U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

OR13A1 olfactory receptor family 13 subfamily A member 1 [ Homo sapiens (human) ]

Gene ID: 79290, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
OR13A1provided by HGNC
Official Full Name
olfactory receptor family 13 subfamily A member 1provided by HGNC
Primary source
HGNC:HGNC:14772
See related
Ensembl:ENSG00000256574 AllianceGenome:HGNC:14772
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
10q11.21
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (45302297..45315608, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (46183344..46196657, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (45798098..45811056, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cubilin pseudogene 2 Neighboring gene olfactory receptor family 6 subfamily D member 1 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr10:45839254-45839455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45869432-45870042 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45870043-45870651 Neighboring gene arachidonate 5-lipoxygenase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45914387-45915080 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45915081-45915772 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45915801-45916302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45921315-45921815 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45923135-45923798 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45928754-45929292 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:45928214-45928753 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:45933181-45934380 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:45937030-45937261 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45937618-45938388 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45938389-45939157 Neighboring gene uncharacterized LOC102724323 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:45958734-45959933 Neighboring gene uncharacterized LOC105378286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45970297-45970798 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45970799-45971298 Neighboring gene membrane associated ring-CH-type finger 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:45998823-45999323

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The DNA sequence and comparative analysis of human chromosome 10. Deloukas P, et al. Nature, 2004 May 27. PMID 15164054
  2. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article
  3. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ16797

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables odorant binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
olfactory receptor 13A1
Names
olfactory receptor OR10-3
seven transmembrane helix receptor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004297.3 → NP_001004297.2  olfactory receptor 13A1

    See identical proteins and their annotated locations for NP_001004297.2

    Status: VALIDATED

    Source sequence(s)
    AK131555, AL512324
    Consensus CDS
    CCDS31188.1
    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8, A0A126GW17
    Related
    ENSP00000451950.1, ENST00000553795.6
    Conserved Domains (1) summary
    cd15232
    Location:43 → 312
    7tmA_OR13-like; olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    45302297..45315608 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047425731.1 → XP_047281687.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8

  2. XM_047425730.1 → XP_047281686.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8
    Related
    ENSP00000363522.2, ENST00000374401.3

  3. XM_047425729.1 → XP_047281685.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8

  4. XM_017016632.3 → XP_016872121.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8, A0A126GW17
    Conserved Domains (1) summary
    cd15232
    Location:43 → 312
    7tmA_OR13-like; olfactory receptor family 13 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NW_003315935.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    127062..140376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054329563.1 → XP_054185538.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8

  2. XM_054329561.1 → XP_054185536.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8

  3. XM_054329562.1 → XP_054185537.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    46183344..46196657 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366717.1 → XP_054222692.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8

  2. XM_054366716.1 → XP_054222691.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8

  3. XM_054366713.1 → XP_054222688.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8

  4. XM_054366714.1 → XP_054222689.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8

  5. XM_054366715.1 → XP_054222690.1  olfactory receptor 13A1 isoform X1

    UniProtKB/Swiss-Prot
    Q2M3M4, Q5VV57, Q6IFH5, Q6ZMN6, Q8NGR1
    UniProtKB/TrEMBL
    A0A126GVD8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NGR1.2 GenPept UniProtKB/Swiss-Prot:Q8NGR1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous