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STEAP4 STEAP4 metalloreductase [ Homo sapiens (human) ]

Gene ID: 79689, updated on 11-Apr-2024

Summary

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Official Symbol
STEAP4provided by HGNC
Official Full Name
STEAP4 metalloreductaseprovided by HGNC
Primary source
HGNC:HGNC:21923
See related
Ensembl:ENSG00000127954 MIM:611098; AllianceGenome:HGNC:21923
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIARP; STAMP2; SchLAH; TNFAIP9
Summary
The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
Expression
Broad expression in fat (RPKM 50.0), prostate (RPKM 32.8) and 17 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
7q21.12
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (88270892..88306894, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (89521348..89557349, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (87900207..87936209, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901691 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18355 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18356 Neighboring gene Sharpr-MPRA regulatory region 10982 Neighboring gene SRI antisense RNA 1 Neighboring gene sorcin Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:87894735-87895298 Neighboring gene uncharacterized LOC124901692 Neighboring gene uncharacterized LOC107986815 Neighboring gene eukaryotic translation initiation factor 4A1 pseudogene 13

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STEAP4 promoter methylation correlates with tumorigenesis of hepatocellular carcinoma. Tang Y, et al. Pathol Res Pract, 2022 May. PMID 35390632
  2. Cilostazol Improves HFD-Induced Hepatic Steatosis by Upregulating Hepatic STAMP2 Expression through AMPK. Oh YJ, et al. Mol Pharmacol, 2018 Dec. PMID 30366981
  3. Clinical and functional significance of STEAP4-splice variant in CD14(+) monocytes in patients with rheumatoid arthritis. Ebe H, et al. Clin Exp Immunol, 2018 Mar. PMID 29080328, Free PMC Article
  4. STEAP4: its emerging role in metabolism and homeostasis of cellular iron and copper. Scarl RT, et al. J Endocrinol, 2017 Sep. PMID 28576871, Free PMC Article
  5. STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation. Gordon HM, et al. Endocrine, 2017 Jun. PMID 28405880, Free PMC Article

See all (53) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia.
    Title: STEAP4 modulates cell proliferation and oxidative stress in benign prostatic hyperplasia.
  2. STEAP4 promoter methylation correlates with tumorigenesis of hepatocellular carcinoma.
    Title: STEAP4 promoter methylation correlates with tumorigenesis of hepatocellular carcinoma.
  3. sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
    Title: sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes.
  4. Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.
    Title: Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.
  5. Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation.
    Title: Stamp2 Protects From Maladaptive Structural Remodeling and Systolic Dysfunction in Post-Ischemic Hearts by Attenuating Neutrophil Activation.
  6. The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice.
    Title: The six-transmembrane protein Stamp2 ameliorates pulmonary vascular remodeling and pulmonary hypertension in mice.
  7. The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.
    Title: The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.
  8. Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease.
    Title: Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease.
  9. Enhancing STAMP2 expression with cilostazol represents a potential therapeutic avenue for treatment of NAFLD.
    Title: Cilostazol Improves HFD-Induced Hepatic Steatosis by Upregulating Hepatic STAMP2 Expression through AMPK.
  10. this study identified specific up-regulation of spliced variant STEAP4 in rheumatoid arthritis monocytes. This variant of STEAP4 might play a crucial role in the production of TNF-alpha and IL-6 through NF-kappaB and STAT-3 pathways, resulting in the generation of rheumatoid arthritis
    Title: Clinical and functional significance of STEAP4-splice variant in CD14(+) monocytes in patients with rheumatoid arthritis.
Submit: New GeneRIF Correction See all GeneRIFs (41)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of STEAP family member 4 (STEAP4; TNFAIP9) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23153, DKFZp666D049

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables FAD binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables cupric reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferric-chelate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ferric-chelate reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables heme binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fat cell differentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in iron import into cell IEA
Inferred from Electronic Annotation
more info
  
involved_in protein homotrimerization IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in early endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular exosome HDA PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
metalloreductase STEAP4
Names
STEAP family member 4
seven chromosome locus associated with HCC
six transmembrane prostate protein 2
six-transmembrane epithelial antigen of prostate 4
sixTransMembrane protein of prostate 2
tumor necrosis factor, alpha-induced protein 9
tumor necrosis-alpha-induced adipose-related protein
NP_001192244.1
NP_001192245.1
NP_078912.2

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028313.2 RefSeqGene

    Range
    5000..41002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001205315.2 → NP_001192244.1  metalloreductase STEAP4 isoform 1

    See identical proteins and their annotated locations for NP_001192244.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an additional 5' non-coding exon, and has a longer 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AC003991, AF423422, AL833671, DB162772, DC333286
    Consensus CDS
    CCDS43611.1
    UniProtKB/Swiss-Prot
    Q658Q9, Q687X4, Q687X5, Q8WWB0, Q9H5R1
    Conserved Domains (2) summary
    COG2085
    Location:21 → 201
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:251 → 393
    Ferric_reduct; Ferric reductase like transmembrane component

  2. NM_001205316.2 → NP_001192245.1  metalloreductase STEAP4 isoform 2

    See identical proteins and their annotated locations for NP_001192245.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame coding exon compared to variant 1, resulting in a shorter isoform (2) missing an internal protein segment compared to isoform 1.
    Source sequence(s)
    AC003991, AK307644, AL833671, BC020600, DC333286
    Consensus CDS
    CCDS56494.1
    UniProtKB/Swiss-Prot
    Q687X5
    Related
    ENSP00000305545.5, ENST00000301959.9
    Conserved Domains (2) summary
    COG2085
    Location:21 → 155
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:163 → 217
    Ferric_reduct; Ferric reductase like transmembrane component

  3. NM_024636.4 → NP_078912.2  metalloreductase STEAP4 isoform 1

    See identical proteins and their annotated locations for NP_078912.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript, and encodes the longer isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AC003991, AF423422, AK307644, AL833671, DC333286
    Consensus CDS
    CCDS43611.1
    UniProtKB/Swiss-Prot
    Q658Q9, Q687X4, Q687X5, Q8WWB0, Q9H5R1
    Related
    ENSP00000369419.4, ENST00000380079.9
    Conserved Domains (2) summary
    COG2085
    Location:21 → 201
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:251 → 393
    Ferric_reduct; Ferric reductase like transmembrane component

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    88270892..88306894 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    89521348..89557349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q687X5.1 GenPept UniProtKB/Swiss-Prot:Q687X5

Gene LinkOut

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