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VPS37B VPS37B subunit of ESCRT-I [ Homo sapiens (human) ]

Gene ID: 79720, updated on 10-Dec-2024

Summary

Official Symbol
VPS37Bprovided by HGNC
Official Full Name
VPS37B subunit of ESCRT-Iprovided by HGNC
Primary source
HGNC:HGNC:25754
See related
Ensembl:ENSG00000139722 MIM:610037; AllianceGenome:HGNC:25754
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables calcium-dependent protein binding activity. Predicted to be involved in protein targeting to membrane; protein targeting to vacuole; and ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway. Located in endosome membrane; midbody; and plasma membrane. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Ubiquitous expression in esophagus (RPKM 9.2), colon (RPKM 9.0) and 25 other tissues See more
Orthologs
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Genomic context

See VPS37B in Genome Data Viewer
Location:
12q24.31
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (122865330..122896124, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (122860577..122891354, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (123349877..123380671, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5021 Neighboring gene Sharpr-MPRA regulatory region 13845 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:123274450-123275003 Neighboring gene coiled-coil domain containing 62 Neighboring gene MPRA-validated peak2023 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr12:123296784-123296959 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7238 Neighboring gene MPRA-validated peak2024 silencer Neighboring gene uncharacterized LOC124903040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7239 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5022 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5023 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:123329929-123330760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:123338415-123338915 Neighboring gene huntingtin interacting protein 1 related Neighboring gene Sharpr-MPRA regulatory region 11411 Neighboring gene uncharacterized LOC124903039 Neighboring gene hESC enhancers GRCh37_chr12:123356243-123356750 and GRCh37_chr12:123356751-123357257 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:123357767-123358273 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7241 Neighboring gene ReSE screen-validated silencer GRCh37_chr12:123361289-123361497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7243 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:123372974-123373690 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:123375921-123376422 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr12:123376423-123376922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7244 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5024 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:123394282-123394782 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr12:123394783-123395283 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:123407378-123407878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:123407879-123408379 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:123414465-123414965 Neighboring gene ATP binding cassette subfamily B member 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:123424202-123425057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:123429718-123430527 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:123431158-123431906 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:123449651-123450458 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:123450459-123451264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7247 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7248 Neighboring gene H3K27ac hESC enhancers GRCh37_chr12:123464801-123465306 and GRCh37_chr12:123465307-123465812 Neighboring gene 2-oxoglutarate and iron dependent oxygenase domain containing 2 Neighboring gene ARF like GTPase 6 interacting protein 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Tsg 101, VPS 28, and VPS 37B form the human endosomal sorting complex required for transport (ESCRT-I), which is required for HIV-1 Gag budding and virus infectivity PubMed
nucleocapsid gag GST-fused NCp6 fragment binds ESCRT-I subunits such as MVB12B, VPS37B, VPS28, and TSG101 PubMed
gag ESCRT-I complexes contain three common subunits (TSG101, VPS28, and VPS37), and a fourth subunit MVB12. Recombinant ESCRT-I complexes bind HIV-1 p6 PubMed
p6 gag GST-fused NCp6 fragment binds ESCRT-I subunits such as MVB12B, VPS37B, VPS28, and TSG101 PubMed
gag ESCRT-I complexes contain three common subunits (TSG101, VPS28, and VPS37), and a fourth subunit MVB12. Recombinant ESCRT-I complexes bind HIV-1 p6 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ12750

Gene Ontology Provided by GOA

Component Evidence Code Pubs
part_of ESCRT I complex  
part_of ESCRT I complex PubMed 
part_of ESCRT I complex PubMed 
part_of ESCRT I complex PubMed 
located_in cytoplasm PubMed 
located_in endosome PubMed 
located_in endosome membrane PubMed 
located_in endosome membrane PubMed 
located_in endosome membrane  
located_in extracellular exosome PubMed 
located_in late endosome membrane  
located_in midbody PubMed 
located_in plasma membrane PubMed 

General protein information

Preferred Names
vacuolar protein sorting-associated protein 37B
Names
ESCRT-I complex subunit VPS37B
VPS37B, ESCRT-I subunit
hVps37B
vacuolar protein sorting 37 homolog B
vacuolar protein sorting 37B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024667.3NP_078943.1  vacuolar protein sorting-associated protein 37B

    See identical proteins and their annotated locations for NP_078943.1

    Status: VALIDATED

    Source sequence(s)
    AK022812, BU629695
    Consensus CDS
    CCDS9239.1
    UniProtKB/Swiss-Prot
    Q9H9H4
    UniProtKB/TrEMBL
    F5H4M0
    Related
    ENSP00000267202.2, ENST00000267202.7
    Conserved Domains (1) summary
    pfam07200
    Location:11156
    Mod_r; Modifier of rudimentary (Mod(r)) protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    122865330..122896124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538743.3XP_011537045.1  vacuolar protein sorting-associated protein 37B isoform X1

    Conserved Domains (1) summary
    pfam07200
    Location:96211
    Mod_r; Modifier of rudimentary (Mod(r)) protein
  2. XM_011538745.3XP_011537047.1  vacuolar protein sorting-associated protein 37B isoform X2

    UniProtKB/TrEMBL
    F5H4M0
    Conserved Domains (1) summary
    pfam07200
    Location:20134
    Mod_r; Modifier of rudimentary (Mod(r)) protein
  3. XM_047429550.1XP_047285506.1  vacuolar protein sorting-associated protein 37B isoform X3

    UniProtKB/TrEMBL
    F5H4M0
  4. XM_006719602.5XP_006719665.1  vacuolar protein sorting-associated protein 37B isoform X3

    See identical proteins and their annotated locations for XP_006719665.1

    UniProtKB/TrEMBL
    F5H4M0
    Conserved Domains (1) summary
    pfam07200
    Location:10124
    Mod_r; Modifier of rudimentary (Mod(r)) protein
  5. XM_017019971.2XP_016875460.1  vacuolar protein sorting-associated protein 37B isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    122860577..122891354 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373237.1XP_054229212.1  vacuolar protein sorting-associated protein 37B isoform X1

  2. XM_054373238.1XP_054229213.1  vacuolar protein sorting-associated protein 37B isoform X2

    UniProtKB/TrEMBL
    F5H4M0
  3. XM_054373239.1XP_054229214.1  vacuolar protein sorting-associated protein 37B isoform X3

    UniProtKB/TrEMBL
    F5H4M0
  4. XM_054373240.1XP_054229215.1  vacuolar protein sorting-associated protein 37B isoform X3

    UniProtKB/TrEMBL
    F5H4M0
  5. XM_054373241.1XP_054229216.1  vacuolar protein sorting-associated protein 37B isoform X3

    UniProtKB/TrEMBL
    F5H4M0
  6. XM_054373242.1XP_054229217.1  vacuolar protein sorting-associated protein 37B isoform X4

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