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ARMT1 acidic residue methyltransferase 1 [ Homo sapiens (human) ]

Gene ID: 79624, updated on 11-Apr-2024

Summary

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Official Symbol
ARMT1provided by HGNC
Official Full Name
acidic residue methyltransferase 1provided by HGNC
Primary source
HGNC:HGNC:17872
See related
Ensembl:ENSG00000146476 MIM:616332; AllianceGenome:HGNC:17872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C6orf211
Summary
Enables S-adenosylmethionine-dependent methyltransferase activity; enzyme binding activity; and protein carboxyl O-methyltransferase activity. Involved in methylation and regulation of response to DNA damage stimulus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 18.3), kidney (RPKM 17.3) and 24 other tissues See more
Orthologs
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Genomic context

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Location:
6q25.1
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (151452466..151470101)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (152653108..152670749)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (151773601..151791236)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901433 Neighboring gene heat shock protein family A (Hsp70) member 8 pseudogene 15 Neighboring gene required for meiotic nuclear division 1 homolog Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25283 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17688 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr6:151776537-151777294 Neighboring gene uncharacterized LOC124901434 Neighboring gene uncharacterized LOC124901436 Neighboring gene coiled-coil domain containing 170

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human ARMT1 structure and substrate specificity indicates that it is a DUF89 family damage-control phosphatase. Dennis TN, et al. J Struct Biol, 2020 Oct 1. PMID 32682077
  2. Armt1: a phoenix rises from the ashes. Hoelz D. Oncotarget, 2015 Oct 20. PMID 26450907, Free PMC Article
  3. Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage response. Perry JJ, et al. Cell Rep, 2015 Mar 3. PMID 25732820, Free PMC Article
  4. ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1. Dunbier AK, et al. PLoS Genet, 2011 Apr. PMID 21552322, Free PMC Article
  5. A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia. Kim DH, et al. Blood, 2011 Jun 23. PMID 21540461

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Human ARMT1 structure and substrate specificity indicates that it is a DUF89 family damage-control phosphatase.
    Title: Human ARMT1 structure and substrate specificity indicates that it is a DUF89 family damage-control phosphatase.
  2. Studies show that acidic residue methyltransferase 1 (Armt1) has a vital role in regulation of the DNA damage response likely through its ability to O-methylate glutamyl residues of the DNA repair factor proliferating cell nuclear antigen (PCNA).
    Title: Armt1: a phoenix rises from the ashes.
  3. Armt1 protein specifically targets proliferating cell nuclear antigen (PCNA) in breast cancer cells, predominately methylating glutamate side chains.
    Title: Human C6orf211 encodes Armt1, a protein carboxyl methyltransferase that targets PCNA and is linked to the DNA damage response.
  4. C6ORF211 correlates with proliferation and clinical outcome in tumors.
    Title: ESR1 is co-expressed with closely adjacent uncharacterised genes spanning a breast cancer susceptibility locus at 6q25.1.
  5. Observational study of gene-disease association. (HuGE Navigator)
    Title: Candidate gene/loci studies in cleft lip/palate and dental anomalies finds novel susceptibility genes for clefts.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ12910, DKFZp566I174

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables S-adenosylmethionine-dependent methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables enzyme binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables fructose 6-phosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
  
enables fructose-1-phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein carboxyl O-methyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-glutamate O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA damage response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
damage-control phosphatase ARMT1
Names
UPF0364 protein C6orf211
protein-glutamate O-methyltransferase
sugar phosphate phosphatase ARMT1
NP_001273491.1
NP_078849.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286562.2 → NP_001273491.1  damage-control phosphatase ARMT1 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon in the 5' region, and it thus differs in its 5' UTR and initiates translation from a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a.
    Source sequence(s)
    AK022972, AK298490, BC011348, DB443862
    Consensus CDS
    CCDS69224.1
    UniProtKB/TrEMBL
    B4DPT6, F5GZY1
    Related
    ENSP00000444121.1, ENST00000545879.5
    Conserved Domains (1) summary
    pfam01937
    Location:1 → 300
    DUF89; Protein of unknown function DUF89

  2. NM_024573.3 → NP_078849.1  damage-control phosphatase ARMT1 isoform a

    See identical proteins and their annotated locations for NP_078849.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AK022972, BC011348
    Consensus CDS
    CCDS5233.1
    UniProtKB/Swiss-Prot
    Q96FC6, Q9H993, Q9UFY5
    Related
    ENSP00000356263.3, ENST00000367294.4
    Conserved Domains (1) summary
    pfam01937
    Location:20 → 419
    DUF89; Protein of unknown function DUF89

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    151452466..151470101
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    152653108..152670749
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H993.1 GenPept UniProtKB/Swiss-Prot:Q9H993

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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