protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC092368
    UniProtKB/TrEMBL
    A8K7Z9, B2RDX0

  2. NM_001324319.2 → NP_001311248.1  SHC SH2 domain-binding protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC092368
    UniProtKB/TrEMBL
    A8K7Z9, B2RDX0

  3. NM_024745.5 → NP_079021.4  SHC SH2 domain-binding protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC092368
    Consensus CDS
    CCDS10720.1
    UniProtKB/Swiss-Prot
    Q8NEM2, Q96N60, Q9BVS0, Q9H6P6
    UniProtKB/TrEMBL
    A8K7Z9, B2RDX0
    Related
    ENSP00000306473.3, ENST00000303383.8
    Conserved Domains (1) summary
    pfam13229
    Location:446 → 547
    Beta_helix; Right handed beta helix region

RNA

  1. NR_136738.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092368

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    46578591..46621379 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047434653.1 → XP_047290609.1  SHC SH2 domain-binding protein 1 isoform X1

  2. XM_011523335.4 → XP_011521637.1  SHC SH2 domain-binding protein 1 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    52375421..52418229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054313950.1 → XP_054169925.1  SHC SH2 domain-binding protein 1 isoform X1

  2. XM_054313951.1 → XP_054169926.1  SHC SH2 domain-binding protein 1 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NEM2.3 GenPept UniProtKB/Swiss-Prot:Q8NEM2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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