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ZDHHC14 zinc finger DHHC-type palmitoyltransferase 14 [ Homo sapiens (human) ]

Gene ID: 79683, updated on 5-Mar-2024

Summary

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Official Symbol
ZDHHC14provided by HGNC
Official Full Name
zinc finger DHHC-type palmitoyltransferase 14provided by HGNC
Primary source
HGNC:HGNC:20341
See related
Ensembl:ENSG00000175048 MIM:619295; AllianceGenome:HGNC:20341
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NEW1CP
Summary
Enables palmitoyltransferase activity. Involved in peptidyl-L-cysteine S-palmitoylation. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in brain (RPKM 2.5), endometrium (RPKM 2.3) and 24 other tissues See more
Orthologs
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Genomic context

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See ZDHHC14 in Genome Data Viewer
Location:
6q25.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (157381190..157678157)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (158623184..158923532)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (157802222..158099189)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene chromosome 18 open reading frame 21 pseudogene Neighboring gene uncharacterized LOC124901446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157800546-157801158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17723 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:157801770-157802381 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17725 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25331 Neighboring gene H3K4me1 hESC enhancers GRCh37_chr6:157818864-157819364 and GRCh37_chr6:157819365-157819865 Neighboring gene MPRA-validated peak6255 silencer Neighboring gene MPRA-validated peak6257 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:157867979-157868480 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:157868882-157869106 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157876133-157877024 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157885378-157885878 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157885879-157886379 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157887214-157888001 Neighboring gene MPRA-validated peak6259 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157938365-157938888 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157938889-157939410 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157951781-157952686 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157952687-157953591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157954158-157954658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:157954659-157955159 Neighboring gene MPRA-validated peak6260 silencer Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157973253-157974075 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157977751-157978536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25334 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157982847-157983820 Neighboring gene microRNA 3692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:157993864-157994596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158014227-158014728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158014729-158015228 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158037061-158037562 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158037563-158038062 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158066653-158067153 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:158069048-158070247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158090399-158091006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158091007-158091612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158109923-158110424 Neighboring gene uncharacterized LOC107986663 Neighboring gene NANOG hESC enhancer GRCh37_chr6:158127150-158127715 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:158131630-158132829 Neighboring gene uncharacterized LOC124901555 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158134197-158134698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158134699-158135198 Neighboring gene NANOG hESC enhancer GRCh37_chr6:158152966-158153487 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:158153745-158154270 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:158162257-158162797 Neighboring gene Sharpr-MPRA regulatory region 4686 Neighboring gene Sharpr-MPRA regulatory region 7014 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr6:158183852-158185051 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25338 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17727 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25339 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:158251124-158251862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25340 Neighboring gene Sharpr-MPRA regulatory region 12251 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25341 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17728 Neighboring gene sorting nexin 9 Neighboring gene SNX9 antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer. Oo HZ, et al. Oncol Rep, 2014 Jul. PMID 24807047
  2. Identification of ZDHHC14 as a novel human tumour suppressor gene. Yeste-Velasco M, et al. J Pathol, 2014 Apr. PMID 24407904
  3. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment. Sanders SS, et al. Elife, 2020 Nov 13. PMID 33185190, Free PMC Article
  4. S-Palmitoylation of a Novel Site in the β2-Adrenergic Receptor Associated with a Novel Intracellular Itinerary. Adachi N, et al. J Biol Chem, 2016 Sep 16. PMID 27481942, Free PMC Article
  5. Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D. Clark SL, et al. Psychol Med, 2012 Jun. PMID 22041458, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
    Title: The palmitoyl acyltransferase ZDHHC14 controls Kv1-family potassium channel clustering at the axon initial segment.
  2. Results indicate that ZDHHC14 is involved in tumor progression in patients with scirrhous type gastric cancer.
    Title: Overexpression of ZDHHC14 promotes migration and invasion of scirrhous type gastric cancer.
  3. Identify ZDHHC14 as a novel tumour suppressor gene that is commonly down-regulated in testicular germ cell tumours and prostate cancer.
    Title: Identification of ZDHHC14 as a novel human tumour suppressor gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Pharmacogenomic study of side-effects for antidepressant treatment options in STAR*D.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20984

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables palmitoyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity IC
Inferred by Curator
more info
 PubMed 
Process Evidence Code Pubs
involved_in peptidyl-L-cysteine S-palmitoylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-L-cysteine S-palmitoylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein palmitoylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
palmitoyltransferase ZDHHC14
Names
DHHC domain-containing cysteine-rich protein 14
DHHC-14
NEW1 domain-containing protein
probable palmitoyltransferase ZDHHC14
zinc finger DHHC domain-containing protein 14
zinc finger DHHC-type containing 14
zinc finger, DHHC domain containing 14
NP_078906.2
NP_714968.1
XP_016866797.1
XP_016866798.1
XP_016866799.1
XP_047275322.1
XP_047275324.1
XP_054212412.1
XP_054212413.1
XP_054212414.1
XP_054212415.1
XP_054212416.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024630.3 → NP_078906.2  palmitoyltransferase ZDHHC14 isoform 1

    See identical proteins and their annotated locations for NP_078906.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF542388, AL117344, AL133510
    Consensus CDS
    CCDS5252.1
    UniProtKB/Swiss-Prot
    A6NDB7, Q5JS07, Q5JS08, Q6PHS4, Q8IZN2, Q8IZN3, Q9H7F1
    UniProtKB/TrEMBL
    A4FVA9
    Related
    ENSP00000352821.5, ENST00000359775.10
    Conserved Domains (2) summary
    PHA03247
    Location:314 → 485
    PHA03247; large tegument protein UL36; Provisional
    pfam01529
    Location:164 → 287
    DHHC; DHHC palmitoyltransferase

  2. NM_153746.2 → NP_714968.1  palmitoyltransferase ZDHHC14 isoform 2

    See identical proteins and their annotated locations for NP_714968.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
    Source sequence(s)
    AF542389, AL117344
    Consensus CDS
    CCDS47510.1
    UniProtKB/TrEMBL
    A4FVA9
    Related
    ENSP00000410713.2, ENST00000414563.6
    Conserved Domains (2) summary
    PHA03247
    Location:314 → 470
    PHA03247; large tegument protein UL36; Provisional
    pfam01529
    Location:164 → 287
    DHHC; DHHC palmitoyltransferase

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    157381190..157678157
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419366.1 → XP_047275322.1  palmitoyltransferase ZDHHC14 isoform X3

  2. XM_017011308.2 → XP_016866797.1  palmitoyltransferase ZDHHC14 isoform X1

  3. XM_017011309.2 → XP_016866798.1  palmitoyltransferase ZDHHC14 isoform X2

  4. XM_017011310.2 → XP_016866799.1  palmitoyltransferase ZDHHC14 isoform X4

  5. XM_047419368.1 → XP_047275324.1  palmitoyltransferase ZDHHC14 isoform X5

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    158623184..158923532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054356439.1 → XP_054212414.1  palmitoyltransferase ZDHHC14 isoform X3

  2. XM_054356437.1 → XP_054212412.1  palmitoyltransferase ZDHHC14 isoform X1

  3. XM_054356438.1 → XP_054212413.1  palmitoyltransferase ZDHHC14 isoform X2

  4. XM_054356440.1 → XP_054212415.1  palmitoyltransferase ZDHHC14 isoform X4

  5. XM_054356441.1 → XP_054212416.1  palmitoyltransferase ZDHHC14 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IZN3.1 GenPept UniProtKB/Swiss-Prot:Q8IZN3

Gene LinkOut

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