CORO7 coronin 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: CORO7provided by HGNC
Official Full Name: coronin 7provided by HGNC
Primary source: HGNC:HGNC:26161
See related: Ensembl:ENSG00000262246 MIM:611668; AllianceGenome:HGNC:26161
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CRN7; POD1; 0610011B16Rik
Summary: This gene encodes a member of the coronin protein family. However, unlike other coronin proteins, it is not an actin-binding protein but rather functions as an F-actin regulator directing anterograde Golgi to endosome transport. The encoded protein has two tandem WD-40 domain repeats and localizes to the trans-Golgi network. The protein undergoes K33-linked polyubiquitination via an E3 ligase complex. It is thought to play an essential role in maintenance of Golgi apparatus morphology. Alternative splicing results in multiple transcripts variants; some of which form read-through transcripts with a neighboring gene. [provided by RefSeq, Dec 2016]
Expression: Broad expression in bone marrow (RPKM 25.2), spleen (RPKM 18.8) and 24 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (4354542..4416596, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (4383717..4445792, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (4404543..4466597, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Obese children had significantly lower methylation levels at a CpG site located near coronin 7 (CORO7), which encodes a tryptophan-aspartic acid dipeptide (WD)-repeat containing protein most likely involved in Golgi complex morphology and function
Title: Implication of coronin 7 in body weight regulation in humans, mice and flies.
Results show that enforced targeting of Crn7 to TGN 9trans-Golgi network) bypasses the requirement of K33-ubiquitination for TGN-pool F-actin assembly and post-Golgi trafficking.
Title: K33-Linked Polyubiquitination of Coronin 7 by Cul3-KLHL20 Ubiquitin E3 Ligase Regulates Protein Trafficking.
Data show that CRN7 interacted with Cullin1 and Roc1 to form a novel SCF-like E3 complex.
Title: Coronin7 forms a novel E3 ubiquitin ligase complex to promote the degradation of the anti-proliferative protein Tob.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Sequential events of protein interaction and posttranslational modification result in the membrane targeting of Crn7.
Title: Molecular mechanism underlying the association of Coronin-7 with Golgi membranes.
Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi
Title: Crn7 interacts with AP-1 and is required for the maintenance of Golgi morphology and protein export from the Golgi.
role in the organization of intracellular membrane compartments and vesicular trafficking rather than in remodeling the cytoskeleton
Title: Coronin 7, the mammalian POD-1 homologue, localizes to the Golgi apparatus.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Cda1eg08 (e-PCR)
- UniSTS:75264

D8S2279 (e-PCR)
- UniSTS:473907

SHGC-56815 (e-PCR)
- UniSTS:66425

D1S3690 (e-PCR)
- UniSTS:474268

RH69410 (e-PCR)
- UniSTS:70815

D6S1566 (e-PCR), detects polymorphism
- UniSTS:9403

MARC_3453-3454:996679102:1 (e-PCR)
- UniSTS:269253

Readthrough CORO7-PAM16

Readthrough gene: CORO7-PAM16, Included gene: PAM16

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Golgi organization	IEA Inferred from Electronic Annotation more info
involved_in Golgi to endosome transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in actin filament polymerization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell migration	IEA Inferred from Electronic Annotation more info
involved_in establishment of cell polarity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hippo signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	HDA more info	PubMed
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: coronin-7

Names: 70 kDa WD repeat tumor rejection antigen homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_052966.1 RefSeqGene

Range

5366..67420

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001201472.2 → NP_001188401.1 coronin-7 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AC012676, AK294045, BM671637

Consensus CDS

CCDS58417.1

UniProtKB/TrEMBL

B4DKU9

Related

ENSP00000440460.2, ENST00000537233.6

Conserved Domains (4) summary

pfam08953
Location:5 → 60

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:790 → 834

WD40_4; Type of WD40 repeat

sd00039
Location:486 → 522

7WD40; WD40 repeat [structural motif]

cl02567
Location:528 → 686

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001201473.2 → NP_001188402.1 coronin-7 isoform 3

See identical proteins and their annotated locations for NP_001188402.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks two exons that result in a missing in-frame segment in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AK296807, BM671637

Consensus CDS

CCDS55982.1

UniProtKB/TrEMBL

B4DKU9

Related

ENSP00000461702.1, ENST00000574025.5

Conserved Domains (4) summary

pfam08953
Location:5 → 60

DUF1899; Domain of unknown function (DUF1899)

pfam16300
Location:723 → 767

WD40_4; Type of WD40 repeat

sd00039
Location:419 → 455

7WD40; WD40 repeat [structural motif]

cl02567
Location:461 → 619

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001351729.2 → NP_001338658.1 coronin-7 isoform 4

Status: REVIEWED

Source sequence(s)

AK094596, BM671637, DA944874

UniProtKB/TrEMBL

B3KSY4, B3KUH7

Conserved Domains (2) summary

sd00039
Location:284 → 320

7WD40; WD40 repeat [structural motif]

cl25676
Location:251 → 660

WD40_4; Type of WD40 repeat
NM_024535.5 → NP_078811.3 coronin-7 isoform 1

See identical proteins and their annotated locations for NP_078811.3

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

BC117291, BM671637, DR155527

Consensus CDS

CCDS10513.1

UniProtKB/Swiss-Prot

B4DFD6, B4DL18, I3L416, P57737, Q17RK4

UniProtKB/TrEMBL

B4DKU9

Related

ENSP00000251166.4, ENST00000251166.9

Conserved Domains (2) summary

sd00039
Location:81 → 124

7WD40; WD40 repeat [structural motif]

cl25676
Location:471 → 880

WD40_4; Type of WD40 repeat