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Mettl27 methyltransferase like 27 [ Mus musculus (house mouse) ]

Gene ID: 79565, updated on 3-Apr-2024

Summary

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Official Symbol
Mettl27provided by MGI
Official Full Name
methyltransferase like 27provided by MGI
Primary source
MGI:MGI:1933146
See related
Ensembl:ENSMUSG00000040557 AllianceGenome:MGI:1933146
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wbscr27
Summary
Predicted to enable methyltransferase activity. Orthologous to human METTL27 (methyltransferase like 27). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 16.2), genital fat pad adult (RPKM 9.5) and 26 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 74.89 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (134961158..134971491)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (134932304..134942637)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 270 Neighboring gene claudin 13 Neighboring gene STARR-seq mESC enhancer starr_14554 Neighboring gene RIKEN cDNA 9030607J07 gene Neighboring gene STARR-positive B cell enhancer ABC_E1310 Neighboring gene STARR-seq mESC enhancer starr_14556 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135417798-135418057 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135427401-135427609 Neighboring gene claudin 4 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:135442157-135442340 Neighboring gene STARR-seq mESC enhancer starr_14561 Neighboring gene Williams Beuren syndrome chromosome region 25 (human) Neighboring gene claudin 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification of an Alternative Splicing Product of the Otx2 Gene Expressed in the Neural Retina and Retinal Pigmented Epithelial Cells. Kole C, et al. PLoS One, 2016. PMID 26985665, Free PMC Article
  2. Generation and comparative analysis of approximately 3.3 Mb of mouse genomic sequence orthologous to the region of human chromosome 7q11.23 implicated in Williams syndrome. DeSilva U, et al. Genome Res, 2002 Jan. PMID 11779826, Free PMC Article
  3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
  4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
  5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

General gene information

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Markers

Homology

Clone Names

  • MGC8159

General protein information

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Preferred Names
methyltransferase-like protein 27
Names
Williams Beuren syndrome chromosome region 27
Williams-Beuren syndrome chromosome region 27 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347490.1 → NP_001334419.1  methyltransferase-like protein 27 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
    Source sequence(s)
    AC079938
    Consensus CDS
    CCDS84970.1
    UniProtKB/TrEMBL
    Q3V1G0, Q8BY07
    Related
    ENSMUSP00000106852.3, ENSMUST00000111221.9
    Conserved Domains (2) summary
    COG4976
    Location:30 → 115
    COG4976; Predicted methyltransferase, contains TPR repeat [General function prediction only]
    pfam13649
    Location:71 → 109
    Methyltransf_25; Methyltransferase domain

  2. NM_001359535.1 → NP_001346464.1  methyltransferase-like protein 27 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) represents the longest transcript and encodes the longer isoform (1). Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC079938, FO717931
    Consensus CDS
    CCDS19727.1
    UniProtKB/TrEMBL
    Q3V1G0, Q8BGM4
    Related
    ENSMUSP00000106849.2, ENSMUST00000111218.8
    Conserved Domains (2) summary
    pfam13649
    Location:71 → 162
    Methyltransf_25; Methyltransferase domain
    cl17173
    Location:29 → 109
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. NM_001359536.1 → NP_001346465.1  methyltransferase-like protein 27 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC079938, AY354926
    Consensus CDS
    CCDS19727.1
    UniProtKB/TrEMBL
    Q3V1G0, Q8BGM4
    Related
    ENSMUSP00000106850.2, ENSMUST00000111219.8
    Conserved Domains (2) summary
    pfam13649
    Location:71 → 162
    Methyltransf_25; Methyltransferase domain
    cl17173
    Location:29 → 109
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. NM_001359537.1 → NP_001346466.1  methyltransferase-like protein 27 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AC079938
    Consensus CDS
    CCDS19727.1
    UniProtKB/TrEMBL
    Q3V1G0, Q8BGM4
    Related
    ENSMUSP00000144170.2, ENSMUST00000201847.3
    Conserved Domains (2) summary
    pfam13649
    Location:71 → 162
    Methyltransf_25; Methyltransferase domain
    cl17173
    Location:29 → 109
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. NM_001359538.1 → NP_001346467.1  methyltransferase-like protein 27 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 3. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 6 both encode the same isoform (2).
    Source sequence(s)
    AC079938, AK042578
    Consensus CDS
    CCDS84970.1
    UniProtKB/TrEMBL
    Q3V1G0, Q8BY07
    Related
    ENSMUSP00000067814.6, ENSMUST00000068617.12
    Conserved Domains (2) summary
    COG4976
    Location:30 → 115
    COG4976; Predicted methyltransferase, contains TPR repeat [General function prediction only]
    pfam13649
    Location:71 → 109
    Methyltransf_25; Methyltransferase domain

  6. NM_001425731.1 → NP_001412660.1  methyltransferase-like protein 27 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC079938
    UniProtKB/TrEMBL
    Q8BY07

  7. NM_001425732.1 → NP_001412661.1  methyltransferase-like protein 27 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC079938
    UniProtKB/TrEMBL
    Q8BY07

  8. NM_001425733.1 → NP_001412662.1  methyltransferase-like protein 27 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC079938
    UniProtKB/TrEMBL
    Q8BY07

  9. NM_001425734.1 → NP_001412663.1  methyltransferase-like protein 27 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC079938
    UniProtKB/TrEMBL
    Q8BGM4

  10. NM_024479.2 → NP_077799.2  methyltransferase-like protein 27 isoform 1

    See identical proteins and their annotated locations for NP_077799.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR compared to variant 3. Variants 1, 3, 4, and 5 all encode the same isoform (1).
    Source sequence(s)
    AY354925
    Consensus CDS
    CCDS19727.1
    UniProtKB/TrEMBL
    Q3V1G0, Q8BGM4
    Related
    ENSMUSP00000039080.8, ENSMUST00000047196.14
    Conserved Domains (2) summary
    pfam13649
    Location:71 → 162
    Methyltransf_25; Methyltransferase domain
    cl17173
    Location:29 → 109
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    134961158..134971491
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006504522.4 → XP_006504585.1  methyltransferase-like protein 27 isoform X1

    See identical proteins and their annotated locations for XP_006504585.1

    UniProtKB/TrEMBL
    Q3V1G0
    Conserved Domains (2) summary
    pfam13649
    Location:71 → 161
    Methyltransf_25; Methyltransferase domain
    cl17173
    Location:31 → 103
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  2. XM_006504528.4 → XP_006504591.1  methyltransferase-like protein 27 isoform X1

    See identical proteins and their annotated locations for XP_006504591.1

    UniProtKB/TrEMBL
    Q3V1G0
    Conserved Domains (2) summary
    pfam13649
    Location:71 → 161
    Methyltransf_25; Methyltransferase domain
    cl17173
    Location:31 → 103
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  3. XM_006504527.4 → XP_006504590.1  methyltransferase-like protein 27 isoform X1

    See identical proteins and their annotated locations for XP_006504590.1

    UniProtKB/TrEMBL
    Q3V1G0
    Conserved Domains (2) summary
    pfam13649
    Location:71 → 161
    Methyltransf_25; Methyltransferase domain
    cl17173
    Location:31 → 103
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  4. XM_006504529.4 → XP_006504592.1  methyltransferase-like protein 27 isoform X1

    See identical proteins and their annotated locations for XP_006504592.1

    UniProtKB/TrEMBL
    Q3V1G0
    Conserved Domains (2) summary
    pfam13649
    Location:71 → 161
    Methyltransf_25; Methyltransferase domain
    cl17173
    Location:31 → 103
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

  5. XM_006504524.5 → XP_006504587.1  methyltransferase-like protein 27 isoform X1

    See identical proteins and their annotated locations for XP_006504587.1

    UniProtKB/TrEMBL
    Q3V1G0
    Conserved Domains (2) summary
    pfam13649
    Location:71 → 161
    Methyltransf_25; Methyltransferase domain
    cl17173
    Location:31 → 103
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
Nucleotide Protein Strain
Heading Accession and Version

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