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DCAF10 DDB1 and CUL4 associated factor 10 [ Homo sapiens (human) ]

Gene ID: 79269, updated on 5-Mar-2024

Summary

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Official Symbol
DCAF10provided by HGNC
Official Full Name
DDB1 and CUL4 associated factor 10provided by HGNC
Primary source
HGNC:HGNC:23686
See related
Ensembl:ENSG00000122741 MIM:620295; AllianceGenome:HGNC:23686
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WDR32
Summary
Predicted to be involved in protein ubiquitination. Part of Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis (RPKM 8.3), thyroid (RPKM 6.2) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
9p13.2
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (37800554..37867664)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (37824285..37891574)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (37800551..37867661)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ReSE screen-validated silencer GRCh37_chr9:37753712-37753946 Neighboring gene tRNA methyltransferase 10B Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28402 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:37784801-37785316 Neighboring gene uncharacterized LOC105376037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:37800323-37800924 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19913 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28404 Neighboring gene exosome component 3 Neighboring gene mitochondrial ribosomal protein S10 pseudogene 5 Neighboring gene solute carrier family 25 member 51 Neighboring gene phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19914 Neighboring gene thioredoxin related transmembrane protein 2 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:37923197-37923808 Neighboring gene RNA, U7 small nuclear 124 pseudogene Neighboring gene SH2 domain containing adaptor protein B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. OTUD1 Activates Caspase-Independent and Caspase-Dependent Apoptosis by Promoting AIF Nuclear Translocation and MCL1 Degradation. Luo Q, et al. Adv Sci (Weinh), 2021 Apr. PMID 33898171, Free PMC Article
  2. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. Lignitto L, et al. Cell, 2019 Jul 11. PMID 31257023, Free PMC Article
  3. CRL4(AMBRA1) is a master regulator of D-type cyclins. Simoneschi D, et al. Nature, 2021 Apr. PMID 33854235, Free PMC Article
  4. Molecular architecture and assembly of the DDB1-CUL4A ubiquitin ligase machinery. Angers S, et al. Nature, 2006 Oct 5. PMID 16964240
  5. PIKES Analysis Reveals Response to Degraders and Key Regulatory Mechanisms of the CRL4 Network. Reichermeier KM, et al. Mol Cell, 2020 Mar 5. PMID 31973889

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress.
    Title: Adenovirus E1A binding to DCAF10 targets proteasomal degradation of RUVBL1/2 AAA+ ATPases required for quaternary assembly of multiprotein machines, innate immunity, and responses to metabolic stress.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ23201, MGC10765, MGC131781

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
DDB1- and CUL4-associated factor 10
Names
WD repeat domain 32
WD repeat-containing protein 32

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286810.2 → NP_001273739.1  DDB1- and CUL4-associated factor 10 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate 5' terminal exon and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The encoded isoform (b) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AK309712, AL138752, BC108686, CB045943
    Consensus CDS
    CCDS75835.1
    UniProtKB/TrEMBL
    A0A0A0MQT4
    Related
    ENSP00000242323.8, ENST00000242323.8
    Conserved Domains (2) summary
    sd00039
    Location:2 → 34
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:9 → 146
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. NM_024345.5 → NP_077321.3  DDB1- and CUL4-associated factor 10 isoform a

    See identical proteins and their annotated locations for NP_077321.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL138752, BC108686, CB045943, HY015327
    Consensus CDS
    CCDS6613.2
    UniProtKB/Swiss-Prot
    A4VCJ5, Q32NE2, Q5QP82, Q8N2Q5, Q96ET5, Q9BTQ5, Q9H5P6
    Related
    ENSP00000366953.3, ENST00000377724.8
    Conserved Domains (4) summary
    smart00320
    Location:517 → 555
    WD40; WD40 repeats
    COG2319
    Location:171 → 334
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:172 → 207
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:164 → 319
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    37800554..37867664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423865.1 → XP_047279821.1  DDB1- and CUL4-associated factor 10 isoform X5

  2. XM_047423866.1 → XP_047279822.1  DDB1- and CUL4-associated factor 10 isoform X6

  3. XM_005251577.5 → XP_005251634.1  DDB1- and CUL4-associated factor 10 isoform X1

    UniProtKB/Swiss-Prot
    Q5QP82
    Conserved Domains (3) summary
    COG2319
    Location:169 → 518
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:172 → 207
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:169 → 519
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  4. XM_005251578.5 → XP_005251635.1  DDB1- and CUL4-associated factor 10 isoform X2

    Conserved Domains (3) summary
    smart00320
    Location:451 → 489
    WD40; WD40 repeats
    COG2319
    Location:169 → 489
    WD40; WD40 repeat [General function prediction only]
    cl02567
    Location:164 → 223
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  5. XM_017015128.2 → XP_016870617.1  DDB1- and CUL4-associated factor 10 isoform X3

  6. XM_047423864.1 → XP_047279820.1  DDB1- and CUL4-associated factor 10 isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    37824285..37891574
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363790.1 → XP_054219765.1  DDB1- and CUL4-associated factor 10 isoform X5

  2. XM_054363791.1 → XP_054219766.1  DDB1- and CUL4-associated factor 10 isoform X6

  3. XM_054363786.1 → XP_054219761.1  DDB1- and CUL4-associated factor 10 isoform X1

  4. XM_054363787.1 → XP_054219762.1  DDB1- and CUL4-associated factor 10 isoform X2

  5. XM_054363788.1 → XP_054219763.1  DDB1- and CUL4-associated factor 10 isoform X3

  6. XM_054363789.1 → XP_054219764.1  DDB1- and CUL4-associated factor 10 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5QP82.1 GenPept UniProtKB/Swiss-Prot:Q5QP82

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