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ZFAND1 zinc finger AN1-type containing 1 [ Homo sapiens (human) ]

Gene ID: 79752, updated on 5-Mar-2024

Summary

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Official Symbol
ZFAND1provided by HGNC
Official Full Name
zinc finger AN1-type containing 1provided by HGNC
Primary source
HGNC:HGNC:25858
See related
Ensembl:ENSG00000104231 AllianceGenome:HGNC:25858
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables proteasome binding activity. Involved in cellular response to arsenite ion; positive regulation of intracellular protein transport; and stress granule disassembly. Located in cytoplasmic stress granule. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 23.7), ovary (RPKM 15.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
8q21.13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (81701331..81721304, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (82133043..82153000, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (82613566..82633539, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene inositol monophosphatase 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:82598306-82598806 Neighboring gene solute carrier family 10 member 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:82632569-82633513 Neighboring gene charged multivesicular body protein 4C Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:82695196-82696395 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 36 Neighboring gene sorting nexin 16

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner. Gwon Y, et al. Science, 2021 Jun 25. PMID 34739333, Free PMC Article
  2. ZFAND1 Recruits p97 and the 26S Proteasome to Promote the Clearance of Arsenite-Induced Stress Granules. Turakhiya A, et al. Mol Cell, 2018 Jun 7. PMID 29804830
  3. GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer. Pharoah PD, et al. Nat Genet, 2013 Apr. PMID 23535730, Free PMC Article
  4. A conserved protein with AN1 zinc finger and ubiquitin-like domains modulates Cdc48 (p97) function in the ubiquitin-proteasome pathway. Sá-Moura B, et al. J Biol Chem, 2013 Nov 22. PMID 24121501, Free PMC Article
  5. Targeting RICTOR Sensitizes SMAD4-Negative Colon Cancer to Irinotecan. Wong CK, et al. Mol Cancer Res, 2020 Mar. PMID 31932471, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14007

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables proteasome binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to arsenite ion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in cellular response to heat IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in cellular response to osmotic stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
NOT involved_in cellular response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of intracellular protein transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in stress granule disassembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in stress granule disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AN1-type zinc finger protein 1
Names
zinc finger AN1-type-containing protein 1
zinc finger, AN1-type domain 1
NP_001164267.1
NP_001164268.1
NP_078975.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170796.1 → NP_001164267.1  AN1-type zinc finger protein 1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in an isoform (b) that is shorter than isoform a.
    Source sequence(s)
    AC132219, AK225195, BQ427843, BU678501
    Consensus CDS
    CCDS55251.1
    UniProtKB/Swiss-Prot
    Q8TCF1
    Related
    ENSP00000430736.1, ENST00000523096.5
    Conserved Domains (1) summary
    pfam01428
    Location:10 → 46
    zf-AN1; AN1-like Zinc finger

  2. NM_001170797.2 → NP_001164268.1  AN1-type zinc finger protein 1 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 3' coding region and 3' UTR, compared to variant 1, resulting in an isoform (c) with a distinct and shorter C-terminus, compared to isoform a.
    Source sequence(s)
    BQ427843, CA412820
    Consensus CDS
    CCDS55250.1
    UniProtKB/Swiss-Prot
    Q8TCF1
    Related
    ENSP00000429167.1, ENST00000519523.5
    Conserved Domains (1) summary
    pfam01428
    Location:10 → 46
    zf-AN1; AN1-like Zinc finger

  3. NM_024699.3 → NP_078975.2  AN1-type zinc finger protein 1 isoform a

    See identical proteins and their annotated locations for NP_078975.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AC132219, BC022251, BQ427843, BU678501
    Consensus CDS
    CCDS6232.1
    UniProtKB/Swiss-Prot
    E5RIG0, E5RJ99, Q658R7, Q6IA32, Q6PGQ6, Q8TCF1, Q9H810
    Related
    ENSP00000220669.5, ENST00000220669.10
    Conserved Domains (1) summary
    pfam01428
    Location:10 → 46
    zf-AN1; AN1-like Zinc finger

RNA

  1. NR_033193.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate internal exon but includes a different alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of upstream ORFs that are predicted to interfere with the translation of the longest ORF; translation from an upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132219, BG618233, BQ427843, BU678501

  2. NR_033194.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of upstream ORFs that are predicted to interfere with the translation of the longest ORF; translation from an upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132219, BC051857, BQ427843, BU678501

  3. NR_033195.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in the 5' exon and lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding due to the presence of upstream ORFs that are predicted to interfere with the translation of the longest ORF; translation from an upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132219, BQ427843, BQ435400, BU678501

  4. NR_033196.2 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) lacks an alternate internal exon and differs in its 3'-most exon, compared to variant 1. This variant is represented as non-coding due to the presence of upstream ORFs that are predicted to interfere with the translation of the longest ORF; translation from an upstream ORF makes the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC132219, BQ427843, BU624414
    Related
    ENST00000517588.5

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    81701331..81721304 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    82133043..82153000 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8TCF1.1 GenPept UniProtKB/Swiss-Prot:Q8TCF1

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